In vitro and in vivo toxicological evaluation of transition metal-doped titanium dioxide nanoparticles: Nickel and platinum

Jin, Su-Eon; Kim, Eunju; Kim, Hyunmin; Kim, Hyunzu; Hwang, Woochul; Hong, Seok Won

doi:10.1016/j.msec.2020.110843

Cited by 8 publications

(4 citation statements)

References 39 publications

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“… 54 A recent study has reported the cytotoxicity of Ni (1%) and Pt (0.2%) doped TiO 2 in ARP-19 cells and dermal cells of balb/c mice where the ARP-9 cells have been found more susceptible to Pt doped TiO 2 and less susceptible to Ni doped TiO 2 . 55 Hence, to establish the toxicological effects of TiO 2 and doped TiO 2 nanoparticles further concentration based cytotoxicity studies are required.…”

Section: Resultsmentioning

confidence: 99%

Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

et al. 2022

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“…However, heavy metals such as Fe and Ni could cause the color to change to red and result in the complex chemical reduction state of Ti which results in troublesome issues such as photodegradation and skin irritation [28]. For N-doping, nitrogen could lower the crystallinity of TiO 2 and requires a high temperature (over 400 • C) and vacuum process.…”

Section: Of 13mentioning

confidence: 99%

The Encapsulation of Natural Organic Dyes on TiO2 for Photochromism Control

Lee

Shim

Lee

et al. 2023

IJMS

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Titanium dioxide (TiO2) plays a pivotal role in photocatalytic reactions and holds great promise for the cosmetic and paint industries due to its white color and high refractive index. However, the original color of TiO2 changes gradually to blue or yellow with UV irradiation, which affects its color realization. We encapsulated TiO2 with several natural organic dye compounds, including purpurin, curcumin, and safflower, to control its photochromism and realize a range of different colors. The chemical reaction between TiO2 and dyes based on their functional group was investigated, and the light absorption was tested via FTIR and UV–Vis spectroscopy. The changes in morphology and size distribution additionally supported their successful encapsulation. The discoloration after UV irradiation was evaluated by measuring the color difference (ΔE) of control TiO2 and dye encapsulated TiO2. The unique structure utilized natural dyes to preserve photochromism based on the physical barrier and automatically controlled the electronic transition of core TiO2. In particular, the color difference values of purpurin and curcumin were 4.05 and 3.76, which is lower than the 5.36 of the control TiO2. Dye encapsulated TiO2 was manipulated into lipstick to verify its color realization and retention.

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“…For example, the human eye might incidentally come in contact with TiO 2 -NPs; however, information regarding ocular hazards is limited. In vitro exposure of TiO 2 -NPs (> 5 μg/mL) has been reported to lower cell viability of retinal pigment epithelial (RPE) cells and human lens epithelial cells [8][9][10]. In combination with UV treatment, the TiO 2 -NPs were found to be capable of generating reactive oxygen species (ROS), resulting in apparent phototoxic damage [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…In vitro exposure of TiO 2 -NPs (> 5 μg/mL) has been reported to lower cell viability of retinal pigment epithelial (RPE) cells and human lens epithelial cells [8][9][10]. In combination with UV treatment, the TiO 2 -NPs were found to be capable of generating reactive oxygen species (ROS), resulting in apparent phototoxic damage [8][9][10]. Mice which received repetitive topical administration of TiO 2 -NP (400-1000 ng/eye) displayed goblet cell exhaustion, decreased tear mucin secretion, corneal haze, and inflammation on the ocular surface [11,12].…”

Section: Introductionmentioning

confidence: 99%

Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

et al. 2021

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Background Depending on their distinct properties, titanium dioxide nanoparticles (TiO2-NPs) are manufactured extensively and widely present in our daily necessities, with growing environmental release and public concerns. In sunscreen formulations, supplementation of TiO2-NPs may reach up to 25% (w/w). Ocular contact with TiO2-NPs may occur accidentally in certain cases, allowing undesirable risks to human vision. This study aimed to understand the barrier integrity of retinal endothelial cells in response to TiO2-NP exposure. bEnd.3 cells and human retinal endothelial cells (HRECs) were exposed to TiO2-NP, followed by examination of their tight junction components and functions. Results TiO2-NP treatment apparently induced a broken structure of the junctional plaques, conferring decreased transendothelial electrical resistance, a permeable paracellular cleft, and improved cell migration in vitro. This might involve rapid activation of metalloproteinase, a disintegrin and metalloproteinase 17 (ADAM17), and ADAM17-mediated claudin-5 degradation. For the in vivo study, C57BL/6 mice were administered a single dose of TiO2-NP intravitreally and then subjected to a complete ophthalmology examination. Fluorescein leakage and reduced blood flow at the optical disc indicated a damaged inner blood-retinal barrier induced by TiO2-NPs. Inappreciable change in the thickness of retinal sublayers and alleviated electroretinography amplitude were observed in the TiO2-NP-treated eyes. Conclusions Overall, our data demonstrate that TiO2-NP can damage endothelial cell function, thereby affecting retinal electrophysiology.

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In vitro and in vivo toxicological evaluation of transition metal-doped titanium dioxide nanoparticles: Nickel and platinum

Cited by 8 publications

References 39 publications

Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

The Encapsulation of Natural Organic Dyes on TiO2 for Photochromism Control

Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

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In vitro and in vivo toxicological evaluation of transition metal-doped titanium dioxide nanoparticles: Nickel and platinum

Cited by 8 publications

References 39 publications

Assessing the potential biological activities of TiO2 and Cu, Ni and Cr doped TiO2 nanoparticles

Assessing the potential biological activities of TiO2 and Cu, Ni and Cr doped TiO2 nanoparticles

The Encapsulation of Natural Organic Dyes on TiO2 for Photochromism Control

Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation

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Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles

Assessing the potential biological activities of TiO₂ and Cu, Ni and Cr doped TiO₂ nanoparticles