In vitro adsorption of mebeverine hydrochloride onto kaolin and its relationship to pharmacological effects of the drug in vivo

Gohary, O. M. N. Al

doi:10.1016/s0031-6865(96)00042-8

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…Many types of adsorbents such as kaolin [8,9], charcoal [10], polymers [11] attapuligate [12] and bentonite [13][14][15][16][17] in adsorption of drug, are recognized in clinical practice and environmental treatment. The safety, high adsorptive capacity, there low density and the high specific surface, have been accepted for a long time, and they account for most of the current uses of clay.…”

Section: Introductionmentioning

confidence: 99%

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Adsorption of Ciprofloxacin Hydrochloride from Aqueous Solution by Iraqi Porcelinaite Adsorbent

Al-Heetimi¹,

Kadhum²,

Al-Khazrajy³

2012

JNUS

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Pharmaceuticals are widely distributed in different applications and also released into the environment. Adsorption of Ciprofloxacin HCl (CIPH) on Porcelinaite was studied at ambient conditions. The adsorption isotherms can be well described using the Freundlich and Temkin equations. The pH of the solution influences significantly the adsorption capacity of Porcelinaite, the adsorption of CIPH increased from the initial pH 1.3 and then decreased over the pH rang of 3.8-9. The adsorption is sensitive to the change in ionic Strength, which indicate that electrostatic attraction is a significant mechanism for sorption process. The enthalpy change (∆H) for the adsorption of CIPH onto Porcelinaite signifies an endothermic adsorption. The ∆G value is negative at all studied temperatures, inferring that, the adsorption of CIPH onto porcelinaite will follow a spontaneous trend. The ∆G value decreased when the temperature increased from 15 o C to 37.5 o C, suggesting increase in adsorption of CIPH with increasing temperature. The positive value of ∆S reflects the affinity of porcelinaite towards drug and also suggests increased randomness at the solid-solution interface.

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Section: Introductionmentioning

confidence: 99%

“…Gibb's free energy change ∆G is calculated using K0. The equilibrium constant Kocan be defined as: ................................ (8).…”

mentioning

confidence: 99%

Adsorption of Ciprofloxacin Hydrochloride from Aqueous Solution by Iraqi Porcelinaite Adsorbent

Al-Heetimi¹,

Kadhum²,

Al-Khazrajy³

2012

JNUS

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“…Например, в состав ядра таблеток мексиприма вхо-дит нерастворимый в воде наполнитель -каолин, который может снижать биодоступность действую-щего вещества за счет его физической адсорбции или ионного обмена [10].…”

Section: Discussionunclassified

A comparative study of mexidol and mexiprim pharmacokinetic parameters

Shchulkin¹,

Yakusheva²,

Chernykh³

2014

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…The extent of adsorption may increase, decrease, or remain unchanged as a result of changing the pH. Many variables can take part in this process such as the nature of chemical state of the adsorbent, adsorbate and solvent [17]. The results in Table (4) indicate that the adsorption capacity in acidic medium increases with increasing and reach a maximum at pH value of 7.3.…”

Section: Effect Of Phmentioning

confidence: 99%

Adsorption of Congo Red Dye from Aqueous Solution onto Natural and Modified Bauxite Clays

Journal¹

2017

Baghdad Sci.J

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The adsorption behavior of congo red dye from its aqueous solutions was investigated onto natural and modified bauxite clays. Both bauxite and modified bauxite are primarily characterized by using, FTIR, SEM, AFM, and XRD. Several variables are studied as a function of adsorption including contact time, adsorbent weight, pH, ionic strength, particle size and temperature under batch adsorption technique. The absorbance of the solution before and after adsorption was measured spectrophotometrically. The equilibrium data fit with Langmuir model of adsorption and the linear regression coefficient R2 is found to be 0.9832 and 0.9630 for natural and modified bauxite respectively at 37.5°C which elucidate the best fitting isotherm model. The general shape of the adsorption isotherm of congo red on natural and modified bauxite is consistent with (H-type) on the Giles classification. Different thermodynamic parameters such as Gibb's free energy, enthalpy and entropy of the on-going adsorption process have also been evaluated. The thermodynamic analyses of the congo red adsorption on natural and modified bauxite indicate that the systems are endothermic in nature

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In vitro adsorption of mebeverine hydrochloride onto kaolin and its relationship to pharmacological effects of the drug in vivo

Cited by 12 publications

References 25 publications

Adsorption of Ciprofloxacin Hydrochloride from Aqueous Solution by Iraqi Porcelinaite Adsorbent

Adsorption of Ciprofloxacin Hydrochloride from Aqueous Solution by Iraqi Porcelinaite Adsorbent

A comparative study of mexidol and mexiprim pharmacokinetic parameters

Adsorption of Congo Red Dye from Aqueous Solution onto Natural and Modified Bauxite Clays

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