In vitro and in vivo biocompatibility of an Ag-bearing Zr-based bulk metallic glass for potential medical use

Sun, Yanhui; Huang, Yongjiang; Fan, Hongbo; Wang, Yaming; Ning, Zhiliang; Liu, Fangyu; Feng, Dongfei; Jin, Xiaoxia; Shen, Jun; Sun, Jianfei; Chen, John J. J.

doi:10.1016/j.jnoncrysol.2015.03.039

Cited by 41 publications

(26 citation statements)

References 68 publications

(87 reference statements)

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“…Unfortunately, this material developed unsatisfied mechanical properties, especially when applied in load-bearing areas [28]. In the 1960s, metallic glasses (MGs) were discovered and revealed to possess sufficient strength and superior corrosion resistance when compared to Ti alloys [29]. However, the drawback of MGs is their limited specimen size (usually in micron) which retards their application in research and biomedical field [30].…”

Section: Introductionmentioning

confidence: 99%

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

Aliyu

Rani

Ginta

et al. 2017

Advances in Materials Science and Engineering

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Surface treatment remained a key solution to numerous problems of synthetic hard tissues. The basic methods of implant surface modification include various physical and chemical deposition techniques. However, most of these techniques have several drawbacks such as excessive cost and surface cracks and require very high sintering temperature. Additive mixed-electric discharge machining (AM-EDM) is an emerging technology which simultaneously acts as a machining and surface modification technique. Aside from the mere molds, dies, and tool fabrication, AM-EDM is materializing to finishing of automobiles and aerospace, nuclear, and biomedical components, through the concept of material migrations. The mechanism of material transfer by AM-EDM resembles electrophoretic deposition, whereby the additives in the AM-EDM dielectric fluids are melted and migrate to the machined surface, forming a mirror-like finishing characterized by extremely hard, nanostructured, and nanoporous layers. These layers promote the bone in-growth and strengthen the cell adhesion. Implant shaping and surface treatment through AM-EDM are becoming a key research focus in recent years. This paper reports and summarizes the current advancement of AM-EDM as a potential tool for orthopedic and dental implant fabrication. Towards the end of this paper, the current challenges and future research trends are highlighted.

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Section: Introductionmentioning

confidence: 99%

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

Aliyu

Rani

Ginta

et al. 2017

Advances in Materials Science and Engineering

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“…[ 69 ] Further exploration of the composition space revealed Ca-rich alloys with signifi cantly increased casting diameters, and improved thermoplastic processing properties, excellent cell proliferation, and increased bone hyperplasia. [ 72,75,76 ] While the Young's modulus of the ternary systems is almost identical to that of dense cortical bone (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), the strengths are not as impressive as the Mg-rich systems, exhibiting failure in compression at around 400 MPa. Despite very limited H 2 evolution, the corrosion of the ternary alloys is very rapid, with some of the Ca-rich alloy pins dissolving completely within just 3 h. [ 75 ] Recently however, it has been demonstrated that additional alloying elements such a Yb and Sr can signifi cantly reduce the corrosion rate of the Ca-rich systems (Figure 4 ), bringing it signifi cantly below crystalline Mg-alloys, and suggesting a viable alternative to the smallerdiameter Mg-rich systems.…”

Section: Glassy Magnesium Alloysmentioning

confidence: 96%

“…In vivo implanted BMGs showed excellent host compatibility, with no gas formation nor immune response, and show similar osseointegration as Ti6Al4V. [ 25 ] The Ag-bearing Zr alloys exhibited [ 24 ] fatigue strength in excess of 400 MPa (10 7 cycles) and high fracture toughness, as well as some compressive plasticity up to 0.2%. With a strength of ca.…”

Section: Zr Systemsmentioning

confidence: 98%

“…The Ag-bearing BMGs performed signifi cantly better than Ti6Al4V in Hanks solution [ 25 ] and phosphate-buffered saline (PBS) [ 24 ] due to Al 2 O 3 passivation (which appears to be increased by Ag content), and showed marginally improved cell viabilities with L929 [ 25 ] cells, and marginally worse with MG63 [ 24 ] cells over Ti6V4Al, falling into the same cytotoxicity Grade 0-1 (along with all current biomedical alloys). Ag-bearing BMGs also show antibiotic effects, [ 26 ] and could lead to a reduction in surgical revisions due to infection.…”

Section: Zr Systemsmentioning

confidence: 99%

“…Liu et al [ 24 ] and Sun et al [ 25 ] performed in vitro corrosion and cytotoxicity testing on ZrCuAlAg alloy systems, all of which exhibit extremely good GFA (up to 20 mm d crit ). The Ag-bearing BMGs performed signifi cantly better than Ti6Al4V in Hanks solution [ 25 ] and phosphate-buffered saline (PBS) [ 24 ] due to Al 2 O 3 passivation (which appears to be increased by Ag content), and showed marginally improved cell viabilities with L929 [ 25 ] cells, and marginally worse with MG63 [ 24 ] cells over Ti6V4Al, falling into the same cytotoxicity Grade 0-1 (along with all current biomedical alloys).…”

Section: Zr Systemsmentioning

confidence: 99%

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Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

et al. 2016

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Their inherent lack of dislocations and hence slip planes leads to exceptionally high strength and elasticity, approaching the theoretical limit. While oxide glasses and ceramics exhibit low toughness and brittle failure, BMGs can display toughness comparable to crystalline metals. [ 2 ] The lack of grain structure means that BMGs are homogeneous and exhibit isotropic behavior, even at sub-micrometer length scales, and, without grain boundaries or precipitates as oxidation sites, corrosion rates are significantly reduced compared to conventional metals.BMGs soften above an alloy-specifi c glass-transition temperature ( T g ) before eventual, time-dependent, crystallization at a higher, crystallization temperature ( T x ). In this supercooled liquid region (SCLR) between T g and T x , the viscous BMGs may be plastically shaped under low applied forces using polymer-processing techniques, such as hot embossing, extrusion, foaming, and injection and blow moulding, before again cooling to a solid metallic glass. With relatively low processing temperatures and no solidifi cation shrinkage, parts can be formed to netshape with excellent accuracy, and geometries, and surface patterns previously diffi cult in metals can be achieved with ease. [3][4][5][6][7] Such remarkable properties and behavior have led to significant interest in BMGs as engineering materials over the past 20 years, but it is only recently that their potential for use as a biomaterial has been studied. [ 8 ] To date, our understanding of material biocompatiblity has evolved mainly through empirical testing, observing the interaction of materials with cells and host tissue in vitro and in vivo. Materials can induce host responses varying from local and systemic infl ammation, hypersensistivity, toxicity, and even tumorogenesis, meaning that thorough evidence of material safety is required before regulatory approval and clinical translation. We now largely recognise the material characteristics that generate both favorable and undesired host responses, as outlined by Williams, [ 9 ] offering the opportunity for informed material design, while being cognisant that biocompatibility is specifi c to the application and host environment. [ 10 ] The original requirement of fi rst generation "biocompatible" materials was bio-inertness. [ 11 ] This included a resistance to corrosion in the body, and here Ti-and Co-based alloys scored highly. [ 12 ] Less-inert metals, such as Mg, were therefore not deemed suitable, although the ions released on dissolution are generally not harmful to the human body. However, current design requirements for biomaterials, including most recently biometals, include eliciting an appropriate host response, [ 13 ] and this can include the need to biodegrade and resorb. There are potential advantages for BMGs that span applications of With increasing knowledge of the materials science of bulk metallic glasses (BMGs) and improvements in their properties and processing, they have started to become candidate materials for biomedical dev...

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Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

Dai

Tang

et al. 2019

J Biomed Mater Res

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Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms. In our study, when compared with pure Mg, the rare element silver alloyed with yttrium (Ag–Y) could extremely enhance the corrosion resistance of these elements, giving the Ex–Mg–1Ag–1Y alloy better anticorrosion rates. Here, we implanted the Ex–Mg–1Ag–1Y alloy and pure Mg and Ti alloy in vivo around tumors in nude mice (BALB/c). Notably, the local tumor weight in Mg alloy and pure Mg groups were much smaller than that in Ti alloy group in 36 days after surgery (6.59 ± 0.70, 6.76 ± 0.62, and 8.54 ± 0.56 g), while the general scores of lung metastasis in Mg alloy and pure Mg groups were also lower than Ti alloy group (64.50 ± 7.64, 62.73 ± 7.84, and 87.60 ± 9.43). Therefore, the Mg and Ex–Mg–1Ag–1Y alloy, both demonstrated resisting effects against local tumor growth and pulmonary metastasis, which could be performed by changing the extracellular acidosis microenvironment, elevating the Mg concentration, suppressing C–X–C chemokine receptor type 4 (CXCR4) levels, and increasing prostacyclin (PGI2) synthesis. Our work revealed that the Ex–Mg–1Ag–1Y alloy may be a promising orthopedic implant for treating osteosarcoma due to its better corrosion resistance and antitumor attributes. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2537–2548, 2019.

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In vitro and in vivo biocompatibility of an Ag-bearing Zr-based bulk metallic glass for potential medical use

Cited by 41 publications

References 68 publications

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

A Review of Additive Mixed-Electric Discharge Machining: Current Status and Future Perspectives for Surface Modification of Biomedical Implants

Bulk Metallic Glasses for Implantable Medical Devices and Surgical Tools

Evaluation of the mechanisms and effects of Mg–Ag–Y alloy on the tumor growth and metastasis of the MG63 osteosarcoma cell line

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