In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive
            <i>Aspergillus terreus</i>
            Infection

Steinbach, William J.; Perfect, John R.; Schell, Wiley A.; Walsh, Thomas J.; Benjamin, Daniel K.

doi:10.1128/aac.48.9.3217-3225.2004

Cited by 89 publications

(60 citation statements)

References 99 publications

(38 reference statements)

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“…Our study also confirmed earlier observations of the resistance of A. terreus to AMB (24,29). A. terreus is reported in a wide range of immunocompromised patients.…”

Section: Resultssupporting

confidence: 81%

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

et al. 2009

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We analyzed antifungal susceptibilities of 274 clinical Aspergillus isolates from transplant recipients with proven or probable invasive aspergillosis collected as part of the Transplant-Associated Infection Surveillance Network (TRANSNET) and examined the relationship between MIC and mortality at 6 or 12 weeks. Antifungal susceptibility testing was performed by the Clinical and Laboratory Standards Institute (CLSI) M38-A2 broth dilution method for amphotericin B (AMB), itraconazole (ITR), voriconazole (VOR), posaconazole (POS), and ravuconazole (RAV). The isolate collection included 181Aspergillus fumigatus, 28 Aspergillus niger, 27 Aspergillus flavus, 22 Aspergillus terreus, seven Aspergillus versicolor, five Aspergillus calidoustus, and two Aspergillus nidulans isolates and two isolates identified as Aspergillus spp. Triazole susceptibilities were <4 g/ml for most isolates (POS, 97.6%; ITR, 96.3%; VOR, 95.9%; RAV, 93.5%). The triazoles were not active against the five A. calidoustus isolates, for which MICs were >4 g/ml. AMB inhibited 93.3% of isolates at an MIC of <1 g/ml. The exception was A. terreus, for which 15 (68%) of 22 isolates had MICs of >1 g/ml. One of 181 isolates of A. fumigatus showed resistance (MIC > 4 g/ml) to two of three azoles tested. Although there appeared to be a correlation of higher VOR MICs with increased mortality at 6 weeks, the relationship was not statistically significant (R 2 ‫؍‬ 0.61; P ‫؍‬ 0.065). Significant relationships of in vitro MIC to all-cause mortality at 6 and 12 weeks for VOR or AMB were not found.

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“…Our study also confirmed earlier observations of the resistance of A. terreus to AMB (24,29). A. terreus is reported in a wide range of immunocompromised patients.…”

Section: Resultssupporting

confidence: 81%

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

et al. 2009

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“…The AMB MICs for isolates of Aspergillus section Terrei are commonly high, and the outcome of patients treated with VRC is better than that of patients treated with a polyene (7,29,30). The Infectious Diseases Society of America guidelines recommend the use of VRC instead AMB for the treatment of infections caused by A. terreus (31).…”

Section: Discussionmentioning

confidence: 99%

Aspergilluscitrinoterreus, a New Species of Section Terrei Isolated from Samples of Patients with Nonhematological Predisposing Conditions

et al. 2015

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eThe use of molecular identification techniques has revealed an increasing number of new species within Aspergillus section Terrei. We phenotyped a set of 26 clinical isolates that showed genetic differences from Aspergillus terreus sensu stricto by analyzing sequences from PCR-amplified ␤-tubulin and calmodulin genes and the internal transcribed spacer region. Since the isolates were phylogenetically and morphologically different from all of the members of Aspergillus section Terrei, they are described here as a new species, Aspergillus citrinoterreus, so named because it produces a diffusible yellowish pigment in agar. A. citrinoterreus isolates were significantly more susceptible to itraconazole, voriconazole, and posaconazole than A. terreus sensu stricto isolates were; in contrast, the amphotericin B MICs for both species were high. A. citrinoterreus was found in clinical samples from patients with proven or probable invasive aspergillosis and colonized patients, none of whom had hematological malignancies as predisposing conditions. However, they did have other underlying conditions such as chronic obstructive pulmonary disease, cirrhosis, and cancer or had received a solid organ transplants and presented not only with invasive pulmonary aspergillosis but also with mediastinitis. A. citrinoterreus isolates were detected for the first time in 2002. In all cases of invasive aspergillosis, A. citrinoterreus was found to be a copathogen, mostly with A. fumigatus. Invasive aspergillosis affects patients with hematological and nonhematological conditions such as chronic obstructive pulmonary disease (COPD) (1-3). Most cases of invasive aspergillosis are caused by Aspergillus fumigatus and A. flavus. A. terreus is the third most common cause of invasive aspergillosis and a particularly prevalent microorganism in some geographic areas (4-8).Molecular tools can provide an accurate picture of the epidemiology of invasive aspergillosis and have revealed the presence of cryptic Aspergillus species frequently missed by conventional techniques (9-11). The number of newly described species within the section Terrei has grown during the last few years and includes A. alabamensis, A. allahabadii, A. ambiguous, A. aureoterreus, A. carneus, A. floccosus, A. hortai, A. microcysticus, A. neoafricanus, A. neoindicus, A. niveus, A. pseudoterreus, and A. terreus sensu stricto (12). To date, most of these species, with the exception of A. terreus sensu stricto, have not been reported to cause invasive aspergillosis in humans.We previously used molecular techniques to identify a set of Aspergillus section Terrei isolates collected from clinical samples from patients admitted to a general teaching hospital (13). Most of the isolates were identified as A. terreus sensu stricto, but a clade of isolates showed some remarkable genetic differences. The isolates comprising the clade have been phenotypically characterized and are reported here as representatives of a proposed new species within Aspergillus section Terrei, namely, Asperg...

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“…However, there are a lot studies in which the pollution with mycotoxin mainly Aspergillus has been treat e.g. [77] [78].…”

Section: Discussionmentioning

confidence: 99%

Screening of Bacterial and Fungal Biota Associated with Oreochromis niloticus in Lake Manzala and Its Impact on Human Health

Zaky¹,

Ibrahim²

2017

Health

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In this study fish samples were investigated for Bacteria and Fungi, in fish parts, such as intestine, gills and skin. Bacterial counts of Total viable bacteria (T.V.B) reached more than 9.5 × 10 5 cfu and faecal coliforms (F.C) reached 1.2 × 10 5 cfu. Different species were identified, Using API technology. Escherichia coli comes first by being recording thirty number case of isolation constituting 36%, it followed by Proteus mirabilis which is represented by twenty four number case of isolation accounting for 30%. Other taxa viz: Klebsiella pneumonia, Citrobacter freundii, Providencia stuartii and Erwinia sp. came next according to their case number of isolation, they represented only by 7%. They showed different antibiotics with different inhibitory concentrations, resistance pattern to gentamycin 10 μg, Penicillin G, tetracycline 30 μg, Ampicillin 10 μg, Ampicillin 30 μg, chloramphenicol (C) 30 μg, Rifampicin 25 μg, Streptomycin 5 μg, cefotaxime 15 μg. Mycological investigation revealed the presence of variety of fungal species, particularly, toxigenic species, such as, Aspergillus spp, Penicillium spp and Fusarium spp. These results are indication of the spoilage of fishes which caught from Lake Manzala and are risky for human consumption and hazardous to human health in this important area of Egypt, due to the high pollution condition of Lake Manzala.

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In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection

Cited by 89 publications

References 99 publications

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

Aspergilluscitrinoterreus, a New Species of Section Terrei Isolated from Samples of Patients with Nonhematological Predisposing Conditions

Screening of Bacterial and Fungal Biota Associated with Oreochromis niloticus in Lake Manzala and Its Impact on Human Health

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