Experimental evidences of antidiabetic activity of aqueous extract of Cressa cretica L. on streptozotocin induced diabetes in rats

Abstract

With the emerging worldwide interest in adopting and studying traditional systems of medication and exploiting their potential based on different health care systems, the evaluation of the rich heritage of traditional medicine is essential. From the innumerable plants being researched since time immemorial, Cressa cretica is an important one. The present study discusses the antidiabetic activity of the entire plant of Cressa cretica L. belonging to Convolvulaceae family.From the thorough investigation of the available literature, it was evident that the plant drug possessed traditional anti-diabetic activity. The aqueous extract of the whole plant of Cressa cretica was subjected to streptozotocin induced diabetes model. The physico-metabolic parameters measured were body weight, Triglycerides, Cholesterol, LDL, HDL, and histopathological studies of pancreas were also observed. The obtained results indicate the anti-diabetic activity of Cressa cretica whole plant extract (200 mg/kg and 400 mg/kg) were increase in body weight, HDL level and reductions in levels of TG, TCH, LDL respectively