In-vitro and in-vivo, cytotoxicity evaluation of cast functionally graded biomaterials for dental implantology

El‐Hadad, Shimaa; Safwat, Engie M.; Sharaf, Nehal F.

doi:10.1016/j.msec.2018.09.003

Cited by 20 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This linear trend can also be seen between 35 and 50 h at 850°C. It is obvious that the oxidation rate increases with time at all the oxidation temperatures, except 650°C, where the oxidation rate decreases above 40 h. The oxidation kinetics in these experiments were found to obey the following equation [5,[28][29][30] :…”

Section: Oxidation Kineticsmentioning

confidence: 77%

“…[5] Since Ti67 alloy becomes superplastic when hot worked due to formation of large β grains and the volume fraction of α/β depends on the working temperature, studying the effect of oxidation at high temperatures on the alloy microstructure is necessary. Recently, Ti67 alloy has been developed to replace Ti64 due to the reported toxicity of the elemental V. [28] However, few studies have been conducted on the behavior of this alloy under prolonged thermal oxidation conditions. The thermal oxidation process is used to prepare bioactive surfaces as mentioned previously.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Investigating the thermal oxidation behavior of Ti–6Al–7Nb alloy in dry air

Mohamed

Elmomen

El‐Hadad

2022

Materials & Corrosion

Self Cite

View full text Add to dashboard Cite

The thermal oxidation behavior of a forged Ti–6Al–7Nb (Ti67) alloy was investigated in dry air conditions. The alloy specimens were oxidized for 50 h at different temperatures (650°C, 750°C, and 850°C) and the oxidation kinetics were analyzed. The microstructure of Ti67 after oxidation and the different phases and compounds were identified. A parabolic equation based on weight gain was used to define the oxidation rate. The parabolic rate constant increased from 1.10 × 10−8 at 650°C to 2.10 × 10−8 and 1.53 × 10−7 g2/(cm4·h) at 750°C and 850°C, respectively. At 650°C, the oxidation behavior resumed the parabolic behavior until 40 h, a breakaway phenomenon. At 750°C, a linear behavior was observed in the periods of 20–50 h. This linear trend appeared also after 35–50 h at 850°C. The activation energy was found to be 238.4 kJ/mole. At the lowest oxidation temperature (650°C), a disconnected oxide layer was observed. These variations in the response of Ti67 alloy to the different thermal oxidation conditions are worthy of consideration when modifying the surfaces for biomedical applications.

show abstract

Section: Oxidation Kineticsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Investigating the thermal oxidation behavior of Ti–6Al–7Nb alloy in dry air

Mohamed

Elmomen

El‐Hadad

2022

Materials & Corrosion

Self Cite

View full text Add to dashboard Cite

show abstract

“…The scope of biocompatibility encompasses the adaptation by living tissues, proper mechanical properties, easy forming, alloy tarnishing over time (associated with passivation) and its resistance to corrosion [1]. Low biotolerance means that application of the biomaterial may, among others, lead to the occurrence of inflammatory or allergic reactions and carcinogenic potential of corrosion products in certain cases [2,3].…”

Section: Introductionmentioning

confidence: 99%

Changes of cytotoxicity of Ti-6Al-4V alloy made by DMLS technology as effect of the shot peening

Żebrowski¹,

Walczak²,

Drozd³

et al. 2020

Ann Agric Environ Med.

View full text Add to dashboard Cite

Objective. The aim the study was to investigate the impact of the shot peening process on the condition of the surface layer and biological properties of titanium alloy produced by means of the Direct Metal Laser Sintering (DMLS) method. Materials and method. Specimens were prepared by the EOSINT M280 metal sintering laser system. The surfaces were subjected to the shot peening process using three different media, i.e. steel shot, nutshell granules and ceramic beads, after which they were subjected to profilometric analysis, scanning electron microscopic (SEM) observations and energy dispersive X-ray spectroscopy (EDS) tests, as well as to assessment of biological compatibility in terms of cytotoxicity (SH-SY5Y cell lines). Results. The general results obtained from the tests indicate satisfactory biocompatibility of the examined surfaces and that the impact of the shot peening process on the titanium alloy cytotoxicity is acceptable. Conclusions. The lowest cytotoxicity was demonstrated by the surfaces modified by ceramic beads than the nutshells and the biggest steel shot correspondingly. Moreover, the shot peening process carried out by means of CrNi steel and ceramic shot caused the reduction of surface roughness when, for the surface processing by means of nutshell granules, the increase of surface roughness was observed compared with the unmodified surface of titanium alloy samples.

show abstract

“…La parte de carbohidrato consiste en arabinogalactanos del tipo II, caracterizados principalmente por poseer una cadena lineal de D-galactosas unidas mediante enlaces β [1][2][3] sustituida en el carbono 6 por las cadenas laterales de β [1][2][3][4][5][6] D-galactosas [31] .…”

Section: Péptidos Y Proteínasunclassified

“…Sin embargo, hasta el momento ninguna composición uniforme de un biomaterial puede cumplir con todos los requerimientos necesarios para su función [2] Por esta razón, es de gran interés la modificación o funcionalización de los biomateriales sintéticos con diferentes moléculas bioactivas, con el fin de dotarlos de actividades biológicas únicas. Cuando estos materiales funcionalizados entran en contacto por primera vez con los tejidos, el tipo y cantidad moléculas bioactivas de superficie es de gran importancia para la adhesión, proliferación y diferenciación celular [3] .…”

Section: Introductionunclassified

Uso de Biomateriales Funcionalizados con Moléculas Bioactivas en la Ingeniería Biomédica

Reyes-Blas

Olivas–Armendáriz

Martel-Estrada

et al.

View full text Add to dashboard Cite

El artículo expone la importancia del uso de moléculas bioactivas para la funcionalización de biomateriales. Por esta razón, se realizó una revisión de investigaciones actuales y relevantes en diversos buscadores de datos, incluyendo los diferentes tipos de materiales y moléculas bioactivas utilizadas para elaborar biomateriales funcionalizados, con énfasis en los procesos y sus propiedades. Se encontró que el proceso de funcionalización o modificación de la su- perficie expande el camino para adaptar al biomaterial de acuerdo al entorno fisiológico de las células vivas. De esta manera, el proceso mejora la estructura y las funciones de los tejidos y órganos diseñados. Existen una variedad de métodos y moléculas bioactivas disponibles para la funcionalización de los biomateriales, las cuales dependen de la manera en las que las células o tejidos se regeneran. Entre los diferentes materiales para la fabricación de bioma- teriales, las biomoléculas como las proteínas, lípidos, carbohidratos, entre otros, son una de las opciones más utili- zadas debido a la similitud de estas con los sistemas biológicos del cuerpo humano. Finalmente, el artículo también integra algunas de las más prometedoras aplicaciones de moléculas bioactivas incorporadas a los biomateriales.

show abstract

In-vitro and in-vivo, cytotoxicity evaluation of cast functionally graded biomaterials for dental implantology

Cited by 20 publications

References 13 publications

Investigating the thermal oxidation behavior of Ti–6Al–7Nb alloy in dry air

Investigating the thermal oxidation behavior of Ti–6Al–7Nb alloy in dry air

Changes of cytotoxicity of Ti-6Al-4V alloy made by DMLS technology as effect of the shot peening

Uso de Biomateriales Funcionalizados con Moléculas Bioactivas en la Ingeniería Biomédica

Contact Info

Product

Resources

About