2008
DOI: 10.1093/jac/dkn491
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In vitro activity of ciprofloxacin, moxifloxacin, vancomycin and erythromycin against planktonic and biofilm forms of Corynebacterium urealyticum

Abstract: This work demonstrates that C. urealyticum produces biofilms on polystyrene plates and biofilm-associated organisms are much less susceptible to the bactericidal effect of the antibiotics; and the exposure of C. urealyticum to erythromycin may favour resistance selection. Overall, these results may explain the difficulties for bacterial eradication in chronic infections caused by C. urealyticum.

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Cited by 32 publications
(32 citation statements)
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“…To the best of our knowledge, this is the first report of variable biofilm formation by different C. striatum strains isolated from blood specimens. Strains might escape from killing by producing robust biofilms, which have been reported to allow microorganisms to exchange genetic material and to become persistent colonizers and/or to gain greater resistance to antibiotics (39). These findings might explain why pattern A strains can survive in hospital patients for months or, even years.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge, this is the first report of variable biofilm formation by different C. striatum strains isolated from blood specimens. Strains might escape from killing by producing robust biofilms, which have been reported to allow microorganisms to exchange genetic material and to become persistent colonizers and/or to gain greater resistance to antibiotics (39). These findings might explain why pattern A strains can survive in hospital patients for months or, even years.…”
Section: Discussionmentioning
confidence: 99%
“…The following human pathogens were used in this work: Pseudomonas aeruginosa PA01 (Alonso et al 1999), Staphylococcus aureus 6538P (Lima et al 2014), Klebsiella pneumoniae DF12SA (Shahi et al 2013), Acinetobacter baumannii Ab13 (Poirel et al 2008), Burkholderia cenocepacia LMG 16656 and Burkholderia metallica LMG 24068 (Soriano et al 2009). The strains were routinely grown at 37°C in LB medium.…”
Section: Pathogenic Strainsmentioning
confidence: 99%
“…The respective data regarding minimal bactericidal concentration (MBC) of vancomycin, moxifloxacin, or ciprofloxacin for C. urealyticum biofilm is about two or three orders of magnitude greater than the MBC of respective planctonic forms (30). Therefore, we aimed to find out whether coryneform bacteria have a proclivity to produce biofilm in vitro .…”
Section: Discussionmentioning
confidence: 99%