In vitro and in vivo antidiabetic activity of isolated fraction of Prosopis cineraria against streptozotocin-induced experimental diabetes: A mechanistic study

Soni, Lokesh; Dobhal, M. P.; Arya, Dharmendra; Bhagour, Kiran; Parasher, Pradeep

doi:10.1016/j.biopha.2018.09.099

Cited by 43 publications

(32 citation statements)

References 28 publications

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“…Evidences from previous studies have established a strong link between hyperlipidemia and diabetes. The levels of TG, TC, and LDL‐C are increased and the HDL‐C levels reduced during diabetes (Soni et al, 2018). Elevated lipids in diabetic conditions increases the likelihood of cardiovascular diseases (Stumvoll, Nurjhan, Perriello, Dailey, & Gerich, 1995).…”

Section: Discussionmentioning

confidence: 99%

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

2020

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The antidiabetic properties of Tiliacora triandra ethanol extract in diabetic rats induced with high‐fat diet (HFD)/streptozotocin (STZ) was investigated. Rats were fed with HFD for 4 weeks to induced insulin resistance, and thereafter administered with 35 mg/kg of STZ to induce diabetes. Diabetic rats received 100 and 400 mg/kg of T. triandra daily for 30 days. The body weight, blood glucose level, food and fluid intake were monitored. Furthermore, biochemical and histological assessment was performed to evaluate the hypoglycemic effect of the extract in the treated rats. T. triandra significantly decreased the blood glucose level, increased the body weight and insulin secretion. Furthermore, T. triandra attenuated hyperlipidemia, improved liver and kidney functions of treated diabetic rats. Thus, T. triandra could effectively attenuate diabetes and it complications. Practical applications Tiliacora triandra is a common vegetable consumed in Thailand and Laos. It is traditionally employed in the treatment of fever, cancer, malaria, and diabetes. The extract from the aerial part was investigated for its antidiabetic properties. The results obtained provides important pharmacological information that supports the use of T. triandra in management of diabetes.

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Section: Discussionmentioning

confidence: 99%

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

2020

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“…The biochemical parameters were analysed with the blood collected by retro orbital puncture (Cholesterol, Triglycerides, HDL & LDL). After the treatment the rats weresacrificed by cervical decapitation and the histopathology of the pancreas was investigated [24][25][26][27][28][29][30][31]. The results were as shown in the table 1-3 and graph 1-3.…”

Section: Methodsmentioning

confidence: 99%

Experimental evidences of antidiabetic activity of aqueous extract of Cressa cretica L. on streptozotocin induced diabetes in rats

2020

Lett Appl NanoBioSci

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With the emerging worldwide interest in adopting and studying traditional systems of medication and exploiting their potential based on different health care systems, the evaluation of the rich heritage of traditional medicine is essential. From the innumerable plants being researched since time immemorial, Cressa cretica is an important one. The present study discusses the antidiabetic activity of the entire plant of Cressa cretica L. belonging to Convolvulaceae family.From the thorough investigation of the available literature, it was evident that the plant drug possessed traditional anti-diabetic activity. The aqueous extract of the whole plant of Cressa cretica was subjected to streptozotocin induced diabetes model. The physico-metabolic parameters measured were body weight, Triglycerides, Cholesterol, LDL, HDL, and histopathological studies of pancreas were also observed. The obtained results indicate the anti-diabetic activity of Cressa cretica whole plant extract (200 mg/kg and 400 mg/kg) were increase in body weight, HDL level and reductions in levels of TG, TCH, LDL respectively

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“…A marked reduction in blood glucose levels, glycosylated hemoglobin was observed, and it was also able to restore body weight, liver glycogen content and serum insulin level in diabetic rats, in a dose-dependent manner. Furthermore, a decrease in serum lipid profile and elevation in HDL after administration of the chloroform fraction was found, revealing that chloroform fraction has potential to protect from diabetes-associated complications [69]. P. cineraria bark extract antidiabetic effects were also assessed in male Swiss albino mice with alloxan-stimulated diabetes.…”

Section: Antidiabetic Effectsmentioning

confidence: 96%

“…reported impressive results for P. cineraria anti-diabetic potential in which the oral administration of Pci in STZ-induced rats (in a concentration-dependent manner) spectacularly reduced the level of blood glucose, glycosylated hemoglobin and improved serum insulin level, and liver glycogen content in diabetic rats [69]. Studies also indicated that P. glandulosa (Pgl) improved insulin sensitivity STZ-induced diabetic rats [73].…”

Section: Pre-clinical Effectiveness: Paving the Way For Clinical Studiesmentioning

confidence: 99%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

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Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

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In vitro and in vivo antidiabetic activity of isolated fraction of Prosopis cineraria against streptozotocin-induced experimental diabetes: A mechanistic study

Cited by 43 publications

References 28 publications

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

Experimental evidences of antidiabetic activity of aqueous extract of Cressa cretica L. on streptozotocin induced diabetes in rats

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

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