In vitro and in vivo targeting effect of folate decorated paclitaxel loaded PLA–TPGS nanoparticles

Ha, Phuong Thu; Nam, Nguyễn Hoài; Bui, Thuc Quang; Sơn, Hồ Anh; Toàn, Nguyễn Lĩnh; Quang, Duong Tuan

doi:10.1016/j.jsps.2015.02.002

Cited by 33 publications

(20 citation statements)

References 17 publications

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“…Previous studies using similar nanoparticles showed that PTX-loaded copolymer PLA-TPGS-induced apoptosis in HepG2 cells [26]. In addition, folate decorated PTXloaded PLA-TPGS nanoparticles are more effective targeting at cancer cells both in vitro and in vivo than PTX alone [27]. A recent study demonstrated that TiO 2 , SiO 2 , and hydroxyapatite nanoparticles could strengthen intracellular tension and retard cellular migration [28].…”

Section: Discussionmentioning

confidence: 99%

Encapsulated paclitaxel nanoparticles exhibit enhanced anti-tumor efficacy in A549 non-small lung cancer cells

Huang

Zang

Wang

et al. 2015

ABBS

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In the present study, paclitaxel (PTX) were encapsulated with polyethylene glycol (PEG)-polylactide (PLA)/D-α tocopheryl polyethylene glycol 1000 succinate (TPGS) (PEG-PLA/TPGS) and the enhanced anti-tumor activity of this PTX mixed micelles (PTX-MM) was evaluated in lung cancer cells. The PTX-MM prepared by a solvent evaporation method was demonstrated to have high drug-loading efficiency (23.2%), high encapsulation efficiency (76.4%), and small size (59 nm). In vitro release assay showed the slow release behavior of PTX-MM, suggesting the good stability of the PTX-MM essential for long circulation time. In vitro kinetics assay demonstrated that PTX-MM could promote absorption and increase relative bioavailability. The anti-cancer efficiency of PTX-MM was also examined by both in vitro and in vivo studies. PTX-MM exhibits obvious cytotoxicity against lung cancer cells with much lower IC 50 value when compared with commercial formulated PTX or PTX + TPGS. The xenograft tumor model studies on nude mice indicated that PTX-MM inhibits tumor growth more effectively than other formulations. It was also found that most of mixed micelles were integral in tumor site to exhibit anti-cancer activity. Our results suggested that the use of PTX-MM as an anti-cancer drug may be an effective approach to treat lung cancer.

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Section: Discussionmentioning

confidence: 99%

Encapsulated paclitaxel nanoparticles exhibit enhanced anti-tumor efficacy in A549 non-small lung cancer cells

Huang

Zang

Wang

et al. 2015

ABBS

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“…Paclitaxel is one of the most effective chemotherapeutic agents but it has poor water solubility and low therapeutic index so it needs an urgent solution to increase therapeutic efficacy of paclitaxel. According to this subject, in 2015, Thu et al [78] Figure 10). Barba group synthesized new nanovectors based on copolymer of α, β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and PLA to control release of lipophilic drugs [80].…”

Section: Application Of Biodegradable Nanostructure Polymersmentioning

confidence: 98%

Polymeric nanoparticles: Recent development in synthesis and application

Mallakpour¹,

Behranvand²

2016

Express Polym. Lett.

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Abstract. Nanosized particles have attractive characteristics, which have received considerable attention in the last decade. Polymeric nanoparticles (PNP)s are solid particles or particulate dispersions with size in the range of 10-1000 nm. Due to the very small size, the surface area is very large so the percentage of atoms or molecules on the surface is significantly increased, which is expected to have extensive applications in various fields such as drug delivery systems, biosensors, catalysts, nanocomposites, agriculture and environment. The aim of the present paper is to critically review enhancement in the field of synthesis and different application of novel PNPs in various area from drug delivery to composite fabrication. Literature sources were mainly taken from the publications of 2011 and later; though, for a basic depiction of the structural principles, older publications have also been cited. Vol.10, No.11 (2016) 895-913 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2016.84 * Corresponding author, e-mail: mallak@cc.iut.ac.ir © BME-PT of these methods as low cost and safe ways should be highlighted. Furthermore, their importance according to their applications discusses. We will also show some properties of them such as morphology and biological activity. Keywords: biopolymers, biocomposites, polymeric nanoparticles, drug delivery systems, biosensors eXPRESS Polymer Letters

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“…Vinyl Prolidon Poly -Chloride Stearoin -Chitosan [7]; PEG-Folic Acid [8]; Chitosanoligosaccharides-Au [9]; and Folate -PLA-TPGS [10]. Recently, there are no research have reported cellulose of cassava baggase as delivery of paclitaxel.…”

Section: Certain Polymers Have Been Used As Paclitaxel Delivery Includementioning

confidence: 99%

“…Induction of paclitaxel against cancer cells also causes apoptosis; cell fatality is mediated by caspase (one of cysteine protease). Morphologically, during apoptosis occurs chromatics condensation [9][10]. In the leukemia, paclitaxel induce caspase so causes cell death in the range of 16-36 hours [16].…”

Section: Mechanism Of Paclitaxel Kill Cancermentioning

confidence: 99%

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

Nahrowi

Setiawan

Noviany

et al. 2019

JESR

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Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

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In vitro and in vivo targeting effect of folate decorated paclitaxel loaded PLA–TPGS nanoparticles

Cited by 33 publications

References 17 publications

Encapsulated paclitaxel nanoparticles exhibit enhanced anti-tumor efficacy in A549 non-small lung cancer cells

Encapsulated paclitaxel nanoparticles exhibit enhanced anti-tumor efficacy in A549 non-small lung cancer cells

Polymeric nanoparticles: Recent development in synthesis and application

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

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