In vitro &amp; in vivo assessment of a herbal formula used topically for bone fracture treatment

Peng, Li‐Hua; Ko, Chun‐Hay; Siu, Sum Wing; Koon, Chi Man; Yue, Gar Lee; Cheng, Wai Hing; Lau, David Tai-Wai; Han, Quan‐Bin; Ng, Ka Ming; Fung, Kwok‐Pui; Lau, Clara Bik San; Leung, Ping Chung

doi:10.1016/j.jep.2010.06.039

Cited by 59 publications

(48 citation statements)

References 28 publications

(23 reference statements)

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“…The three herbs selected for this pilot study had also been proven anti-inflammatory, pro-angiogenic and cellular proliferation in the laboratory [6]. The results of the pilot study using the herbal patch on the undisplaced fractures of the fifth metatarsal bone were very encouraging: the control of tissue swelling and pain relief in 2 -4 weeks' time were very good; the maintenance of ADL and mobilities of the foot and ankle were also good as were shown in the FAAM and AOFAS scores.…”

Section: Discussionmentioning

confidence: 99%

“…In our earlier studies, the three herbs had been shown in the laboratory to be anti-inflammatory, proangiogenic and promoting cellular proliferations. These biological effects were all essential for bone and tissue repair [6]- [8]. The herbs in 1:1:1 proportions were steamed to provide a condensed concoction, freeze-drying of which gave a fine powder preparation, ready to be reconstituted into a paste for topical use in the form of a sticky patch.…”

Section: Medicinal Herbs Used In a Novel Topical Agent For Injury Trementioning

confidence: 99%

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Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

Tse¹,

Cheng²,

Tso³

et al. 2015

OJTR

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To observe the safety and effectiveness of a topical herbal agent used to promote fracture healing, a herbal patch containing extracts of three herbs, viz., Flos Carthami, Radix Dipsaci, Rhizoma Rhei and Borneolum Syntheticum (an enhancer) was applied on ten subjects with un-displaced fifth metatarsal fractures. Pain scores, foot and ankle function questionnaires and regional swelling were carefully assessed and recorded. Peripheral blood was taken to measure the inflammation cytokines. Assessment checks were performed biweekly to enforce effective patch application and compliance. The results showed that pain improved after two weeks and fracture sites swelling had 20% reduction in thickness when measured with an ultrasonic tool. Foot and ankle functional scores markedly improved after six weeks. Radiological examinations revealed early perfect fracture unions. The topical herbal patch was effective in promoting fracture healing. It was well tolerated by the fracture patients. Larger randomized controlled trials would be indicated.

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Section: Discussionmentioning

confidence: 99%

Section: Medicinal Herbs Used In a Novel Topical Agent For Injury Trementioning

confidence: 99%

Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

Tse¹,

Cheng²,

Tso³

et al. 2015

OJTR

View full text Add to dashboard Cite

show abstract

“…In-vitro and in-vivo experiments will be required to illustrate the essential biological activities of the individual herbs and their combination [17] .…”

Section: What Are the Biological Activities That The Topical Herbs Gementioning

confidence: 99%

“…In-vivo experiments included zebra fish embryo studies to verify the pro-angiogenic effects of the herbs and animal models on soft tissues injury and bone fractures, where a topical paste was applied to promote healing. Using radiological, biochemical and biomechanical (on the long bone after fracture healing) testings, the topical paste was demonstrated to have promoted the fracture callus formation, increased bone-specific alkaline phosphatase level and stronger fracture union [17,21] . In-vivo experiments on the healing of soft tissues after injury under the influence of the herbal paste are still going on.…”

Section: What Are the Biological Activities That The Topical Herbs Gementioning

confidence: 99%

How does Traditional Medicine Supplement Current Orthopaedic Practice and Rehabilitation?

Leung

2016

International Journal of Orthopaedics

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Orthopaedic practice has gained impressive advancements in the past decades and the most important achievements have been made after the two world wars, when the need for injury and fracture treatment was urgent and vast.Orthopaedic experts of today, might not realize that "Bone setting" used to be the main service provided to skeletal injuries and fractures. "Bone setters" have their special techniques and therapeutic agents (mostly topical) to ensure satisfactory results. They also provide various techniques for the control of pain and to facilitate recovering, i.e. rehabilitation.Although the old traditional techniques have been replaced by modern hospital practice, they remain popular outside the hospital and specialist clinics because patients are in favour of additional treatment measures so that pain is better controlled, and healing and recovery could be quicker.This review selected three important areas of Traditional Medicine that should contribute towards modern Orthopaedic Practice and discusses about the scientific evaluations being done to give evidence to those practices. It will be appropriate for the orthopaedic experts to get acquainted with the apparently unscientific traditional practices and consider making use of them under appropriate situations.

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“…As a typical compound of DAW, the protective effect of Akebia saponin D (ASD) (Fig. 1) has been described in some disease models such as cancer (8), Alzheimer's disease (7,9), cardiovascular disease (2,10,11), and bone fractures (12,13). Our previous studies have shown that ASD has a hepatoprotective effect in a mouse model (14).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction

Gong

Wang

2014

J Pharmacol Sci

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Abstract. Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore the molecular mechanism of the hepatoprotective effects of ASD on BRL cells and isolated rat liver mitochondria. We investigated the effects of ASD on rotenone-induced toxicity in BRL cells. The results showed that ASD inhibited the accumulation of reactive oxidant species, ATP deficiency, and mitochondrial membrane potential dissipation; ameliorates mitochondrial respiratory dysfunction, and improved the activity of complex I in a concentration-dependent manner, indicating that ASD likely improved mitochondrial function. ASD suppressed rotenone-induced BRL cell apoptosis and increased Bcl-2/Bax ratio. These results suggest that ASD may exert hepatoprotective effects against rotenone-induced toxicity through mitochondria. This study supports our previous research that ASD possesses hepatoprotective activity in vivo and it is worthy of further study.

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In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment

Cited by 59 publications

References 28 publications

Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

How does Traditional Medicine Supplement Current Orthopaedic Practice and Rehabilitation?

Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction

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