In vitro and in vivo release of diclofenac sodium-loaded sodium alginate/carboxymethyl chitosan-ZnO hydrogel beads

Niu, Baolong; Jia, Jianhong; Wang, Heping; Chen, Siyu; Cao, Wenling; Yan, Jianghao; Gong, Xuechen; Lian, Xiaojie; Li, Wenfeng; Fan, Yanying

doi:10.1016/j.ijbiomac.2019.09.059

Cited by 34 publications

(12 citation statements)

References 34 publications

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“…The burst release might be attributed to the swift dissolution of free and non-entrapped tilmicosin in the TIL-SLNs. For the TIL-nanogel, the release mechanism of hydrogels was illustrated clearly in previous research [47,48]. Firstly, water entered hydrogel matrix, the hydrogel swelled and the TIL-loaded carnauba wax SLNs started to be corroded.…”

Section: Resultsmentioning

confidence: 82%

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Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel

Zhou

Wang²,

Chen

et al. 2019

Pharmaceutics

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The Staphylococcus aureus (S. aureus) cow mastitis causes great losses to the cow industry. In order to improve the treatment effect of tilmicosin against cow mastitis, the combination of solid lipid nanoparticle (SLN) technology with in situ hydrogel technology was used to prepare the self-assembly tilmicosin nanogel (TIL-nanogel). The physicochemical characteristics, in vitro release, antibacterial activity and in vivo treatment efficacy of TIL-SLNs and TIL-nanogel were studied, respectively. The results showed the loading capacity (LC), encapsulation efficiency (EE), size, zeta potential and poly dispersion index (PDI) of TIL-nanogel were 23.33 ± 0.77%, 67.89 ± 3.01%, 431.57 ± 12.87 nm, 8.3 ± 0.06 mv and, 0.424 ± 0.032, respectively. The TIL-nanogel showed stronger sustained release in vitro than TIL-SLNs and commercial injection. The cure rate of half dosage and normal dosage of TIL-nanogel was 58.3% and 75.0%, which was higher than that of commercial injection (50.0%) at normal dosage. The results suggest that the treatment dosage of tilmicosin for cow mastitis could be reduced by TIL-nanogel. The novel TIL-nanogel will be beneficial by decreasing the usage of tilmicosin and the treatment costs of cow mastitis.

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Section: Resultsmentioning

confidence: 82%

“…Then tilmicosin was diffused from the TIL-SLNs and crossed the swelling hydrogel. The release rate of the TIL-nanogel depended on the swelling rate of the hydrogel matrix and the erosion rate of the carnauba wax [45,47]. Due to the swelling limitation of the hydrogel matrix, the TIL-nanogel showed a slower release rate than the TIL-SLNs.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel

Zhou

Wang²,

Chen

et al. 2019

Pharmaceutics

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“…Alginate hydrogels fortified with other biopolymers may find practical application as colon-targeted devices. Sodium alginate/carboxymethyl chitosan–ZnO hydrogel beads have been proposed by Niu et al as an effective and safe system to deliver diclofenac sodium, a nonsteroidal, anti-inflammatory drug, which is sensitive to gastrointestinal environmental effects and could also cause stomach irritation [ 22 ]. Braim et al designed colon-targeted, pH-triggered lactoferrin-loaded microparticles, effective in protection against C. difficile toxin-mediated human intestinal epithelial damage [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

et al. 2021

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This study aimed to characterize the hydrogel micro- and macro-particles designed to deliver curcumin to human colon cancer cells (LoVo). Six series of vehicles based on sodium alginate (micro- and macro-particles, uncoated, coated with chitosan or gelatin) were synthesized. The uncoated microparticles were fabricated using an emulsion-based technique and the uncoated macroparticles with an extrusion technique, with both coupled with ionotropic gelation. The surface morphology of the particles was examined with scanning electron microscopy and the average size was measured. The encapsulation efficiency, moisture content, and swelling index were calculated. The release of curcumin from the particles was studied in an experiment simulating the conditions of the stomach, intestine, and colon. To evaluate the anticancer properties of such targeted drug delivery systems, the cytotoxicity of both curcumin-loaded and unloaded carriers to human colon cancer cells was assessed. The microparticles encapsulated much less of the payload than the macroparticles and released their content in a more prolonged manner. The unloaded carriers were not cytotoxic to LoVo cells, while the curcumin-loaded vehicles impaired their viability—more significantly after incubation with microparticles compared to macroparticles. Gelatin-coated or uncoated microparticles were the most promising carriers but their potential anticancer activity requires further thorough investigation.

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“…Se encapsuló diclofenaco sódico utilizando como materiales de recubrimientos alginato de sodio (SA), óxido de zinc (ZnO NPs) y carboximetil quitosano (CMCS), dando como resultado una matriz mixta SA/CMCS-ZnO (0.1 g/g) con una eficiencia de encapsulación de 82.32 y una carga de diclofenaco sódico de 7.56 %. El fármaco presentó una liberación lenta, esto se atribuyó al aumento de la densidad de reticulación, lo cual se demostró por las pruebas in vitro [40].…”

Section: Alginato De Sodiounclassified

Avances en las investigaciones sobre la encapsulación mediante gelación iónica: una revisión sistemática

Ortiz-Romero

Ochoa-Martínez

González‐Herrera

et al. 2021

TecnoL.

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La encapsulación es una tecnología que proporciona barreras entre los compuestos de interés en un producto y el medio ambiente. Ella brinda una mejor estabilidad fisicoquímica durante el procesamiento y/o almacenamiento del producto, por lo tanto, ayuda a tener una menor degradación de los compuestos de interés, enmascara olores y sabores indeseables, controla la liberación del principio activo y puede incrementar su bioaccesibilidad y su biodisponibilidad. El objetivo de esta revisión fue recopilar y discutir la literatura reciente enfocada en investigaciones científicas sobre la encapsulación mediante gelación iónica de compuestos bioactivos, de microorganismos, de enzimas y su uso en diferentes aplicaciones de interés científico y/o industrial. La revisión bibliográfica se realizó en las principales bases de datos indexadas, utilizando descriptores como tamaño de cápsula, eficiencia de encapsulación, matrices mixtas, alginato de sodio y gelación iónica. De acuerdo con los resultados se observó que la utilización de este tipo de encapsulación presenta ventajas muy variables que se centran en la mejora de diversos factores como la biodisponibilidad de compuestos bioactivos, estabilidad de diferentes compuestos, características físicas, liberación del compuesto de interés y la protección contra efectos ambientales adversos. En conclusión, existe una amplia gama de aplicaciones que puede tener la metodología de gelación iónica para encapsular ingredientes alimenticios, microorganismos y fármacos, entre otros. Finalmente, el estudio pretende que esta revisión sea de utilidad en la dirección de investigaciones sobre gelación iónica, debido a la diversidad de aplicaciones abordadas durante la investigación.

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In vitro and in vivo release of diclofenac sodium-loaded sodium alginate/carboxymethyl chitosan-ZnO hydrogel beads

Cited by 34 publications

References 34 publications

Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel

Enhanced Treatment Effects of Tilmicosin Against Staphylococcus aureus Cow Mastitis by Self-Assembly Sodium Alginate-Chitosan Nanogel

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

Avances en las investigaciones sobre la encapsulación mediante gelación iónica: una revisión sistemática

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