In vitro and in vivo antipseudomonal activity, acute toxicity, and mode of action of a newly synthesized fluoroquinolonyl ampicillin derivative

Lin, Wen Po; Ji, Dar Der; Shiau, Chia Yang; Yang, Tse Chun; Yang, Yung Wen; Tsou, Tai Li; Tang, Shang Tao; Chen, Chi Hsing; Liu, Yu Tien

doi:10.1016/s0022-2143(03)00112-4

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Work of the past few years identified a large number of additional genes from various organisms that encode enzymes exhibiting AHL‐inactivating activities. More importantly, it was also shown that heterologous expression of these enzymes in P. aeruginosa not only reduces production of virulence factors but also attenuates the pathogenicity of the organism (Reimmann et al ., 2002; Lin et al ., 2003). It is noteworthy in this context that P. aeruginosa harbours an endogenous AHL acylase, PvdQ, which specifically degrades 3‐oxo‐C 12 ‐HSL and other long‐acyl but not C 4 ‐HSL or other short‐acyl AHLs (Huang et al ., 2003).…”

Section: Exploiting Quorum Sensing For Antimicrobial Therapymentioning

confidence: 99%

Quorum sensing: the power of cooperation in the world of Pseudomonas

Juhas

Eberl

Tümmler

2005

Environmental Microbiology

353

285

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SummaryWork over the past few years has provided evidence that quorum sensing is a generic regulatory mechanism that allows bacteria to launch a unified, coordinated response in a population density-dependent manner to accomplish tasks which would be difficult, if not impossible, to achieve for a single bacterial cell. Quorum sensing systems are widespread among pseudomonads and the one of the human opportunistic pathogen Pseudomonas aeruginosa belongs to the most extensively studied cell-to-cell communication systems. In this organism, quorum sensing is highly complex and is made up of two interlinked Nacyl homoserine lactone (AHL)-dependent regulatory circuits, which are further modulated by a non-AHLrelated signal molecule and numerous regulators acting both at the transcriptional and posttranscriptional level. This genetic complexity may be one of the key elements responsible for the tremendous environmental versatility of P. aeruginosa . Work of the past few years showed that quorum sensing is essential for the expression of a battery of virulence factors as well as for biofilm formation in P. aeruginosa and thus represents an attractive target for the design of novel drugs for the treatment of P. aeruginosa infections. Furthermore, the cell-to-cell communication ability was also demonstrated in a number of additional pseudomonads.

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Section: Exploiting Quorum Sensing For Antimicrobial Therapymentioning

confidence: 99%

Quorum sensing: the power of cooperation in the world of Pseudomonas

Juhas

Eberl

Tümmler

2005

Environmental Microbiology

353

285

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“…Therefore, in this study we used the core structural elements of ß-lactam antibiotics, the 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid, as coupling partners for laccase-mediated reactions. The aim was to change the C-6 and C-7 substituent respectively, as has been previously achieved (Dabernat et al 2004;Lam et al 2015;Lin et al 2003;Lopez et al 2004;Potron et al 2013;Springer et al 2003;Stachulski 1985), but by using a novel synthesis approach.…”

Section: Introductionmentioning

confidence: 99%

Laccase-catalyzed derivatization of 6-aminopenicillanic, 7-aminocephalosporanic and 7-aminodesacetoxycephalosporanic acid

Mikolasch¹,

Hammer

Witt

et al. 2020

AMB Expr

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Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of 6-aminopenicillanic, 7-aminocephalosporanic, and 7-aminodesacetoxycephalosporanic acid with 2,5-dihydroxybenzoic acid derivatives to form new penicillin and cephalosporin structures, respectively. The heteromolecular hybrid dimers are formed by nuclear amination of the p-hydroquinones with the primary amines and inhibited in vitro the growth of Staphylococcus species, including some multidrug-resistant strains.

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