Reduction in potassium concentration of stored red blood cell units using a resin filter

Yamada, Chisa; Heitmiller, Eugenie S.; Ness, Paul M.; King, Karen E.

doi:10.1111/j.1537-2995.2010.02742.x

Cited by 31 publications

(33 citation statements)

References 17 publications

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“…Furthermore, the use of potassium absorption filters during transfusion may also decrease potassium loading[12,13]. Moreover, factors that also play a role in the increase of potassium levels are the rate and volume of transfusion as well as the patient’s circulating pre-transfusion blood volume.…”

Section: Discussionmentioning

confidence: 99%

Severe hyperkalemia following blood transfusions: Is there a link?

Rizos

Milionis

Elisaf

2017

WJN

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Patients with gastrointestinal bleeding often require large volume blood transfusion. Among the various side effects of blood transfusion, the increase of potassium levels is a serious one which is often overlooked. We report a case of severe hyperkalemia in a patient with gastric bleeding after large volume transfusion of packed red blood cells. The patient had hyperkalemia at baseline associated with his receiving medication as well as acute renal failure following hypovolemia. The baseline hyperkalemia was further aggravated after massive transfusions of packed red blood cells in a short period of time. The associated pathogenetic mechanisms resulting in the increase of potassium levels are presented. A number of risk factors which increase the risk of hyperkalemia after blood transfusion are discussed. Moreover, appropriate management strategies for the prevention of blood transfusion associated hyperkalemia are also presented. Physicians should always keep in mind the possibility of hyperkalemia in cases of blood transfusion.

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Section: Discussionmentioning

confidence: 99%

Severe hyperkalemia following blood transfusions: Is there a link?

Rizos

Milionis

Elisaf

2017

WJN

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“…HD patients and neonates have a higher risk of hyperkalemia. A potassium adsorption filter (PAF; KPF-4, Kawasumi Laboratories, Inc., Tokyo, Japan) was developed and approved for use in Japan [33]. Made with sodium polystyrene sulfonate resin, it exchanges potassium with sodium.…”

Section: Upnmentioning

confidence: 99%

Autologous blood transfusion for hemodialysis patients: A case report and review of clinical reports and therapeutic features

Suzuki

Okai

Ohashi

et al. 2015

Transfusion and Apheresis Science

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“…Similarly, Yamada et al. reported that the filter decreased the K + concentration in RBCs stored in additive solution (AS)‐3 to minimal levels in the first and second RBC units, but not in the third RBC unit, when three AP‐3 RBC units were filtered by a single filter under gravity. Taken together, these results highlight the potential for using this filter in bedside settings to reduce the K + concentration in stored RBC units.…”

mentioning

confidence: 93%

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Suzuki¹,

Muto

Miyata

et al. 2015

Ther Apher Dial

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A K(+) -adsorption filter was developed to exchange K(+) in the supernatant of stored irradiated red blood cells with Na(+) . To date, however, the filter's adsorption capacity for K(+) has not been fully evaluated. Therefore, we characterized the cation-binding capacity of this filter. Artificial solutions containing various cations were continuously passed through the filter in 30 mL of sodium polystyrene sulfonate at 10 mL/min using an infusion pump at room temperature. The cation concentrations were measured before and during filtration. When a single solution containing K(+) , Li(+) , H(+) , Mg(2+) , Ca(2+) , or Al(3+) was continuously passed through the filter, the filter adsorbed K(+) and the other cations in exchange for Na(+) in direct proportion to the valence number. The order of affinity for cation adsorption to the filter was Ca(2+) >Mg(2+) >K(+) >H(+) >Li(+) . In K(+) -saturated conditions, the filter also adsorbed Na(+) . After complete adsorption of these cations on the filter, their concentration in the effluent increased in a sigmoidal manner over time. Cations that were bound to the filter were released if a second cation was passed through the filter, despite the different affinities of the two cations. The ability of the filter to bind cations, especially K(+) , should be helpful when it is used for red blood cell transfusion at the bedside. The filter may also be useful to gain a better understanding of the pharmacological properties of sodium polystyrene sulfonate.

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Reduction in potassium concentration of stored red blood cell units using a resin filter

Cited by 31 publications

References 17 publications

Severe hyperkalemia following blood transfusions: Is there a link?

Severe hyperkalemia following blood transfusions: Is there a link?

Autologous blood transfusion for hemodialysis patients: A case report and review of clinical reports and therapeutic features

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

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