Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

Naskar, Atanu; Kim, Kwang-sun

doi:10.3390/pharmaceutics12060499

Cited by 158 publications

(126 citation statements)

References 120 publications

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“…Among biodegradable and natural-based polymers [4], sodium alginate fibers have applications in preparation of wound care dressings [23,24]. Combination of alginate with AgNPs could result in an enhancement in healing properties while broadening the antimicrobial spectrum of wound dresses [25,26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Farjadian

Akbarizadeh

Tayebi

2020

Heliyon

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In this study, a new type of silver nanoparticles capped with metronidazolium based ionic liquid is synthesized. By this aim, metronidazole is altered to ionic-liquid type structure with citrate counter ion as reducing agent. The produced reducing agent was characterized using 1 HNMR and 13 CNMR and FT-IR. The capability of metronidazolium-based reducing agent in formation and capping silver nanoparticles was examined in a chemical reaction. More specifically, synthesized silver nanoparticles were synthesized and capped with metronidazoliumcitrate based ionic liquid, while the formation of particles in 48 h was monitored by UV-Vis spectroscopy. Fourier transform infrared spectroscopy showed the presence of capping agents around silver nanoparticles. The amount of metronidazolium and citrate as capping agents was determined by thermal gravimetric analysis. The prepared crystalline structure of silver nanoparticles was proved by X-ray diffraction spectroscopy. PSA analysis and TEM was performed to determine the size of particles. The synthesized silver nanoparticle has the potential to be used as an antibacterial agent in preparation of wound dressing with extra capability and efficacy in aerobic and anaerobic bacterium. In this regard, the antibacterial efficacy of discs from different concentration of silver nanoparticles in calcium alginate medium were evaluated in Gram-negative and Gram-positive bacterium.

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Section: Introductionmentioning

confidence: 99%

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Farjadian

Akbarizadeh

Tayebi

2020

Heliyon

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“…Currently, metallic nanoparticles such as zinc, copper, silver, and gold are being studied not only for their antibacterial activity, but also for their different potential biomedical applications [ 12 , 13 , 57 , 58 , 59 , 60 ]. The extensive use of these nanoparticles can be attributed to their large surface area along with their positive charge, which can interact with negatively charged bacterial cell surfaces [ 11 ].…”

Section: Bacteriocin–nanomaterials Combinationmentioning

confidence: 99%

Potential Novel Food-Related and Biomedical Applications of Nanomaterials Combined with Bacteriocins

Naskar

Kim

2021

Pharmaceutics

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Bacteriocins are antimicrobial peptides or proteinaceous materials produced by bacteria against pathogens. These molecules have high efficiency and specificity and are equipped with many properties useful in food-related applications, such as food preservatives and additives, as well as biomedical applications, such as serving as alternatives to current antibacterial, antiviral, anticancer, and antibiofilm agents. Despite their advantages as alternative therapeutics over existing strategies, several limitations of bacteriocins, such as the high cost of isolation and purification, narrow spectrum of activity, low stability and solubility, and easy enzymatic degradation, need to be improved. Nanomaterials are promising agents in many biological applications. They are widely used in the conjugation or decoration of bacteriocins to augment the activity of bacteriocins or reduce problems related to their use in biomedical applications. Therefore, bacteriocins combined with nanomaterials have emerged as promising molecules that can be used in various biomedical applications. This review highlights the features of bacteriocins and their limitations in biomedical applications and provides a detailed overview of the uses of different nanomaterials in improving the limitations. Our review focuses on the potential applications of nanomaterials combined with bacteriocins as new designer molecules for use in future therapeutic strategies.

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“…[7,[95][96][97] Polymeric nanoparticles Most studies remain at the laboratory research stage; Toxicity, side effects, long-term efficacy, and in vivo metabolic mechanism still need to be further studied; Critical design is necessary for its safe application. [86][87][88]98,103] Silica Nanoparticles [9,22,93,94] Copper oxide NPs treatment resulted in massive formation of macrophages, fibroblasts and collagen fibers and higher degree of new blood capillary formation in comparison with the control. [61]…”

Section: Copper Oxide Nanoparticlesmentioning

confidence: 99%

Nanomaterials in wound healing: From material sciences to wound healing applications

et al. 2020

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An increasing number of innovative therapies have emerged in the field of wound healing. Nanostructured systems have been used to improve wound healing at different stages. The drug itself may be formulated at a nanoscale such that it can function as its own "carrier" or nanomaterials may be used as drug delivery vehicles. The present work covers the latest advancements on innovative nano-based organic and inorganic materials. These novel drug delivery systems possess high stability, large surface area and tunable compositions and have demonstrated their wound-healing properties using in vitro and in vivo models. Key areas in the development of new systems for wound care are the assessment of biological compatibility, the evaluation of anti-microbial activity and the in vivo efficacy assessment using full-thickness skin models. Due to the multifactorial nature of chronic wound occurrence robust models should support the investigation of new materials in order to elucidate mechanisms involved in the sequence of physiologic processes that take place at wound healing. Although several nanoparticles have been successfully tested both in vitro and in vivo, researchers are still investigating the approaches to implementing large scale production of nanotechnological platforms to wound healing treatments.

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Recent Advances in Nanomaterial-Based Wound-Healing Therapeutics

Cited by 158 publications

References 120 publications

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Potential Novel Food-Related and Biomedical Applications of Nanomaterials Combined with Bacteriocins

Nanomaterials in wound healing: From material sciences to wound healing applications

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