In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model

Han, Pei; Peng, Chong; Zhang, Shaoxiang; Zhao, Changli; Ni, Jiahua; Zhang, Yuanzhuang; Zhong, Wanrun; Hou, Peng; Zhang, Xiaonong; Zheng, Yufeng; Chai, Yimin

doi:10.1016/j.biomaterials.2015.06.031

Cited by 212 publications

(130 citation statements)

References 45 publications

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“…In addition, every implantation is associated with surgical trauma, which itself has an effect on resorbable implants. In vivo studies involving osteotomy were performed previously in rats, rabbits, and dogs . During the process of fracture repair, there is increased blood flow and vascularity, not only increasing the corrosion rate of magnesium implants but also decreasing gas accumulation due to faster removal .…”

Section: Analysis Of the Corrosion Ratementioning

confidence: 99%

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Willbold

Weizbauer

Loos³

et al. 2016

J Biomedical Materials Res

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The first degradable implant made of a magnesium alloy, a compression screw, was launched to the clinical market in March 2013. Many different complex considerations are required for the marketing authorization of degradable implant materials. This review gives an overview of existing and proposed standards for implant testing for marketing approval. Furthermore, different common in vitro and in vivo testing methods are discussed. In some cases, animal tests are inevitable to investigate the biological safety of a novel medical material. The choice of an appropriate animal model is as important as subsequent histological examination. Furthermore, this review focuses on the results of various mechanical tests to investigate the stability of implants for temporary use. All the above aspects are examined in the context of development and testing of magnesium-based biomaterials and their progress them from bench to bedside. A brief history of the first market launch of a magnesium-based degradable implant is given. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 329-347, 2017.

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Section: Analysis Of the Corrosion Ratementioning

confidence: 99%

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Willbold

Weizbauer

Loos³

et al. 2016

J Biomedical Materials Res

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“…13 In the past few decades, some bioactive materials containing magnesium (Mg) element have been reported, such as Mg and Mg alloys, Mg-based bioactive glasses/ bioceramics/cements and coatings. 14,15 The magnesium element has been reported to play important roles in bone remodeling and skeletal tissue development of human beings. 16 Furthermore, Mg element may enhance bone tissue mineral density and influence bone fragility, and lack of Mg element will affect all stages of skeletal metabolism, causing slow growth of bone tissue and osteoporosis.…”

Section: Wu Et Almentioning

confidence: 99%

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

Pan

et al. 2017

IJN

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Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting–particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.

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“…And Mg is similar to bony cortex in physical property . Besides, it has been reported that the Mg 2+ ion, released by Mg alloy, could efficiently irritate osteoblasts growing and bone regeneration . Still, it has some deficiencies, such as its rapid degradation rate and insufficient mechanical property .…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel biodegradable Mg‐Ag‐Y alloys for use as resorbable bone fixation implant

Dai

Luo

et al. 2018

J Biomedical Materials Res

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Magnesium (Mg) alloy is gaining more interest because of its degradability and osteogenic potential. Still, it has some deficiencies, such as its rapid degradation rate, insufficient mechanical property. This research aimed to design a novel biodegradable Mg-argentum (Ag)-yttrium (Y) alloy, and Y was added to improve degradable and mechanical property. Mg-Ag-Y alloys were characterized for mechanical features, practicabilities in vitro and in vivo. The mechanical features results shown that this novel component was similar to native bone tissue in elastic moduli, tensile, and compressive stress. Then mesenchymal stem cells (MSCs) were seeded in alloys to assess cell toxicity in vitro. The results showed that its aqueous extract was suitable for MSCs adhesion and proliferation. Then the alloy was evaluated for biomedical applications in nonfractured distal femora of Sprague Dawley rats for 6 weeks, compared with those of pure-Mg and stainless steel groups. All rats survived, and hematological and histological evaluation showed no abnormal physiology 6 weeks postimplantation, and measurements of serum Mg concentration were within normal levels. X-ray scanning, microcomputed tomography, and histological examinations were performed to evaluate the degradability and osteogenic potential. The results indicated that the degradation rate of alloy was 0.91 mm per year, (range 0.77-1.22 mm), and pure-Mg 1.80 mm per year (1.43-2.26 mm). The new bone quantity was 3.18 mm (1.46-4.44 mm ) in Mg-Ag-Y alloys group, 1.39 mm (0.54-2.32 mm ) in pure-Mg group, and none in stainless steel group. These promising results suggest potential clinical application of Mg-Ag-Y alloys for use as resorbable bone fixation implant. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2059-2069, 2018.

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In vitro and in vivo studies on the degradation of high-purity Mg (99.99wt.%) screw with femoral intracondylar fractured rabbit model

Cited by 212 publications

References 45 publications

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval‐related considerations

Nanoporosity improved water absorption, in vitro degradability, mineralization, osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

In vitro and in vivo evaluation of novel biodegradable Mg‐Ag‐Y alloys for use as resorbable bone fixation implant

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