In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptis fasciculata

Silva, C.G.; Raulino, R.J.; Cerqueira, Débora M.; Mannarino, Sérgio C.; Pereira, Marcos D.; Panek, Anita D.; Silva, J.F.M.; Menezes, Fábio S.; Eleuthério, Elis C. A.

doi:10.1016/j.phymed.2008.12.019

Cited by 51 publications

(37 citation statements)

References 32 publications

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“…Similarly, H. fasciculata and IQ, which was identified in this species, showed activity as 1,1diphenyl2picrylhydrazyl (DPPH) radical scavengers, suggesting their antioxidant potential in human cancer [84] . Flavonoids are also foreign compounds (xenobiotics), which can potentially modulate the activity of cytochrome P450s (CYPs), the xenobioticmetabolizing enzymes involved in the activation and detoxification of food and environmental carcinogens.…”

Section: Liver Cancermentioning

confidence: 81%

Review of anticancer mechanisms of isoquercitin

Orfali¹,

Duarte²,

Bonadio³

et al. 2016

WJCO

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This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.

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Section: Liver Cancermentioning

confidence: 81%

Review of anticancer mechanisms of isoquercitin

Orfali¹,

Duarte²,

Bonadio³

et al. 2016

WJCO

View full text Add to dashboard Cite

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“…More interestingly, flavonoids with the 3′,4′-dihydroxy group (i.e., quercetin and quercitrin) demonstrated the highest inhibitory activity against AGEs formation after incubation at 37°C for 14 days, with IC50 values much lower than that of AG [111]. Besides quercetin, the flavonoid glycosides isoquercitrin (quercetin-3-β-glucopyranoside) and hyperin (quercetin-3-D-galactoside) are well-known antioxidants [116][117][118]. Isoquercitrin showed outstanding antioxidant activity in yeast cells by increasing the activity of superoxide dismutase (SOD) [118].…”

Section: Flavones Flavonols Flavanones and Flavanonolesmentioning

confidence: 99%

“…Besides quercetin, the flavonoid glycosides isoquercitrin (quercetin-3-β-glucopyranoside) and hyperin (quercetin-3-D-galactoside) are well-known antioxidants [116][117][118]. Isoquercitrin showed outstanding antioxidant activity in yeast cells by increasing the activity of superoxide dismutase (SOD) [118]. It also demonstrated free radical scavenging properties [119].…”

Section: Flavones Flavonols Flavanones and Flavanonolesmentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…This experiment was carried out by the method of Steels et al (1994), Pereira et al (2003) and Silva et al (2009). The S. cerevisiae wild type strain BY4741 (MATa;his3;leu2;met15;ura3) used in the in vivo antioxidant assays was acquired from Euroscarf, Frankfurt, Germany.…”

Section: In Vivo Antioxidant Analysismentioning

confidence: 99%

Evaluation of antimicrobial, antioxidant and phototoxic activities of extracts and isolated compounds from Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae

Souza¹,

Silva²,

Machado³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Avalição da atividade antimicrobiana, antioxidante e fototóxica dos extratos e compostos isolados de Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae". Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, é uma planta utilizada na medicina popular brasileira contra úlceras e lesões de pele. Internamente é usada contra inflamações, febre, doenças renais e aterosclerose. Essa planta foi estudada com o objetivo de identificar os compostos bioativos majoritários que possam justificar seu uso terapêutico contra lesões de pele e arteriosclerose. A atividade antioxidante do extrato bruto etanólico, partições e os compostos majoritários isolados das raízes de S. cayennesis foi avaliada através de testes in vivo e in vitro. In vitro a atividade antioxidante foi avaliada pelo teste fotocolorimétrico do radical 2,2-difenil-1-picrilidrazil (DPPH•). In vivo, Saccharomyces cerevisiae, um modelo de célula eucariótica, foi utilizado tanto para avaliar a fototoxicidade quanto a capacidade antioxidante contra as espécies reativas de oxigênio (EROS) menadiona e peróxido de hidrogênio. O extrato, partições e os dois compostos majoritários isolados, verbascosídeo e ácido betulínico foram capazes de aumentar a sobrevivência e diminuir a peroxidação lipídica de S. cerevisiae contra EROS. Verbascosídeo apresentou atividade antimicrobiana moderada contra Streptococcus pyogenes, S.epidermidis e Staphylococcus aureus. O extrato etanólico e as partições testadas não apresentaram fototoxicidade, indicando que S. cayennensis é uma planta segura para o tratamento de lesões de pele e como possível ingrediente em cosméticos.Unitermos: Stachytarpheta cayennensis, antioxidante, antimicrobial, fototoxicidade, arilpropanoide glicosilado, ácido betulínico.ABSTRACT: Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, plant extract, is a Brazilian medicinal plant externally used in folk medicine for purulent ulcers, skin lesions and internally for inflammations, fever, renal disorders and atherosclerosis. S. cayennesis was studied to identify potential bioactive compounds that may justify their therapeutic use against skin lesions and atherosclerosis. The antioxidant, antimicrobial and phototoxicity capacities of the crude ethanolic extract, fractions and isolated compounds from roots of S. cayennesis were evaluated through in vivo and in vitro tests. Strains of Saccharomyces cerevisiae, an eukaryotic cell model, were used to assess both the phototoxicity and the capacity to protect against the lethal oxidative stress caused by menadione and hydrogen peroxide. The extract, fractions and the two major isolated compounds, verbascoside and betulinic acid, of S. cayennensis were able to increase the tolerance and decrease the lipid peroxidation of S. cerevisiae to reactive oxygen species (ROS). The antioxidant activity was also evaluated by scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•). Verbascoside exhibited a moderate antimicrobial activity against Streptococcus pyogenes, S.epidermidis and Staphylococcus aureus. Neither the ethanol...

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In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptis fasciculata

Cited by 51 publications

References 32 publications

Review of anticancer mechanisms of isoquercitin

Review of anticancer mechanisms of isoquercitin

Plant-Derived Agents with Anti-Glycation Activity

Evaluation of antimicrobial, antioxidant and phototoxic activities of extracts and isolated compounds from Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae

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