In Vitro and In Silico Characterization of Curcumin-Loaded Chitosan–PVA Hydrogels: Antimicrobial and Potential Wound Healing Activity

Chopra, Hitesh; Bibi, Shabana; Mohanta, Yugal Kishore; Mohanta, Tapan Kumar; Kumar, Sandeep; Singh, Inderbir; Khan, Muhammad Saad; Rauta, Pradipta Ranjan; Alshammari, Abdulrahman; Alharbi, Metab; Alasmari, Abdullah F.

doi:10.3390/gels9050394

Cited by 14 publications

(4 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using curcumin in hydrogel dressings instead of various nanoparticles (e.g., Cu, Ag) reduces the potential toxicity while maintaining the antimicrobial effect towards Gram-positive and Gram-negative bacteria. Other advantages of these materials include antioxidant properties, hemostatic effect, and enhanced collagen formation, which results in faster and better wound healing, including infected ones, which was confirmed in the in vitro and in vivo studies [46,47,[54][55][56][57].…”

Section: Wound Healingmentioning

confidence: 64%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

View full text Add to dashboard Cite

Curcumin is a natural compound with a great pharmaceutical potential that involves anticancer, anti-inflammatory, antioxidant, and neuroprotective activity. Unfortunately, its low bioavailability, instability, and poor water solubility significantly deteriorate its clinical use. Many attempts have been made to overcome this issue, and encapsulating curcumin in a hydrogel matrix may improve those properties. Hydrogel formulation is used in many drug delivery forms, including classic types and novel forms such as self-assembly systems or responsive to external factors. Reviewed studies confirmed better properties of hydrogel-stabilized curcumin in comparison to pure compound. The main enhanced characteristics were chemical stability, bioavailability, and water solubility, which enabled these systems to be tested for various diseases. These formulations were evaluated for wound healing properties, effectiveness in treating skin diseases, and anticancer and regenerative activity. Hydrogel formulation significantly improved biopharmaceutical properties, opening the opportunity to finally see curcumin as a clinically approved substance and unravel its therapeutic potential.

show abstract

Section: Wound Healingmentioning

confidence: 64%

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Stachowiak,

Mlynarczyk,

Dlugaszewska

2024

Molecules

View full text Add to dashboard Cite

show abstract

“…It is worth emphasizing that chitosan has been loaded with other active substances, for example, honey [ 53 ], curcumin [ 54 , 55 ], plant essential oil [ 56 ], and many other compounds [ 8 , 57 ]. Chitosan-based membranes and nanoparticles can be used in drug delivery, per-oral delivery, pulmonary drug delivery, nasal drug delivery, mucosal drug delivery, gene delivery, buccal drug delivery, vaccine delivery, vaginal drug delivery, and cancer therapy [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Chitosan-Based Films Containing Rutin for Potential Cosmetic Applications

Sionkowska,

Lewandowska,

Kurzawa

2023

Polymers

View full text Add to dashboard Cite

Chitosan is a polysaccharide with film-forming properties. Such properties are widely used for the preparation of beauty masks and wound-healing materials. In this work, chitosan-based films containing hyaluronic acid and rutin have been researched for potential cosmetic applications. Rutin was added to a chitosan solution in lactic acid, and then thin films were fabricated. The structure of the films was studied using FTIR spectroscopy. Surface properties were studied using an AFM microscope. The release of rutin from chitosan-based film was researched by the HPLC method. The properties of the skin, such as elasticity and moisturization, were studied using the Aramo TS 2 apparatus. It was found that the addition of rutin did not have an influence on the chitosan structure but affected its thermal stability. The roughness of the films was bigger after the addition of rutin to chitosan-based films. Skin elasticity and skin moisturization were somewhat improved after the topical application of the proposed chitosan–rutin mask. The maximum release of rutin was found after 20 min at pH 5.5, related to the pH of normal human skin. The average percentage of release from chitosan-based film containing hyaluronic acid was smaller than from chitosan-based films.

show abstract

“…Synthetic PVA hydrogels have also been tested by loading them with Calendula officinalis extract, which improves the adhesiveness and was effective against both Gram-positive and Gram-negative bacteria [ 103 ]. Curcumin, obtained from the roots of Curcuma longa, is a hydrophobic polyphenolic compound with remarkable bioactive properties, and promising results have been obtained by loading it into chitosan or PVA hydrogels [ 104 , 105 , 106 , 107 ]. Some essential oils are derived from plants such as lavender, thyme, peppermint, tea tree, rosemary, cinnamon, eucalyptus, and lemongrass [ 108 ].…”

Section: Classification Of Antimicrobial Hydrogelsmentioning

confidence: 99%

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Ortega,

De Leon-Oliva,

Boaru

et al. 2023

Gels

View full text Add to dashboard Cite

The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense, antimicrobial hydrogels represent a promising opportunity with multiple translational expectations in the medical management of infectious diseases due to their unique physicochemical and biological properties as well as for drug delivery in specific areas. Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. Moreover, antimicrobial hydrogels (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, and antimicrobial properties. In the present review, we collect and discuss the most promising strategies in the development of AMH, which are divided into hydrogels with inherent antimicrobial activity and antimicrobial agent-loaded hydrogels based on their composition. Then, we present an overview of the main translational applications: wound healing, tissue engineering and regeneration, drug delivery systems, contact lenses, 3D printing, biosensing, and water purification.

show abstract

In Vitro and In Silico Characterization of Curcumin-Loaded Chitosan–PVA Hydrogels: Antimicrobial and Potential Wound Healing Activity

Cited by 14 publications

References 60 publications

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Wondrous Yellow Molecule: Are Hydrogels a Successful Strategy to Overcome the Limitations of Curcumin?

Chitosan-Based Films Containing Rutin for Potential Cosmetic Applications

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Contact Info

Product

Resources

About