In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain

In Vitro Activity of Cefditoren versus other Antibiotics against S. Pneumoniae Clinical Strains Isolated in Italy

“…The percentage values ofresistance to levofloxacin are lower than those described by Seral et al (20), and higher than those reported by Biedenbach et al (18), Stefani et al (3), and Blasi et al (2). It should be noted that the phenomenon of constant increase of resistance to levofloxacin has been well described by Jones et al (28) and by Despande et al (29).…”

“…The MIC 90 values of 0.5 ug/ml, also observed by other Authors (20,37), could be particularly significant in terms of therapeutic predictivity (PKI PO), as they cover all the strains even at a dosage of 200 mg bid (9) without increasing the dose.…”

“…Over the last few years cefditoren, a new wide spectrum oral cephalosporin (I, 6, 9, 12-15, 16-17, 20-21) characterized by a particular interaction with the PBP of penicillin-resistant strains (16)(17) has been particularly interesting for its good activity against the penicillin-resistant S. pneumoniae strains (I, 6,9,[12][13][14][15][16][17][18][19][20][21] In our study, there were 103 SPPR, 10.27%-of the isolates: this value is higher than that reported by previous multicenter studies (3), but lower than 11.2% reported by Montagnani et al in 2006 (30), higher than 6% reported by Mazzariol et al (31), similar to 10.2% reported by Montagnani et al in 2008 (32), and from 2 to 3 times lower than that reported by Blasi et al in 2009 (2). These alternating data clearly show the global behavior of the diffusion of resistance of a chromosomic nature; once the clone disappears, the data change.…”

“…Cefditoren (9) is a third generation oral (pivoxil ester) cephalosporin, characterized by a notable intrinsic anti-bacterial activity, wide spectrum of action, and extended activity against penicillin resistant S. pneumoniae (3,9,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). The aim of this study is to evaluate the incidence of the resistance/susceptibility ofS.…”

A Comparison of Cefditoren Pivoxil 8-12 mg/kg/day and Cefditoren Pivoxil 16-20 mg/kg/day in Treatment of Children With Acute Presumed Bacterial Rhinosinusitis: A Prospective, Randomized, Investigator-Blinded, Parallel-Group Study

“…Trimethoprim/sulfamethasoxazole, azithromycin, clarithromycin, or erythromycin are recommended if the patient has a history of immediate type I hypersensitivity reaction to β-lactams [ 6 ]. Cefditoren pivoxil (CDT; Meiact, Meiji Seika Pharma Co., Tokyo, Japan) is a third-generation oral cephalosporin with good activity against respiratory tract pathogens, including penicillin-intermediate and penicillin-resistant strains of S. pneumoniae as well as beta-lactamase producing strains of H. influenzae and M. catarrhalis [ 7 , 8 , 9 , 10 , 11 ]. For CDT, as for β-lactams, the time (t) (expressed as percentage of the dosing interval) that antibiotic concentrations exceed the value of minimum inhibitory concentration (MIC) (t>MIC) is the index predicting efficacy with a cutoff value of 40% for clinical cure in humans [ 12 , 13 ].…”