In vitro activity of conventional antifungal drugs and natural essences against the yeast-like alga Prototheca

Tortorano, Anna Maria; Prigitano, Anna; Dho, Giovanna; Piccinini, R.; Daprà, Valentina; Viviani, Maria Anna

doi:10.1093/jac/dkn107

Cited by 40 publications

(35 citation statements)

References 8 publications

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“…In addition, the drug has been found to have a higher margin of safety and fewer adverse effects when compared with other similar antifungal drugs (Katragkou and others 2011). Posaconazole also showed high in vitro activity against prototheca isolates from mastitis outbreaks in a dairy herd (Tortorano and others 2008). Therefore, it seems plausible that posaconazole could demonstrate superior efficacy against canine disseminated protothecosis when compared with other currently utilised therapies.…”

Section: Discussionmentioning

confidence: 99%

Use of posaconazole for treatment of disseminated protothecosis in a dog

Enders¹,

Olby²,

Mariani³

2016

Vet Record Case Reports

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A two-year-old female spayed Vizsla presented with progressive ataxia and visual deficits of three weeks’ duration and chronic intermittent large bowel diarrhoea. Protothecal organisms were identified on cytology of rectal scrapings and aspirates of intra-abdominal lymph nodes and Prototheca species were cultured from cerebrospinal fluid.Treatment with posaconazole for two weeks yielded a marked improvement, with progression of neurological signs noted after changing to itraconazole due to cost. The dog was humanely euthanased 31 days after diagnosis. The clinical improvement produced by posaconazole in this case suggests it may be an effective therapy for this typically fatal disease, but it may currently be cost prohibitive. To the authors’ knowledge, this is the first reported use of posaconazole for treatment of disseminated protothecosis in a dog.

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Section: Discussionmentioning

confidence: 99%

Use of posaconazole for treatment of disseminated protothecosis in a dog

Enders¹,

Olby²,

Mariani³

2016

Vet Record Case Reports

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“…Amphotericin B currently seems to be most effective agent, although the best treatment remains a matter of debate ( 1 , 4 , 7 ). Although in vitro susceptibility test results are not necessarily well correlated with results obtained in vivo, the low MIC of posaconazole reported here may be of interest in clinical practice ( 8 ). In the laboratory, use of selective yeast media, such as Sabouraud plus gentamicin, or Mycosis IC/F vials for blood culture, which contain chloramphenicol and tobramycin, may make it difficult to detect Prototheca spp.…”

mentioning

confidence: 69%

Fatal Algaemia in Patient with Chronic Lymphocytic Leukemia

Lanotte¹,

Baty²,

Sénécal³

et al. 2009

Emerg. Infect. Dis.

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“…têm demonstrado sensibilidade moderada (Segal et al 1976, McDonald et al 1984, Bexiga et al 2003, Buzzini et al 2004, Lass-Förl et al 2004, Tortorano et al 2008.…”

Section: Sensibilidade a Antimicrobianos E Tratamentounclassified

Prototecose: uma doença emergente

Camboim

Neves

Júnior³

et al. 2010

Pesq. Vet. Bras.

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Prototecose, causada por Prototheca zopfii ou P. wickerhamii, é uma doença emergente em animais e humanos. Em bovinos, P. zopfii é uma importante causa de mastite ambiental. Em cães e gatos, a prototecose é causada principalmente por P. zopfii. Em cães, causa infecção cutânea ou uma forma sistêmica envolvendo diversos órgãos. Em gatos, predominam as lesões tegumentares na região da face e plano nasal. No homem, a prototecose, causada principalmente por P. wickerhamii, manifesta-se sob três formas: cutânea, articular com bursite do olécrano e sistêmica. Pode ocorrer em indivíduos imunocompetentes, os quais podem apresentar bursite e/ou infecções cutâneas localizadas, ou em indivíduos imunossuprimidos, nos quais a enfermidade pode ser disseminada e/ou com envolvimento visceral. A prototecose causada por P. wickerhamii foi descrita recentemente em caprinos como causa de rinite afetando o vestíbulo nasal, união mucocutânea, pele da face e orelha. Nesta revisão são abordadas as características microbiologias e susceptibilidade a antimicrobianos do agente, e a epidemiologia, sinais clínicos, patologia, diagnóstico, tratamento e controle da prototecose em animais domésticos e no homem.

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In vitro activity of conventional antifungal drugs and natural essences against the yeast-like alga Prototheca

Abstract: Difficulties in treating animals with conventional drugs and the potent in vitro activity of essential oils demonstrated here raise the interest in further investigations on the therapeutic use of these non-conventional natural products.

Cited by 40 publications

References 8 publications

Use of posaconazole for treatment of disseminated protothecosis in a dog

Use of posaconazole for treatment of disseminated protothecosis in a dog

Fatal Algaemia in Patient with Chronic Lymphocytic Leukemia

Prototecose: uma doença emergente

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