In Vitro Analyses of Diamond-like Carbon Coated Stents

Gutensohn, K.; Beythien, C.; Bau, J.; Fenner, Terrence W.; Grewe, Peter; Koester, Ralf; Padmanaban, K.; Kuehnl, P.

doi:10.1016/s0049-3848(00)00295-4

Cited by 257 publications

(57 citation statements)

References 40 publications

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“…For example, diamondlike carbon has been considered for use in a coronary artery stents, synthetic heart valves, left ventricular assist devices, and artificial hearts, because platelet activation and platelet adhesion occur less often on diamondlike carbon-coated surfaces than on conventional (titanium, titanium carbide, titanium nitride, or stainless steel) surfaces [31][32][33][34][35][36][37][38]. Another medical application for diamondlike carbon thin films is use on hip joint prostheses and knee joint prostheses.…”

Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

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Implants containing antimicrobial metals may reduce morbidity, mortality, and healthcare costs associated with medical device-related infections. We have deposited diamondlike carbonsilver (DLC-Ag), diamondlike carbon-platinum (DLC-Pt), and diamondlike carbon-silverplatinum (DLC-AgPt) thin films using a multicomponent target pulsed laser deposition process.Transmission electron microscopy of the DLC-silver and DLC-platinum composite films revealed that the silver and platinum self-assemble into nanoparticle arrays within the diamondlike carbon matrix. The diamondlike carbon-silver film possesses hardness and Young's modulus values of 37 GPa and 331 GPa, respectively. The diamondlike carbon-metal composite films exhibited passive behavior at open-circuit potentials. Low corrosion rates were observed during testing in a phosphate-buffered saline (PBS) electrolyte. In addition, the diamondlike carbon-metal composite films were found to be immune to localized corrosion below 1000 mV (SCE). DLC-silver-platinum films demonstrated exceptional antimicrobial properties against Staphylococcus bacteria. It is believed that a galvanic couple forms between platinum and silver, which accelerates silver ion release and provides more robust antimicrobial activity.Diamondlike carbon-silver-platinum films may provide unique biological functionalities and improved lifetimes for cardiovascular, orthopaedic, biosensor, and implantable microelectromechanical systems.

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Section: Wsrc-ms-2005-00051mentioning

confidence: 99%

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Morrison

Buchanan

Liaw

et al. 2006

Diamond and Related Materials

134

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“…Moreover, these coatings are biocompatible and chemically inert and thus interesting for biomedical applications, namely hip joints [4], knee replacements [5] coronary artery stents [6] or heart valves [7]. DLC coatings consist on hydrogenated and non hydrogenated amorphous carbon (a-C:H and a-C, respectively) with different structures according to their chemical composition.…”

Section: Introductionmentioning

confidence: 99%

Influence of Ag content on mechanical and tribological behavior of DLC coatings

Manninen

Ribeiro

Escudeiro

et al. 2013

Surface and Coatings Technology

101

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Ag-DLC coatings with Ag contents ranging from 1.3 at.% to 13.1 at.% were deposited by DC magnetron sputtering. The coatings were characterized with respect to their structure (by means of XRD and Raman Spectroscopy), mechanical and tribological properties (by scratch test, nanoindentation, residual stress measurements and pin-on-disk test). The incorporation of 13.1 at.% Ag resulted in the formation of Ag grains with 2-3 nm which promoted the increase of graphite like bonds organized in rings. Regarding the mechanical properties, no variations were found for films with Ag contents lower than 13 at.%; a reduction of both hardness and compressive residual stress were then observed for higher values. Pin-on-disk tests were performed at two different contact pressures (690 MPa and 1180 MPa) in dry sliding conditions against a zirconia counterpart. For the lower contact pressure the variations in the wear rate are well correlated with the coatings structure and mechanical properties, while for higher contact pressure the presence of Ag is relevant, Ag-DLC coatings showing higher wear rate than DLC one. SEM analysis revealed the formation of Ag aggregates on the wear track and adhesion of silver to the counterpart.

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“…[1][2][3][4][5][6] The feasibility of amorphous carbon coatings was investigated for a variety of applications like surgical needles, [2] orthopaedic implants and prostheses, [7][8][9][10][11] medical guidewires, [12][13][14][15] coronary artery stents [16,17] and also for mechanical heart valve replacement and other solid implants. [18][19][20][21][22][23] The functionality, performance and durability of artificial surfaces in vivo are determined and often limited by their interaction with blood or tissue.…”

mentioning

confidence: 99%

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

Stüber¹,

Niederberger²,

Danneil³

et al. 2007

Adv Eng Mater

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Diamond-like carbon (DLC) and amorphous carbon (a-C, a-C:H) coatings, respectively, have been proposed since many years as potential materials for biomedical applications due to their chemical inertness, low friction coefficient, high wear resistance, bio-and haemocompatibility. [1][2][3][4][5][6] The feasibility of amorphous carbon coatings was investigated for a variety of applications like surgical needles, [2] orthopaedic implants and prostheses, [7][8][9][10][11] medical guidewires, [12][13][14][15] coronary artery stents [16,17] and also for mechanical heart valve replacement and other solid implants. [18][19][20][21][22][23] The functionality, performance and durability of artificial surfaces in vivo are determined and often limited by their interaction with blood or tissue. However, the coagulation mechanism of blood on amorphous carbon (DLC) films in such a biomedical environment is not understood in detail even if the biocompatibility of DLC coatings was described early by many reports. [1,3,[24][25][26] Extensive information on individual aspects, like protein adsorption, platelet adhesion and activation on carbonaceous surfaces has been accumulated in the literature. [27][28][29] Since a few years more sophisticated approaches to the scientific understanding of the complex interaction of blood and inorganic surfaces are emerging by addressing this field through fundamental and interdisciplinary research efforts offering synoptical views based on materials science, chemistry, biology, physics, physical chemistry and medicine. [30][31][32] Main factors have been recognised to influence significantly the cell adhesion and interaction on amorphous carbon: these include the constitution of the carbon films and the fraction of the sp 3 bonds, [12,30] the surface energy and hydrophobicity, [27] and the surface roughness and topography. [26,31] The properties of a-C and DLC coatings, especially the biofunctional ones, can further be modified by incorporating other elements in the coatings, such as H, N, F, P, Si and metals. [4,5,[33][34][35][36][37][38][39] It is well known that the incorporation of additional elements into an amorphous carbon matrix has a very strong impact on the surface energy and wettability of such coatings. [40][41][42] Combining various surface modification methods should thus offer new tools for a future engineering design of biofunctional thin film materials, covering a wide range of properties, for example from strongly hydrophilic to extremely hydrophobic. Recently, it was shown that the modification of the inherent surface topography of carbon films on the nano-scale by proper adjusting of the deposition process and kinetics can strongly impact the wetting behaviour. [43] Similar or complementary effects were achieved through creating an artificial micro-or nano-scale surface topography by laser-patterning or plasma-etching or by subsequent thermal processing of carbon coatings. [44][45][46] From the biological perspective, the competitive adsorption of several plasma proteins (al...

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In Vitro Analyses of Diamond-like Carbon Coated Stents

Cited by 257 publications

References 40 publications

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Electrochemical and antimicrobial properties of diamondlike carbon-metal composite films

Influence of Ag content on mechanical and tribological behavior of DLC coatings

Surface Topography, Surface Energy and Wettability of Magnetron‐Sputtered Amorphous Carbon (a‐C) Films and Their Relevance for Platelet Adhesion

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