In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts

A Retroinhibition Approach Reveals a Tumor Cell–Autonomous Response to Rapamycin in Head and Neck Cancer

“…Two million control or lentiviral-infected HN12 and CAL27 cells were used to induce HNSCC tumor xenografts, and tumor growth analysis was performed as described (30). Drug treatment was initiated when tumor volume reached f100 to 150 mm 3 (31). For each experiment, tumor-bearing animals were randomly divided into two groups of 20 animals and injected i.p.…”

Breaking through a roadblock in prostate cancer research: An update on human model systems

“…Retrospective studies in other solid tumours have shown that there is a better prediction of clinical outcome when xenograft lines are used as a pre-clinical model [70,73]. Furthermore, primary tumour xenografts have resulted in translation of drugs into the clinic, such as HER2-postive breast tumour xenografts to study a panel of murine antibodies, which resulted in the humanisation of the drug Trastuzumab [70,74].…”

Mutational Analysis of the PTEN Gene and Its Effects in Esophageal Squamous Cell Carcinoma

“…The animals were monitored for tumor inspection every other day. Drug treatment was not initiated until the tumor volume reached 55-80 mm 3 [14][15][16]. The schedule of drug treatment was a single injection (i.p.)…”