In vitro and in vivo antimicrobial activities of extracts and constituents derived from Desmodium styracifolium (Osb.) Merr. against various phytopathogenic fungi and bacteria

Dang, Quang Le; Thi, Hoai Thu; Choi, Gyung Ja; Nguyen, Minh Van; Vu, Hoang Dinh; Phạm, Gia Vũ; Ho, Cuong Tu; Nguyen, Xuan Canh; Vu, Van Hanh; Tran, Thang Dinh; Nghiêm, Đức Trọng; Nguyen, Thanh Thuy

doi:10.1016/j.indcrop.2022.115521

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Physcion is one of the common anthraquinone compounds that extensively exists in various plants. Increasing evidence suggested that physcion effectively inhibited the growth of phytopathogenic fungi and bacteria [7,11,12]. Osthole, a natural product derived from medicinal plants including Cnidium monnieri and Angelica, displayed multiple pharmacological actions such as immunomodulation and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Antibacterial Activity of 4-Allylbenzene-1,2-diol from Piper austrosinense

Wang

Fan

et al. 2023

Molecules

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Isolation for antibacterial compounds from natural plants is a promising approach to develop new pesticides. In this study, two compounds were obtained from the Chinese endemic plant Piper austrosinense using bioassay-guided fractionation. Based on analyses of 1H-NMR, 13C-NMR, and mass spectral data, the isolated compounds were identified as 4-allylbenzene-1,2-diol and (S)-4-allyl-5-(1-(3,4-dihydroxyphenyl)allyl)benzene-1,2-diol. 4-Allylbenzene-1,2-diol was shown to have strong antibacterial activity against four plant pathogens, including Xanthomonas oryzae pathovar oryzae (Xoo), X. axonopodis pv. citri (Xac), X. oryzae pv. oryzicola (Xoc) and X. campestris pv. mangiferaeindicae (Xcm). Further bioassay results exhibited that 4-allylbenzene-1,2-diol had a broad antibacterial spectrum, including Xoo, Xac, Xoc, Xcm, X. fragariae (Xf), X. campestris pv. campestris (Xcc), Pectobacterium carotovorum subspecies brasiliense (Pcb) and P. carotovorum subsp. carotovorum (Pcc), with minimum inhibitory concentration (MIC) values ranging from 333.75 to 1335 μmol/L. The pot experiment showed that 4-allylbenzene-1,2-diol exerted an excellent protective effect against Xoo, with a controlled efficacy reaching 72.73% at 4 MIC, which was superior to the positive control kasugamycin (53.03%) at 4 MIC. Further results demonstrated that the 4-allylbenzene-1,2-diol damaged the integrity of the cell membrane and increased cell membrane permeability. In addition, 4-allylbenzene-1,2-diol also prevented the pathogenicity-related biofilm formation in Xoo, thus limiting the movement of Xoo and reducing the production of extracellular polysaccharides (EPS) in Xoo. These findings suggest the value of 4-allylbenzene-1,2-diol and P. austrosinense could be as promising resources for developing novel antibacterial agents.

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Section: Introductionmentioning

confidence: 99%

Isolation, Characterization and Antibacterial Activity of 4-Allylbenzene-1,2-diol from Piper austrosinense

Wang

Fan

et al. 2023

Molecules

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“…GN supplements are on the market particularly in Asia due to their health promoting effects. Evidence is piling up that GN has anti-inflammatory ( 6 ), anticancer ( 7 , 8 ), anti-diabetic ( 9 ), anti-hyperlipidemic ( 10 ), antiviral ( 8 , 11 ), antimicrobial ( 12 ), antifungal ( 13 ), cardioprotective ( 2 , 14 ), nephroprotective ( 15 ), antioxidant ( 16 , 17 ), and anti-obesity ( 18 ) properties among others. Surprisingly, recent studies revealed that GN is a potential endocrine disruptor (ED) that interferes with estrogen receptors (ERs) hence interfering with the endocrinology system ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

The obesogenic side of Genistein

Xiang,

Mlambo,

Dube

et al. 2023

Front. Endocrinol.

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Genistein (GN) has been highly recommended for its medicinal properties like anticancer, antidiabetic, antihyperlipidemic, antiviral, and antioxidant activities among others. Recently, scientists realized that Genistein is an endocrine disruptor. It is an obesogen that interferes with the endocrine system causing obesity through many mechanisms like inducing adipocyte differentiation, lipid accumulation, and transformation of some stem cells into adipocytes (bone marrow mesenchymal stem cells for example) in vitro. Animal studies show that GN upregulates genes associated with adipogenesis like CCAAT/enhancer binding protein alpha (Cebpα), CCAAT/enhancer binding protein beta (Cebpβ), and PPARγ. In silico studies reveal a strong binding affinity for estrogen receptors. All these findings were contingent on concentration and tissues. It is beyond dispute that obesity is one of the most frustrating medical conditions under the sun. The pathophysiology of this disease was first attributed to a high-calorie diet and lack of physical activity. However, studies proved that these two factors are not enough to account for obesity in both children and adults. This mini review highlights how Genistein interaction with the peroxisome proliferator-activated receptor gamma protein can cause obesity.

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Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity

et al. 2023

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In vitro and in vivo antimicrobial activities of extracts and constituents derived from Desmodium styracifolium (Osb.) Merr. against various phytopathogenic fungi and bacteria

Cited by 5 publications

References 29 publications

Isolation, Characterization and Antibacterial Activity of 4-Allylbenzene-1,2-diol from Piper austrosinense

Isolation, Characterization and Antibacterial Activity of 4-Allylbenzene-1,2-diol from Piper austrosinense

The obesogenic side of Genistein

Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity

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