In vitro and In vivo Antibacterial and Anti-inflammatory  Properties of Linalool

Varia, R.D.; Patel, Jatin H.; Modi, Falguni D.; Vihol, Priti D.; Bhavsar, Shailesh K.

doi:10.20546/ijcmas.2020.909.187

Cited by 12 publications

(4 citation statements)

References 10 publications

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“…Moreover, minor and peripheral compounds such as trans-β-ocimene, linalool, β–myrcene, geraniol, germacrene D, and geranyl acetate could be effective in this activity. The inhibitory effect of myrcene [ 74 ], linalool [ 75 ]. and EOs containing sabinene and trans-β-ocimene [ 76 ] against some Salmonella variants has been recorded.…”

Section: Resultsmentioning

confidence: 99%

A GC-MC analysis of chemical compounds and identification of the antibacterial characteristics of the essential oil of two species exclusive to Iranian habitats: New chemotypes

Ghavam

2022

PLoS ONE

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Background The diversity found in the chemical compounds of a single species in different regions results in different biologic characteristics which can be considered as a strong source for identifying new chemotypes. Hymenocrater incanus Bunge and Dracocephalum kotschyi Boiss. are exclusive species of the Lamiaceae family which grow in the western and central habitats of Iran. This study was designed and carried out to determine the yield, identify the chemical compounds, and evaluate the antimicrobial characteristics of the essential oil (EO) of these two species in Iran for the first time. Methods The flowering twigs of the species D. kotschyi and H. incanus were collected from the villages of Totmach and Kamu in Isfahan province respectively, in May 2019. The EO of these plants was extracted and separated using the water distillation method, utilizing the Clevenger device. The EO compounds were analyzed using a gas chromatograph coupled with a mass spectrometer (GC-MS). The evaluation of antimicrobial characteristics was carried out by determining the growth inhibition zone implementing the Agar method, the minimum inhibition concentration (MIC), and the minimum bactericidal/fungicidal concentration (MFC/MBC) utilizing liquid dilution culture. Results The results indicated that the highest yield belonged to the EO of D. kotschyi at %2.6 (w/w). In this EO there were citral (%25.44), neral (%20.87), α-pinene (%14.48), trans-geranic acid methyl ester (%9.74), and D-limonene (%6.87). Moreover, H. incanus had the dominant compounds (-)-Spathulenol (%12.61), caryophyllene (%10.00), linolenic acid (%8.54), 1,8-cineole (%5.95), palmitic acid (%5.35), and α-cadinol (%5.17). The largest diameter of growth inhibition zone belonged to the H. incanus EO against the Gram-positive bacteria S. pyogenes (~17.67mm). The strongest inhibition activities in the form of growth inhibition diameter exhibited by the D. kotschyi EO were against the Gram-negative bacteria S. paratyphi-A serotype (~ 12 mm), K. pneumoniae, and Sh. dysenteriae (~ 11 mm) which was significant compared to the Gram-positive rifampin (~ 8 mm). Conclusions It can be seen that these species are new chemotypes with special and novel chemical compounds which can potentially be used to manufacture natural antibiotics against some bacterial strains.

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Section: Resultsmentioning

confidence: 99%

A GC-MC analysis of chemical compounds and identification of the antibacterial characteristics of the essential oil of two species exclusive to Iranian habitats: New chemotypes

Ghavam

2022

PLoS ONE

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“…In lipopolysaccharide challenged RAW264.7 macrophage cells, linalool was confirmed anti-inflammatory effect by quantifying its capacity to suppress the enzyme cycloxygenase & PGE 2 levels, as well as assessing nitric oxide generation in comparison to the lipopolysaccharide control group, it was found that in all concentration of linalool (10, 50, & 100 µM) considerably lowered the generation of nitric oxide and PGE2 [13].…”

Section: Anti-inflammatorymentioning

confidence: 97%

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Singh,

Mishra

2024

Drug Res (Stuttg)

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This comprehensive review endeavors to illuminate the nuanced facets of linalool, a prominent monoterpene found abundantly in essential oils, constituting a massive portion of their composition. The biomedical relevance of linalool is a key focus, highlighting its therapeutic attributes observed through anti-nociceptive effects, anxiolytic properties, and behavioral modulation in individuals affected by dementia. These findings underscore the compound's potential application in biomedical applications. This review further explores contemporary formulations, delineating the adaptability of linalool in nano-emulsions, microemulsions, bio-capsules, and various topical formulations, including topical gels and lotions. This review covers published and granted patents between 2018–2024 and sheds light on the evolving landscape of linalool applications, revealing advancements in dermatological, anti-inflammatory, and antimicrobial domains.

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“…Another often-raised biological action of lavender oils is their anti-inflammatory effect. Linalool, the main component of lavender oil, has been reported to have anti-inflammatory effects [ 7 , 52 , 76 , 77 ]. Huo and coworkers tested the action of this terpene on lipopolysaccharide(LPS)-induced production of inflammatory mediators such as tumor necrosis factor α (TNF-α) a and interleukin 6 (IL-6) [ 78 ].…”

Section: Biological Activities Of Lavandinmentioning

confidence: 99%

Lavandula x intermedia—A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin

et al. 2023

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This review article is the second in a series aimed at providing an in-depth overview of Lavandula x intermedia (lavandin). In part I, the biology and chemistry of lavandin were addressed. In part II, the focus is on the functional properties of lavandin and its applications in industry and daily life. While reviewing the biological properties, only original research articles employing lavandin were considered. Lavandin essential oil has been found to have antioxidant and biocidal activity (antimicrobial, nematicidal, antiprotozoal, insecticidal, and allelopathic), as well as other potential therapeutic effects such as anxiolytic, neuroprotective, improving sleep quality, antithrombotic, anti-inflammatory, and analgesic. Other lavandin preparations have been investigated to a much lesser extent. The research is either limited or inconsistent across all studies, and further evidence is needed to support these properties. Unlike its parent species—Lavandula angustifolia (LA)—lavandin essential oil is not officially recognized as a medicinal raw material in European Pharmacopeia. However, whenever compared to LA in shared studies, it has shown similar effects (or even more pronounced in the case of biocidal activities). This suggests that lavandin has similar potential for use in medicine.

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In vitro and In vivo Antibacterial and Anti-inflammatory Properties of Linalool

Cited by 12 publications

References 10 publications

A GC-MC analysis of chemical compounds and identification of the antibacterial characteristics of the essential oil of two species exclusive to Iranian habitats: New chemotypes

A GC-MC analysis of chemical compounds and identification of the antibacterial characteristics of the essential oil of two species exclusive to Iranian habitats: New chemotypes

Linalool: Therapeutic Indication And Their Multifaceted Biomedical Applications

Lavandula x intermedia—A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin

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