Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

Tse, Lung-fung; Cheng, Hi-Shan; Tso, Chi-Yin; Hung, Yuk-Wah; Hung, L.K.; Chen, Jingzhou; Zhou, Xue-lin; Fung, Chak‐Hei; Pang, Elizabeth; Cheng, King-Fai; Wong, Chun-Kwok; Leung, Ping‐Chung

doi:10.4236/ojtr.2015.32005

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…The topical treatment for all three sites had been very well accepted by patients. Recurrences after cessation of local treatment were observed in some cases, but the intensities were apparently much less than before treatment ( Tse et al, 2015a , b ).…”

Section: Research On Topical Agentsmentioning

confidence: 99%

Selected Topical Agents Used in Traditional Chinese Medicine in the Treatment of Minor Injuries- A Review

Leung

Siu

et al. 2016

Front. Pharmacol.

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Topical medicinal patches have been popular for the treatment of minor injuries like sprains and avulsions. Other inflammatory conditions like chronic musculo-tendinous pain and or fasciitis are also taken care of by local ointments or rubs. In the oriental communities, medicinal herbs frequently form the major components of the patches. In spite of the lack of scientific evidence of efficacy, the popularity of such traditional application persists for centuries. In this era of evidence-based clinical treatment, there is an urgent need to look into this traditional practice. The purpose should include a scientific verification of the efficacy of the practice, and once proven, further explorations would be indicated to bring the practice to a higher level. A system of comprehensive exploration was proposed and practiced in the past years to fulfill the aspiration. The research consisted of four areas:(1) Identification of the suitable medicinal herbs for the topical study;(2) Study of the biological activities of the selected herbs, concentrating on the areas of anti-inflammation, anti-oxidation, angiogenesis and cellular proliferation;(3) Study on the transcutaneous transport of the chemicals of the selected herbs to deeper tissues; and(4) Pilot clinical studies on common superficial inflammatory musculo-skeletal conditions to give objective clinical evidences to the topical applications.Five herbs were identified as suitable candidates of study. They were put into relevant laboratory platforms and were proven to be anti-oxidant, anti-inflammatory and pro-angiogenic. Three of the herbs were prepared as topical patches with an enhancer and used to treat three common ailments in pilot clinical trials, viz., plantar fasciitis, undisplaced metatarsal fracture and tendonitis of the wrist (de-Quervain’s disease) and the elbow (Tennis elbow). The clinical results of the pilot studies were very positive. It is therefore concluded that further explorations are justified to create medicinal herb patches of even greater efficacy.

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Section: Research On Topical Agentsmentioning

confidence: 99%

Selected Topical Agents Used in Traditional Chinese Medicine in the Treatment of Minor Injuries- A Review

Leung

Siu

et al. 2016

Front. Pharmacol.

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“…The amalgamation of the three carefully selected herbs resulted in an herbal paste aptly named CDR, derived from the abbreviation of their respective names. Clinical trials have demonstrated the efficacy of topically applying CDR for the treatment of conditions such as fifth metatarsal fractures and plantar fasciitis [ 23 , 24 ]. Furthermore, our research group has shown that when used in conjunction with oral pharmaceutical agents, CDR exhibits an additive effect, facilitating the healing process of fractures [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine for Topical Treatment of Skeletal Muscle Injury

Siu,

Ma,

Cheng

et al. 2023

Pharmaceuticals

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Muscle injuries are common musculoskeletal problems, but the pharmaceutical agent for muscle repair and healing is insufficient. Traditional Chinese Medicine (TCM) frequently uses topical treatments to treat muscle injuries, although scientific evidence supporting their efficacy is scarce. In this study, an in vitro assay was used to test the cytotoxicity of a topical TCM formula containing Carthami Flos, Dipsaci Radix, and Rhei Rhizoma (CDR). Then, a muscle contusion rat model was developed to investigate the in vivo effect and basic mechanisms underlying CDR on muscle regeneration. The in vitro assay illustrated that CDR was non-cytotoxic to immortalized rat myoblast culture and increased cell viability. Histological results demonstrated that the CDR treatment facilitated muscle repair by increasing the number of new muscle fibers and promoting muscle integrity. The CDR treatment also upregulated the expression of Pax7, MyoD and myogenin, as evidenced by an immunohistochemical study. A gene expression analysis indicated that the CDR treatment accelerated the regeneration and remodeling phases during muscle repair. This study demonstrated that topical CDR treatment was effective at facilitating muscle injury repair.

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“…The CDNR was then further optimized to a 3-herb formula: CDR (Notoginseng Rhizoma was excluded). A clinical trial on the efficacy of the CDR herbal paste in the treatment of the fifth metatarsal fracture has been conducted recently [ 28 ]. The results showed that the pain was soothed after two weeks of treatment.…”

Section: Introductionmentioning

confidence: 99%

Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate

Siu

Shiu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Strontium ranelate (SrR) is one of the pharmaceutical agents reported to be effective on the promotion of fracture healing. This study aimed to evaluate the integrative effect of the oral SrR with a topical Chinese herbal paste, namely, CDR, on facilitation of bone healing. The in vivo efficacy was evaluated using rats with tibial fracture. They were treated with either CDR topically, or SrR orally, or their combined treatments. The in vivo results illustrated a significant additive effect of CDR on SrR in increasing the yield load of the fractured tibia. The in vitro results showed that neither SrR nor CDR exhibited a cytotoxic effect on UMR106 and bone-marrow stem cell (BMSC), but both of them increased the proliferation of BMSC at low concentrations. The combination of CDR at 200 μg/mL with SrR at 200 or 400 μg/ml also showed an additive effect on increasing the ALP activity of BMSC. Both SrR and CDR alone reduced osteoclast formation, and the effective concentration of SrR to inhibit osteoclastogenesis was reduced in the presence of CDR. This integrative approach by combining oral SrR and topical CDR is effective in promoting fracture healing properly due to their additive effects on proosteogenic and antiosteoclastogenic properties.

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Does Topical Agent Help Fracture Healing? A Pilot Study Using a Herbal Patch

Cited by 3 publications

References 8 publications

Selected Topical Agents Used in Traditional Chinese Medicine in the Treatment of Minor Injuries- A Review

Selected Topical Agents Used in Traditional Chinese Medicine in the Treatment of Minor Injuries- A Review

Traditional Chinese Medicine for Topical Treatment of Skeletal Muscle Injury

Integrative Approach to Facilitate Fracture Healing: Topical Chinese Herbal Paste with Oral Strontium Ranelate

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