In vitro and in vivo corrosion measurements of magnesium alloys

Witte, Frank; Fischer, J.; Nellesen, J.; Crostack, H.‐A.; Kaese, V.; Pisch, A.; Beckmann, Felix; Windhagen, Henning

doi:10.1016/j.biomaterials.2005.07.037

Cited by 1,259 publications

(745 citation statements)

References 7 publications

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“…Although some attempts have been made to correlate in vitro and in vivo results (Li et al, 2014;Li et al, 2012;Shadanbaz et al, 2014;Witte et al, 2006), in general the comparison between different methods is poor (MartinezSanchez et al, 2015). In some cases the immersion testing conditions apply different electrolytes, buffering and solution volume to sample surface ratio (V/S) and, as a result, the comparison with in vivo experiments is hardly possible (Li et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study

Marco

Myrissa²,

Martinelli³

et al. 2017

eCM

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The purpose of this study was to compare short term in vitro and in vivo biodegradation studies with low purity Mg (> 99.94 %), Mg-10Gd and Mg-2Ag designed for biodegradable implant applications. Three in vitro testing conditions were applied, using (i) phosphate buffered saline (PBS), (ii) Hank's balanced salt solution (HBSS) and (iii) Dulbecco's modified eagle medium (DMEM) in 5 % CO 2 under sterile conditions. Gas evolution and mass loss (ML) were assessed, as well as the degradation layer, by elemental mapping and scanning electron microscopy (SEM). In vivo, implantations were performed on male Sprague-Dawley rats evaluating both, gas cavity volume and implant volume reduction by micro-computed tomography (µCT), 7 d after implantation. Samples were produced by casting, solution heat treatment and extrusion in disc and pin shape for the in vitro and in vivo experiments, respectively. Results showed that when the processing of the Mg sample varied, differences were found not only in the alloy impurity content and the grain size, but also in the corrosion behaviour. An increase of Fe and Ni or a large grain size seemed to play a major role in the degradation process, while the influence of alloying elements, such as Gd and Ag, played a secondary role. Results also indicated that cell culture conditions induced degradation rates and degradation layer elemental composition comparable to in vivo conditions. These in vitro and in vivo degradation layers consisted of Mg hydroxide, Mg-Ca carbonate and Ca phosphate.

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Section: Introductionmentioning

confidence: 99%

In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study

Marco

Myrissa²,

Martinelli³

et al. 2017

eCM

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“…Due to such collective properties, Mg based alloys can be employed as biocompatible, bioactive, and biodegradable scaffolds for load-bearing biomedical applications [25,26]. Such characteristics encourage employing biodegradable Mg and Mg alloys as lightweight metals for load bearing orthopaedic implants, which would remain in the body and keep mechanical stability over a time scale of 3-4 months, while the natural bone tissue heals [33,34].…”

mentioning

confidence: 99%

Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

223

110

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“…For single-phase materials, degradation is typically located, resulting in the formation of concavities on the surface of the material [8,10,14]. The presence of a secondary phase, due to impurities, causes a galvanic degradation.…”

Section: Degradabilitymentioning

confidence: 99%

“…The lack of generalized degradation is an important factor in the use of magnesium as a biomaterial, because extended degradability surfaces cause mechanical properties to change. On the other side of the barrier, using a magnetically degraded magnesium biomaterial could lead to the production of gaseous hydrogen in the implant medium and an increase in the local pH that could cause significant effects on surrounding tissues [4,8,10,14,15].…”

Section: Degradabilitymentioning

confidence: 99%

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

Istrate

Vololeniuc

Munteanu

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Based on the biodegradable biomaterial development, there are numerous studies demonstrating partial or total aspects that have ultimately led to their use in many fields, especialy in medicine. This study summarizes the latest information on the development of degradable biomaterials based on magnesium, especially used in in vivo tissue compatibility assessment. The biomaterial compatibility assessment combines with the development of medical devices, this study following evolutionary parameters and integration of implants for human use. One of the most important parameters is the efficiency with which the medical device works near to the maximum potential. In conclusion, our study aims to broadly present the in vivo analysis of biodegradable biomaterials based on magnesium.

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In vitro and in vivo corrosion measurements of magnesium alloys

Cited by 1,259 publications

References 7 publications

In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study

In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study

Porous magnesium-based scaffolds for tissue engineering

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

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