In-vitro and animal studies of the potassium ion depletion filter.

頌一, 稲葉; 憲昭, 白濱; 武史, 湯浅; 貴昭, 大重; 道夫, 安部

doi:10.3925/jjtc1958.42.218

Cited by 5 publications

(8 citation statements)

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“…Our previous animal study showed no toxicity of the preservation solution used for storage of this filter 23 . The vital signs in dogs showed no adverse reactions to autologous blood passed through this filter 23 . This study found no changes in vital signs after filtration with the tested filter, except fever, which was also found in the control group.…”

Section: Discussionsupporting

confidence: 45%

“…Third, adverse reactions to this filter were investigated. Our previous animal study showed no toxicity of the preservation solution used for storage of this filter 23 . The vital signs in dogs showed no adverse reactions to autologous blood passed through this filter 23 .…”

Section: Discussionmentioning

confidence: 73%

“…100 mEq/L), the increase in Na + level is preferable because it approximates the physiologic level. Second, we were interested in RBC function after passage through the tested filter, and we previously reported preliminary findings 22,23 . RBC, Hb, and Hct recovery exceeded 95 percent, and the 2,3 DPG, ATP, and morphology scores were unchanged after passage through this filter.…”

Section: Discussionmentioning

confidence: 98%

“…This filter resin adsorbs K + and releases Na + in equivalent amounts. We have finished prototype testing of the K + ‐depletion filter for K + ‐adsorption capacity and the influence on RBCs passed through the filter, a toxicity test of eluates from the filter using rats, and an animal trial of autologous transfusion of long‐preserved, irradiated, K + ‐added RBCs in dogs 23 . We report here the results of a Phase III trial of a K + ‐adsorption filter (7R‐001, Kawasumi Laboratories, Tokyo, Japan).…”

mentioning

confidence: 99%

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Potassium‐adsorption filter for RBC transfusion: a Phase III clinical trial

Inaba

Nibu²,

Takano³

et al. 2000

Transfusion

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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Potassium‐adsorption filter for RBC transfusion: a Phase III clinical trial

Inaba

Nibu²,

Takano³

et al. 2000

Transfusion

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“…As described above, SPS is a cation‐exchange resin that efficiently binds cations in exchange for Na + . Unexpectedly, however, an in vitro study found no significant changes in Mg 2+ , Ca 2+ , pH, or Cl – when RBC units were filtered through this filter at blood flow rates of 25 and 200 mL/min . Furthermore, after stored AP‐3 RBCs were filtered through the filter, the Mg 2+ concentration increased, but the Ca 2+ concentration was consistently <0.54 mmol/L (below the measurable level) and the pH was constantly <6.4 (below the reference range) .…”

mentioning

confidence: 96%

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Suzuki¹,

Muto

Miyata

et al. 2015

Ther Apher Dial

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A K(+) -adsorption filter was developed to exchange K(+) in the supernatant of stored irradiated red blood cells with Na(+) . To date, however, the filter's adsorption capacity for K(+) has not been fully evaluated. Therefore, we characterized the cation-binding capacity of this filter. Artificial solutions containing various cations were continuously passed through the filter in 30 mL of sodium polystyrene sulfonate at 10 mL/min using an infusion pump at room temperature. The cation concentrations were measured before and during filtration. When a single solution containing K(+) , Li(+) , H(+) , Mg(2+) , Ca(2+) , or Al(3+) was continuously passed through the filter, the filter adsorbed K(+) and the other cations in exchange for Na(+) in direct proportion to the valence number. The order of affinity for cation adsorption to the filter was Ca(2+) >Mg(2+) >K(+) >H(+) >Li(+) . In K(+) -saturated conditions, the filter also adsorbed Na(+) . After complete adsorption of these cations on the filter, their concentration in the effluent increased in a sigmoidal manner over time. Cations that were bound to the filter were released if a second cation was passed through the filter, despite the different affinities of the two cations. The ability of the filter to bind cations, especially K(+) , should be helpful when it is used for red blood cell transfusion at the bedside. The filter may also be useful to gain a better understanding of the pharmacological properties of sodium polystyrene sulfonate.

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