In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy

Amatya, Reeju; Hwang, Seung-Mi; Park, Taehoon; Min, Kyung Up; Shin, Meong Cheol

doi:10.3390/pharmaceutics13060871

Cited by 18 publications

(12 citation statements)

References 49 publications

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“…For example, polyethylene glycol (PEG)-conjugated and starch-coated MNPs (PEG–starch–MNPs) for enhanced photothermal cancer therapy (PTT) were developed. The authors found that plasma half-life of PEG–starch–MNPs was 2.7 h, whereas, to compare, t 1/2 of starch–MNPs was 5.8 min [ 84 ].…”

Section: Intravenously Injected Mnpsmentioning

confidence: 99%

Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

Nowak-Jary

Machnicka

2022

J Nanobiotechnol

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Magnetic iron oxide nanoparticles (MNPs) have been under intense investigation for at least the last five decades as they show enormous potential for many biomedical applications, such as biomolecule separation, MRI imaging and hyperthermia. Moreover, a large area of research on these nanostructures is concerned with their use as carriers of drugs, nucleic acids, peptides and other biologically active compounds, often leading to the development of targeted therapies. The uniqueness of MNPs is due to their nanometric size and unique magnetic properties. In addition, iron ions, which, along with oxygen, are a part of the MNPs, belong to the trace elements in the body. Therefore, after digesting MNPs in lysosomes, iron ions are incorporated into the natural circulation of this element in the body, which reduces the risk of excessive storage of nanoparticles. Still, one of the key issues for the therapeutic applications of magnetic nanoparticles is their pharmacokinetics which is reflected in the circulation time of MNPs in the bloodstream. These characteristics depend on many factors, such as the size and charge of MNPs, the nature of the polymers and any molecules attached to their surface, and other. Since the pharmacokinetics depends on the resultant of the physicochemical properties of nanoparticles, research should be carried out individually for all the nanostructures designed. Almost every year there are new reports on the results of studies on the pharmacokinetics of specific magnetic nanoparticles, thus it is very important to follow the achievements on this matter. This paper reviews the latest findings in this field. The mechanism of action of the mononuclear phagocytic system and the half-lives of a wide range of nanostructures are presented. Moreover, factors affecting clearance such as hydrodynamic and core size, core morphology and coatings molecules, surface charge and technical aspects have been described. Graphical Abstract

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Section: Intravenously Injected Mnpsmentioning

confidence: 99%

Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

Nowak-Jary

Machnicka

2022

J Nanobiotechnol

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“…According to Cretu and coauthors (2021), as IONPs have a high area/volume ratio, magnetization, Van der Waals forces and high surface energy, they tend to aggregate (Crețu et al, 2021). Therefore, these nanoparticles can have their surface stabilized, coated and/or functionalized, which provides greater applicability (Amatya et al, 2021;Crețu et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

“…As the behavior of IONPs in the biomedical field is influenced by three variables, including morphology, size and surface characteristics, experimental parameters such as the presence of surfactants, Fe 2+ /Fe 3+ ratio, salt type, pH control, electrical force, nature of the alkaline agent (NaOH, Na2CO3, NH4OH), stirring rate, nitrogen or argon flow in the system, and temperature or time of reaction are some of the factors that can affect the physical characteristics of nanoparticles and influence their biological properties, as the rate of blood circulation, cellular absorption, and biodistribution (Hernández-Hernández et al, 2020;Crețu et al, 2021;Amatya et al, 2021). The shape, size, crystal structure, chemical composition, and dispersibility of nanoparticles directly affects their physical and chemical properties, and consequently also the performance of such materials in a bunch of applications (Shabatina et al, 2020;Ajinkya et al, 2020;Zhu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Síntese de nanopartículas de óxido de ferro estabilizadas com citrato de sódio e TMAOH

Cândido

Rost

Ferreira

et al. 2022

RSD

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As nanopartículas de óxido de ferro (IONPs) representam uma classe de nanomateriais magnéticos e biocompatíveis que têm sido amplamente utilizados em pesquisas e aplicações médicas, como estudos de hipertermia, como agentes de contraste para ressonância magnética, biossensores, entre outros. Entretanto, sua aplicação depende de fatores como, morfologia, tamanho e propriedade de superfície estejam ajustados. As IONPs podem ser obtidas por diferentes métodos de síntese, no entanto, a coprecipitação química representa uma rota de síntese mais simples, fácil e rápida, na qual soluções aquosas de precursores contendo íons ferro (Fe3+) e ferroso (Fe2+) são alcalinizadas sob controle de temperatura e pH. Este estudo propõe sintetizar nanopartículas de óxido de ferro pelo método de coprecipitação química e estabilizá-las com citrato de sódio (IONPs-CIT) e hidróxido de tetrametilamônio (IONPs-TMAOH). Além disso, caracterizar o diâmetro hidrodinâmico e o Potencial Zeta das amostras por espalhamento dinâmico da luz. A citotoxicidade das IONPs-CIT na linhagem celular MDA-MB-468 foi avaliada através da análise da atividade mitocondrial.

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“…Amatya et al studied the photothermal activity of iron oxide nanoparticles modified with PEG and starch to prevent aggregation and improve biocompatibility [160]. The modified nanoparticles were employed as PTT agents to treat cancer under an 885 nm NIR I laser.…”

Section: Exposure Limits Correction Factor Cmentioning

confidence: 99%

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

Voronin

Abalymov

Svenskaya

et al. 2021

IJMS

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The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

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In Vitro and In Vivo Evaluation of PEGylated Starch-Coated Iron Oxide Nanoparticles for Enhanced Photothermal Cancer Therapy

Cited by 18 publications

References 49 publications

Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

Síntese de nanopartículas de óxido de ferro estabilizadas com citrato de sódio e TMAOH

Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

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