In vitro and in vivo evaluations of Mg-Zn-Gd alloy membrane on guided bone regeneration for rabbit calvarial defect

Si, Jiawen; Shen, Huanfeng; Miao, Hongwei; Tian, Yuan; Huang, Hua; Shi, Jun; Yuan, Guangyin; Shen, Guofang

doi:10.1016/j.jma.2020.09.013

Cited by 32 publications

(16 citation statements)

References 39 publications

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“…30 One study by Si et al recently demonstrated the positive effects of gadolinium (Gd) and zinc (Zn) in Mg−Zn−Gd alloy membranes on guided bone regeneration for rabbit calvarial defects. 89 Meanwhile, none to low cytotoxic effect and improvement of corrosion resistance for Mg alloys modified with lower concentrations of gallium (Ga) are available in the literature, although Ga is known as one of the bone resorption inhibitors. 41,90 3.2.2.…”

Section: Resultsmentioning

confidence: 99%

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Tamay

Gokyer

Schmidt

et al. 2021

ACS Appl. Mater. Interfaces

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In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium−calcium (MgCa1) alloys were modified with calcium phosphate (CaP) or CaP doped with zinc (Zn) or gallium (Ga) via microarc oxidation. The effects of surface modifications on physical, chemical, and mechanical properties and corrosion resistance of the alloys were studied using surface profilometry, goniometry, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), nanoindentation, and electrochemical impedance spectroscopy (EIS). The coating thickness was about 5−8 μm, with grain sizes of 43.1 nm for CaP coating and 28.2 and 58.1 nm for Zn-and Ga-doped coatings, respectively. According to EIS measurements, the capacitive response (Y c ) decreased from 11.29 to 8.72 and 0.15 Ω −1 cm −2 s n upon doping with Zn and Ga, respectively. The E corr value, which was −1933 mV for CaP-coated samples, was found significantly electropositive at −275 mV for Ga-doped ones. All samples were cytocompatible according to indirect tests. In vitro culture with Saos-2 cells led to changes in the surface compositions of the alloys. The numbers of cells attached to the Zn-doped (2.6 × 10 4 cells/cm 2 ) and Ga-doped (6.3 × 10 4 cells/cm 2 ) coatings were higher than that on the surface of the undoped coating (1.0 × 10 3 cells/cm 2 ). Decreased corrosivity and enhanced cell affinity of the modified MgCa alloys (CaP coated and Zn and Ga doped, with Ga-doped ones having the greatest positive effect) make them novel and promising candidates as biodegradable metallic implant materials for the treatment of bone damages and other orthopedic applications.

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Section: Resultsmentioning

confidence: 99%

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Tamay

Gokyer

Schmidt

et al. 2021

ACS Appl. Mater. Interfaces

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“…In addition, magnesium alloy does not interfere with CT and MRI imaging examination after surgery ( Farraro et al, 2014 ), which facilitates the effect after implantation. Si et al (2021) have studied a Mg-2.0Zn-1.0Gd alloy (wt%, MZG) membrane for biomedical use. The alloy material has a favorable plastic deformation ability.…”

Section: Specific Types Of Barrier Membranesmentioning

confidence: 99%

Advances in Barrier Membranes for Guided Bone Regeneration Techniques

Yang

Shi

et al. 2022

Front. Bioeng. Biotechnol.

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Guided bone regeneration (GBR) is a widely used technique for alveolar bone augmentation. Among all the principal elements, barrier membrane is recognized as the key to the success of GBR. Ideal barrier membrane should have satisfactory biological and mechanical properties. According to their composition, barrier membranes can be divided into polymer membranes and non-polymer membranes. Polymer barrier membranes have become a research hotspot not only because they can control the physical and chemical characteristics of the membranes by regulating the synthesis conditions but also because their prices are relatively low. Still now the bone augment effect of barrier membrane used in clinical practice is more dependent on the body’s own growth potential and the osteogenic effect is difficult to predict. Therefore, scholars have carried out many researches to explore new barrier membranes in order to improve the success rate of bone enhancement. The aim of this study is to collect and compare recent studies on optimizing barrier membranes. The characteristics and research progress of different types of barrier membranes were also discussed in detail.

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“…However, there is a distinction between the skeleton and the oral microenvironment, and research on the BM-based GBR membrane is still in its early stages. Table 3 summarizes the current research status of BM-based GBR membranes based on previous studies [49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67]. Following that, the feasibility of biodegradable alloys as GBR membranes will be discussed in the following sections.…”

Section: The Feasibility Of Biodegradable Alloys As Gbr Membranesmentioning

confidence: 99%

Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges

et al. 2022

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Guided bone regeneration (GBR) is a therapeutic procedure used to enhance alveolar bone volume before dental implants. Commercial non-absorbable membranes (i.e., titanium membranes) typically require a second surgery to remove, whereas absorbable membranes (i.e., collagen membranes) will fail when put over extensive bone lesions due to their low mechanical strength. The GBR membrane that has been sought is still being developed. Biodegradable metals (BMs), particularly Mg and Zn, have recently been postulated as promising barrier membrane candidates. Herein, the goal of this research is to evaluate the mechanical and biological feasibility of using BMs as GBR membranes. It shows that BMs have a wide range of potential applications as GBR membranes, owing to their benign biocompatibility, sufficient mechanical support, tunable degradation rate, good osteogenic capabilities, broad-spectrum antibacterial behavior, and improved wound healing ability. The rapid degradation rate, hydrogen evolution impact, and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes, which can be improved by surface modifications, heat treatment, alloying, etc. Due to its acceptable degradation rate and lack of gas production, Zn appears to be a better candidate for usage as a GBR membrane. In general, advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clinical trials.

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In vitro and in vivo evaluations of Mg-Zn-Gd alloy membrane on guided bone regeneration for rabbit calvarial defect

Cited by 32 publications

References 39 publications

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Corrosion Resistance and Cytocompatibility of Magnesium–Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Advances in Barrier Membranes for Guided Bone Regeneration Techniques

Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges

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