In vitro and in vivo studies of novel fabricated bioactive dressings based on collagen and zinc oxide 3D scaffolds

Balaure, Paul Cătălin; Holban, Alina Maria; Grumezescu, Alexandru Mihai; Mogoşanu, George Dan; Bălşeanu, Tudor Adrian; Stan, Miruna Silvia; Dinischiotu, Anca; Volceanov, Adrian; Mogoantă, Laurențiu

doi:10.1016/j.ijpharm.2018.12.063

Cited by 75 publications

(45 citation statements)

References 20 publications

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“…Aiming to provide a better alternative for treating burns while also reducing the incidence of associated sepsis, Balaure et al described the synthesis and characteristics of dressings that incorporated ZnONPs in a bioresorbable matrix composed of collagen and 1% orange essential oil. The wound dressing accelerated wound closure and prevented bacterial growth both in vitro and in vivo, while also displaying excellent biocompatibility and reduced cytotoxicity [31].…”

Section: Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials for Wound Healing and Infection Control

et al. 2019

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Wound healing has been intensely studied in order to develop an “ideal” technique that achieves expeditious recovery and reduces scarring to the minimum, thus ensuring function preservation. The classic approach to wound management is represented by topical treatments, such as antibacterial or colloidal agents, in order to prevent infection and promote a proper wound-healing process. Nanotechnology studies submicroscopic particles (maximum diameter of 100 nm), as well as correlated phenomena. Metal nanoparticles (e.g., silver, gold, zinc) are increasingly being used in dermatology, due to their beneficial effect on accelerating wound healing, as well as treating and preventing bacterial infections. Other benefits include: ease of use, less frequent dressing changes and a constantly moist wound environment. This review highlights recent findings regarding nanoparticle application in wound management.

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Section: Nanomaterials In Wound Healingmentioning

confidence: 99%

Nanomaterials for Wound Healing and Infection Control

et al. 2019

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“…The combination of ZnO NPs with a chitosan hydrogel demonstrates optimal antibacterial activity with low toxicity and renders the composite an ideal material for wound dressing [63]. In this respect, Balaure et al [81] reported that the wound dressing consisting of collagen with ZnO NPs and 1% orange essential oil demonstrates accelerated wound closure and also inhibits bacterial growth with excellent biocompatibility both in vitro and in vivo. Likewise, the work by Gao et al [82] confirmed the wound-healing ability of ZnO NPs as an antimicrobial tissue adhesive with an in vivo study using a skin wound mouse model.…”

Section: Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

2020

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Nanomaterial-based wound healing has tremendous potential for treating and preventing wound infections with its multiple benefits compared with traditional treatment approaches. In this regard, the physiochemical properties of nanomaterials enable researchers to conduct extensive studies on wound-healing applications. Nonetheless, issues concerning the use of nanomaterials in accelerating the efficacy of existing medical treatments remain unresolved. The present review highlights novel approaches focusing on the recent innovative strategies for wound healing and infection controls based on nanomaterials, including nanoparticles, nanocomposites, and scaffolds, which are elucidated in detail. In addition, the efficacy of nanomaterials as carriers for therapeutic agents associated with wound-healing applications has been addressed. Finally, nanomaterial-based scaffolds and their premise for future studies have been described. We believe that the in-depth analytical review, future insights, and potential challenges described herein will provide researchers an up-to-date reference on the use of nanomedicine and its innovative approaches that can enhance wound-healing applications.

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“…Having this in mind, Balaure et al [227] recently developed a collagen dressing containing orange essential oil functionalized ZnO nanoparticles ( d = 20 nm) inserted into a three-dimensional (3D) matrix. As was described above, ZnO nanoparticles present antimicrobial activity, and their incorporation into collagen to impart biocidal properties is a strategy that has also been followed by other authors [228,229].…”

Section: Proteins/polypeptidesmentioning

confidence: 99%

Bio-Based Polymers with Antimicrobial Properties towards Sustainable Development

et al. 2019

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This article concisely reviews the most recent contributions to the development of sustainable bio-based polymers with antimicrobial properties. This is because some of the main problems that humanity faces, nowadays and in the future, are climate change and bacterial multi-resistance. Therefore, scientists are trying to provide solutions to these problems. In an attempt to organize these antimicrobial sustainable materials, we have classified them into the main families; i.e., polysaccharides, proteins/polypeptides, polyesters, and polyurethanes. The review then summarizes the most recent antimicrobial aspects of these sustainable materials with antimicrobial performance considering their main potential applications in the biomedical field and in the food industry. Furthermore, their use in other fields, such as water purification and coating technology, is also described. Finally, some concluding remarks will point out the promise of this theme.

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In vitro and in vivo studies of novel fabricated bioactive dressings based on collagen and zinc oxide 3D scaffolds

Cited by 75 publications

References 20 publications

Nanomaterials for Wound Healing and Infection Control

Nanomaterials for Wound Healing and Infection Control

Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

Bio-Based Polymers with Antimicrobial Properties towards Sustainable Development

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