In Vitro Activity of Vancomycin, Teicoplanin, Linezolid and Daptomycin Against Methicillin-Resistant Staphylococcus aureus Isolates Collected from Chinese Hospitals in 2018–2020

Abstract

Introduction Vancomycin, teicoplanin, linezolid and daptomycin are four major antibacterials used for methicillin-resistant Staphylococcus aureus (MRSA) infection treatment. However, with the increasing failure of clinical MRSA anti-infective treatment, it is urgent to investigate the status of MRSA sensitivity to these four drugs. Methods In the present study, 407 non-duplicated MRSA isolates from 6 provinces in China were collected from January 2018 to August 2020. The minimum inhibitory concentrations (MICs) of vancomycin, teicoplanin, linezolid and daptomycin were determined by broth microdilution method, and their MIC50, MIC90, and geometric mean MIC were calculated. Results All 407 MRSA strains were sensitive to these four antibacterials. MIC range of vancomycin, teicoplanin, linezolid and daptomycin was 0.25 to 2 mg/L, 0.125 to 4 mg/L, 0.25 to 4 mg/L and 0.06 to 1 mg/L, respectively. Between 2018 and 2020, there was no “MIC creep” in vancomycin, teicoplanin and daptomycin. The geometric mean MIC of linezolid was not increased, but both MIC50 and MIC90 in 2019 and 2020 MRSA isolates were higher than 2018 isolates. Conclusion All MRSA isolates remained sensitivity to vancomycin, teicoplanin, linezolid and daptomycin. The linezolid MIC50 and MIC90 increased have been found in this study.

Antibiotics Susceptibility Profile of <i>Staphylococcus aureus</i> Clinical Isolates Collected in Hospitals in the City of Douala (Cameroon)

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Investigating the Antibacterial Effects of Synthetic Gamma-Lactam Heterocycles on Methicillin-Resistant Staphylococcus aureus Strains and Assessing the Safety and Effectiveness of Lead Compound MFM514

“…MRSA continues to be one of the main causes of hospital-acquired infections in all regions of the world [ 1 , 2 ]. This difficult and economically relevant pathogen have been known to display multidrug-resistance (MDR) properties towards a wide range of structurally unrelated antibiotics and antimicrobial agents [ 1 , 2 ].…”

“…MRSA continues to be one of the main causes of hospital-acquired infections in all regions of the world [ 1 , 2 ]. This difficult and economically relevant pathogen have been known to display multidrug-resistance (MDR) properties towards a wide range of structurally unrelated antibiotics and antimicrobial agents [ 1 , 2 ]. In 2017, MRSA was inducted as a Priority 2: high-level bacteria in the first-ever WHO priority pathogen list for R&D of new antibiotics, which highlights the global unmet need for new antibiotics against infectious bacteria [ 3 ].…”

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“…The study mentioned various methods to identify bacterial isolates, which were further subjected to antibiotic sensitivity testing as per CLSI guidelines. 2 We would like to add some comments regarding this study and suggest the criteria for identification and antibiotic sensitivity testing need to be urgently revisited:1. A minor change needs to be made in the title, which indicates it as a multicentric study involving several hospitals in Northern Jordan, whereas author has collected samples from one single hospital.…”

“…The study mentioned various methods to identify bacterial isolates, which were further subjected to antibiotic sensitivity testing as per CLSI guidelines. 2 We would like to add some comments regarding this study and suggest the criteria for identification and antibiotic sensitivity testing need to be urgently revisited:…”