In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

Shi, Guangjiang; Li, Yan; Cao, Qiu-Hua; Wu, Hongxi; Tang, Xin‐Ying; Gao, Xinghua; Yu, Jian‐Qiang; Chen, Zhe; Yang, Yong

doi:10.1016/j.biopha.2018.10.130

Cited by 198 publications

(137 citation statements)

References 114 publications

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“…Some innovative treatment make use of traditional anti-diabetic drugs (insulin and exenatide), cytokines, metabolic modulation, nucleotide and quercetin 16 . Quercetin is an active compound for anti-cancer, anti-bacterial, anti-allergic and analgesic, and improves DN through various signaling pathways, making it a promising compound for the management of these diseases 7,19 . The T2DM recovery from oxidative stress by quercetin was observed in single cell alkaline gel electrophoresis 5 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that quercetin or quercetin liposomes were effective in controlling FBG, BWs, rHI, biochemistry and pathology in STZ induced diabetic animals 22 , which is consistent with our observation. Quercetin can reduce the plasma glucose level because it inhibits intestinal glucose absorption while enhances tissue and organ glucose levels;, quercetin increases insulin secretion by β-cells and protect DM against oxidative stress 7 . Administering quercetin to INS-1 pancreatic β-cells potentiated insulin secretion through enhanced glucose metabolism and protected β-cells against oxidative damages 24 .…”

Section: Discussionmentioning

confidence: 99%

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Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

Tang

Zhang

et al. 2020

Sci Rep

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The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model. DN rats randomly received one of the following treatments for 8 weeks: blank treatment (DN), free quercetin (Que), pegylated liposomes (PEGL) and pegylated quercetin liposomes (Q-PEGL). A group of healthy rats served as the normal control. The fasting blood glucose (FBG), body weights (BWs), renal hypertrophy index (rHI), serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments. Que and Q-PEGL significantly improved DN biochemistry and pathological changes, although the treated rats still had some symptoms of DN. The therapeutic effect of Q-PEGL surpassed that of Que. Pegylated quercetin liposomes allow maintaining higher quercetin concentrations in plasma than non-encapsulated quercetin. In conclusion the use of quercetin liposomes allows to reduce disease symptoms in a rat model of DN.Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to impaired body's ability to produce or respond to the hormone insulin 1 . Diabetic nephropathy (DN) is a microvascular complication of DM and causes long-term or end-stage renal disease 2 . Multifactorial interaction between lipid disorders, oxidative stress, renal hemodynamic changes, polyol activation, inflammatory pathways, and mitogen-activated protein kinase signaling pathways are involved in the pathophysiology of DN 3,4,7 . Therefore, strong antioxidants could potentially serve as treatments to diabetes related diseases 5 Quercetin (C 15 H 10 O 7 ,3′,4′,5,7-pentahydroxyflavone) is a potent dietary bioflavonoid found in diverse fruits, seeds, and vegetables such as legumes, apples, and chili peppers 4-7 . Pharmacological studies in humans show that quercetin has multiple biological functions including circulation system protection, anti-allergic, anti-inflammatory, anti-cancer, anti-diabetes, and cataract prevention 7 . Another important attribution of quercetin is to reduce aldose reductase, which is an enzyme that converts glucose to sorbitol through polyol pathway 5 .Natural quercetin has poor water solubility, therefore, quercetin liposomes are laboratory-prepared to improve its solubility and in vivo absorbability 7-9 . Liposomes are the most studied particle carrier systems allowing sustained release, and have the potential of enhancing the oral bioavailability of proteins and peptides 10 . Liposomes are small spherical lipid vesicles, composed of phospholipids and cholesterol, characterized on size, number of lamellae, and inner/outer phases 11,12 . Liposomes have good cell compatibility, reduce drug toxicity, improve drug stability and function for a long time 13 , and have been used to deliver drugs including antibiotic, antifungal, and cytotoxic agents 14 . Coating inert biocompatible polymers, such as PEG, on the liposom...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

Tang

Zhang

et al. 2020

Sci Rep

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“…Flavonoids and extracts rich in flavonoids from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, and cocoa have been widely studied as possible antidiabetic agents. Quercetin was the most widely investigated flavonoid in the literatures for the in vivo and cellular anti‐diabetic effects in animal and cell models (Shi et al., 2019), followed by kaempferol (Alkhalidy et al., 2018), luteolin (Sangeetha, 2019), myricetin (Li et al., 2017), and naringenin (Den Hartogh & Tsiani, 2019). Compared with these aglycones, flavonoid O ‐glycosides shown less antidiabetic potential (Xiao, 2017).…”

Section: Mechanisms Of Dietary Polyphenols As Antidiabetic Agentsmentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published

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“…In recent years, quercetin has become a rising concern in nutritional and therapeutic potential, owning to its multiple pharmacological effects (Russo, Spagnuolo, Tedesco, Bilotto, & Russo, ). In addition to antitumor, antiobesity, antihypertensive, and significant heart‐related benefits, a large number of in vivo studies have shown that quercetin had a strong potential for antidiabetes and its complications (Bule, Abdurahman, Nikfar, Abdollahi, & Amini, ; Hu et al, ; Lu et al, ; Marunaka et al, ; Patel et al, ; Shi et al, ; Y. Zhao et al, ; X. Zhu, Cheng, et al, ; Y. Zhu, Teng, et al, ). It has been found that quercetin prevents diabetes mellitus by decreasing blood glucose via enhancing insulin sensitivity and stimulating insulin secretion from β cells (Gaballah, Zakaria, Mwafy, Tahoon, & Ebeid, ; Jeong, Kang, Choi, Kim, & Kim, ).…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

Yang

Cai

et al. 2019

Phytotherapy Research

144

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Multiphase pathological processes involve in Type 2 diabetes (T2DM)‐induced nonalcoholic fatty liver disease (NAFLD). However, the therapies are quite limited. In the present study, the hepatoprotective effects and underlying mechanisms of quercetin in T2DM‐induced NAFLD were investigated. T2DM‐induced NAFLD and quercetin treatment models were established in vivo and in vitro. The results revealed that quercetin alleviated serum transaminase levels and markedly reduced T2DM‐induced histological alterations of livers. Additionally, quercetin restored superoxide dismutase, catalase, and glutathione content in livers. Not only that, quercetin markedly attenuated T2DM‐induced production of interleukin 1 beta, interleukin 6, and TNF‐α. Accompanied by the restoration of the increased serum total bile acid (p = .0001) and the decreased liver total bile acid (p = .0005), quercetin could reduce lipid accumulation in the liver of db/db mice. Further mechanism studies showed that farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathways was involved in quercetin regulation of lipid metabolism in T2DM‐induced NAFLD. In high D‐glucose and free fatty acid cocultured HepG2 cells model, quercetin eliminated lipid droplets and restored the upregulated total cholesterol and triglyceride levels. Similar to the findings in mice, quercetin could also activate farnesoid X receptor 1/Takeda G‐protein‐coupled receptor 5 signaling pathway. These findings suggested that quercetin might be a potentially effective drug for the treatment of T2DM‐induced NAFLD.

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In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

Cited by 198 publications

References 114 publications

Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

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