In Vitro Analysis: The Antimicrobial and Antioxidant Activity of Zinc Oxide Nanoparticles From Curcuma Longa

Jacob, Vinoy; Periakaruppan, Rajiv

doi:10.22159/ajpcr.2019.v12i1.28808

Cited by 22 publications

(5 citation statements)

References 30 publications

(31 reference statements)

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“…Gallic acid was taken as a standard material and showed IC 50 value of 16.65 µg mL −1 (R 2 = 0.587). This antioxidant activity against DPPH • is better or at least comparable to that (~70%) previously reported for Curcuma longa-mediated ZnO particles with the same concentration [61].…”

Section: Dpph Scavenging Assaysupporting

confidence: 87%

“…Analysis of the inhibition percentages revealed IC 50 values of 55.26 µg mL −1 (R 2 = 0.792) and 20.87 µg mL −1 (R 2 = 0.825) for ZnO@OFE NPs and gallic acid, respectively. An antioxidant efficacy of 81% was achieved for 200 µg mL −1 of ZnO@OFE NPs, which outperforms that previously reported (~70%) for Curcuma longa-assisted ZnO NPs using the same concentration [61].…”

Section: Hydrogen Peroxide Scavenging Assaycontrasting

confidence: 61%

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Improved Photocatalytic and Antioxidant Activity of Olive Fruit Extract-Mediated ZnO Nanoparticles

Ghaffar,

Abbas,

Naeem-ul-Hassan

et al. 2023

Antioxidants

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Photodegradation is an efficient strategy for the removal of organic pollutants from wastewater. Due to their distinct properties and extensive applications, semiconductor nanoparticles have emerged as promising photocatalysts. In this work, olive (Olea Europeae) fruit extract-based zinc oxide nanoparticles (ZnO@OFE NPs) were successfully biosynthesized using a one-pot sustainable method. The prepared ZnO NPs were systematically characterized using UV-Vis, FTIR, SEM, EDX and XRD and their photocatalytic and antioxidant activity was evaluated. SEM demonstrated the formation of spheroidal nanostructures (57 nm) of ZnO@OFE and the EDX analysis confirmed its composition. FTIR suggested the modification/capping of the NPs with functional groups of phytochemicals from the extract. The sharp XRD reflections revealed the crystalline nature of the pure ZnO NPs with the most stable hexagonal wurtzite phase. The photocatalytic activity of the synthesized catalysts was evaluated by measuring the degradation of methylene blue (MB) and methyl orange (MO) dyes under sunlight irradiation. Improved degradation efficiencies of 75% and 87% were achieved within only 180 min with photodegradation rate constant k of 0.008 and 0.013 min−1 for MB and MO, respectively. The mechanism of degradation was proposed. Additionally, ZnO@OFE NPs exhibited potent antioxidant activity against DPPH, hydroxyl, peroxide and superoxide radicals. Hence, ZnO@OFE NPs may have potential as a cost-effective and green photocatalyst for wastewater treatment.

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Section: Dpph Scavenging Assaysupporting

confidence: 87%

Section: Hydrogen Peroxide Scavenging Assaycontrasting

confidence: 61%

Improved Photocatalytic and Antioxidant Activity of Olive Fruit Extract-Mediated ZnO Nanoparticles

Ghaffar,

Abbas,

Naeem-ul-Hassan

et al. 2023

Antioxidants

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“…The broad particle size distribution is mostly due to particle size aggregation, which is mainly related to the electrostatic attraction of zinc oxide nanoparticles [ 48 ]. It was reported that the biosynthesised zinc oxide nanoparticles from Curcuma longa rhizomes exhibited a spherical shape with a diameter of 25 nm [ 49 ]. Another study synthesised zinc oxide nanoparticles using casein as a capping agent and conjugated curcumin on their surfaces with a diameter of 12.8 nm and a zeta potential of −23.9 mV, and the particles remained stable in the solution [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to Stan et al [ 54 ], the scavenging activity of zinc oxide nanoparticles is size-dependent, where the smallest size displayed the highest antiradical activity [ 54 ]. Zinc oxide nanoparticles using Curcuma longa rhizomes exhibited good antiradical activity, almost 70% at 200 µg/mL [ 49 ]. The antioxidant activity of curcumin-ZnO NPs demonstrates moderate activity by scavenging 70% at 2 mg/mL [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

Alallam

Doolaanea²,

Alfatama

et al. 2023

Pharmaceuticals

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Zinc oxide and curcumin, on their own and in combination, have the potential as alternatives to conventional anticancer drugs. In this work, zinc oxide nanoparticles (ZnO NPs) were prepared by an eco-friendly method using pure curcumin, and their physicochemical properties were characterised. ATR-FTIR spectra confirmed the role of curcumin in synthesising zinc oxide curcumin nanoparticles (Green-ZnO-NPs). These nanoparticles exhibited a hexagonal wurtzite structure with a size and zeta potential of 27.61 ± 5.18 nm and −16.90 ± 0.26 mV, respectively. Green-ZnO-NPs showed good activity towards studied bacterial strains, including Escherichia coli, Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. The minimum inhibitory concentration of Green-ZnO-NPs was consistently larger than that of chemically synthesised ZnO NPs (Std-ZnO-NPs) or mere curcumin, advocating an additive effect between the zinc oxide and curcumin. Green-ZnO-NPs demonstrated an efficient inhibitory effect towards MCF-7 cells with IC50 (20.53 ± 5.12 μg/mL) that was significantly lower compared to that of Std-ZnO-NPs (27.08 ± 0.91 μg/mL) after 48 h of treatment. When Green-ZnO-NPs were tested against Artemia larvae, a minimised cytotoxic effect was observed, with LC50 being almost three times lower compared to that of Std-ZnO-NPs (11.96 ± 1.89 μg/mL and 34.60 ± 9.45 μg/mL, respectively). This demonstrates that Green-ZnO-NPs can be a potent, additively enhanced combination delivery/therapeutic agent with the potential for anticancer therapy.

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“…38 The antioxidant property of ZnO-NPs could be resulted from the transfer of electron density located at oxygen to the odd electron located at nitrogen atom in DPPH. 39 This characteristic is dependent on the structural configuration of oxygen atom, and it determines the thermal stability of nanoparticle. 40 In addition, the antioxidant efficacy of ZnO-NPs against DPPH is likely due to the electrostatic attraction between positively charged NPs (ZnO = Zn 2+ + O 2 ) of plant extracts and negatively charged bioactive compounds (COO -, O -).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Zinc Oxide Nanoparticles on Drought Stress in Moringa peregrina Populations

Foroutan

Solouki

Abdossi

et al. 2019

Int J Basic Sci Med

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Introduction: Moringa peregrina (Forssk.) Fiori, is a nutritionally and medicinally important desert tree, which is constantly exposed to drought stress. This study was accomplished to alleviate the adverse effects of drought stress on M. peregrina populations through the foliar application of zinc oxide nanoparticles (ZnO-NPs) by monitoring some physiological and biochemical alterations. Methods: Moringa peregrina seeds were collected from the Southeast of Iran in 2014. Fourteen days after germination, the seedlings were subjected to drought stress by withholding watering until 50% field capacity (FC), followed by spraying 0.1% and 0.05% ZnO-NPs and no spraying (as control). Results: The changes of sodium (Na), potassium (K), chlorophylls, total phenolic content (TPC) as well as antioxidant activity under drought stress condition varied based on M. peregrina populations. Drought stress significantly reduced chlorophylls content, while it enhanced TPC and antioxidant activity. ZnO-NPs treatment significantly inhibited chlorophylls degradation under drought stress conditions. It also enhanced chlorophyll content in well-watered plants. Moreover, it was revealed that TPC and antioxidant activity of M. peregrina populations significantly increased in response to foliar application of ZnO-NPs in both drought-stressed and unstressed plants. Conclusion: Our results suggested that ZnO-NPs spray can augment drought tolerance of different populations of M. peregrina subjected to water deficit condition.

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In Vitro Analysis: The Antimicrobial and Antioxidant Activity of Zinc Oxide Nanoparticles From Curcuma Longa

Cited by 22 publications

References 30 publications

Improved Photocatalytic and Antioxidant Activity of Olive Fruit Extract-Mediated ZnO Nanoparticles

Improved Photocatalytic and Antioxidant Activity of Olive Fruit Extract-Mediated ZnO Nanoparticles

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

The Effects of Zinc Oxide Nanoparticles on Drought Stress in Moringa peregrina Populations

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