Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity

Dang, Quang Le; Hoàng, Vũ Đình; Nguyen, Van Minh; Choi, Gyung Ja; Hoa, Le Thi Phuong; Dung, Dương Thị; Kiệm, Phan Văn; Cuong, Nguyen Xuan; De, Tran Quang; Nguyen, Quoc Cuong; Nghiêm, Đức Trọng; Quang, Đặng Ngọc

doi:10.1016/j.fitote.2023.105609

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…The effect of these fractions on the suppression of Cl − transport is not obvious. The n -BuOH fraction was further chemically investigated to obtain 12 compounds including three previously unreported phenols: 3′- O - β - d -glucopyranosyl-isohomoarbutin ( 1 ), 4′- O - β - d -glucopyranosyl-isohomoarbutin ( 2 ), and 5-5′-dehydro-di (2-methyl-4-hydroxy-phenyl-1- O - β - d -glucopyranoside) ( 3 ); one new cyclohexanol: (1 R ,3 R ,4 R )-3-methylcyclohexanol β - d -glucopyranoside ( 4 ); and one first named new phenol: 3-[( E )-4-hydroxy-3-methyl-2-butenyl]-4-hydroxy-2-methylphenyl- O - β - d -glucopyranoside ( 5 ) [ 14 ]; together with: isohomoarbutin ( 6 ) [ 15 ], quercetin ( 7 ) [ 16 ], quercitrin ( 8 ) [ 17 ], isoquercitrin ( 9 ) [ 17 ], hyperoside ( 10 ) [ 18 ], kaempferol ( 11 ) [ 19 ], and juglanin ( 12 ) [ 20 ] ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Constituents of Chimaphila japonica and Their Diuretic Activity

Yu,

Hu,

Liu

et al. 2024

Molecules

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Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and compounds 9 and 10 were reported in C. japonica for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds 4, 7, and 11 exhibited potent diuretic activity. The modes of interaction between the selected compounds and the target diuretic-related WNK1 kinase were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential diuretic activities of metabolites in C. japonica.

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Section: Resultsmentioning

confidence: 99%

Constituents of Chimaphila japonica and Their Diuretic Activity

Yu,

Hu,

Liu

et al. 2024

Molecules

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“…are recognized for their medicinal value, often employed in treating various ailments such as cardiovascular syndromes, hepatitis, pneumonia, nephritis, and parasitic diseases. Recent pharmacological studies have revealed the diverse therapeutic effects of Desmodium plants, including their antioxidant, anti-inflammatory, cardioprotective, hepatoprotective, sedative, and antipyretic properties [8,[10][11][12][13]. Their phytoconstituents include flavonoids, phenylpropanoids, phenolic compounds, and alkaloids, with the former two being the main classes [8,10].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Neuroprotective Potential of Desmodium Species: Insights into Radical Scavenging Capacity and Mechanisms against 6-OHDA-Induced Neurotoxicity

Chang,

Lien,

Hsueh

et al. 2024

Plants

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In this study, we collected seven prevalent Taiwanese Desmodium plants, including three species with synonymous characteristics, in order to assess their antioxidant phytoconstituents and radical scavenging capacities. Additionally, we compared their inhibitory activities on monoamine oxidase (MAO) and 6-hydroxydopamine (6-OHDA) auto-oxidation. Subsequently, we evaluated the neuroprotective potential of D. pulchellum on 6-OHDA-induced nerve damage in SH-SY5Y cells and delved into the underlying neuroprotective mechanisms. Among the seven Desmodium species, D. pulchellum exhibited the most robust ABTS radical scavenging capacity and relative reducing power; correspondingly, it had the highest total phenolic and phenylpropanoid contents. Meanwhile, D. motorium showcased the best hydrogen peroxide scavenging capacity and, notably, D. sequax demonstrated remarkable prowess in DPPH radical and superoxide scavenging capacity, along with selective inhibitory activity against MAO-B. Of the aforementioned species, D. pulchellum emerged as the frontrunner in inhibiting 6-OHDA auto-oxidation and conferring neuroprotection against 6-OHDA-induced neuronal damage in the SH-SY5Y cells. Furthermore, D. pulchellum effectively mitigated the increase in intracellular ROS and MDA levels through restoring the activities of the intracellular antioxidant defense system. Therefore, we suggest that D. pulchellum possesses neuroprotective effects against 6-OHDA-induced neurotoxicity due to the radical scavenging capacity of its antioxidant phytoconstituents and its ability to restore intracellular antioxidant activities.

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Desmodinosides A-E: New Flavonoid C-glycosides from Desmodium heterocarpon var. stigosum with hepatoprotective and antifungal activity

Cited by 2 publications

References 16 publications

Constituents of Chimaphila japonica and Their Diuretic Activity

Constituents of Chimaphila japonica and Their Diuretic Activity

Exploring the Neuroprotective Potential of Desmodium Species: Insights into Radical Scavenging Capacity and Mechanisms against 6-OHDA-Induced Neurotoxicity

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