In utero Surfactant Administration to Preterm Human Fetuses using Endoscopy

Petrikovsky, Boris M.; Lysikiewicz, Andrzej; Маркін, Л. Б.; Słomko, Z

doi:10.1159/000264218

Cited by 29 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly there might be longer periods of ventilation in such infants due to premedication related respiratory depression. In order to avoid intubation but still administer surfactant, clinicians have tried fetal intrauterine surfactant administration using fiberoptic endoscope [20], nebulized surfactant [21], nasopharyngeal installation before delivery of shoulders [22] or using a laryngeal airway mask (LMA) [22].…”

Section: Discussionmentioning

confidence: 99%

Effect of surfactant therapy using an orogastric tube for tracheal catheterization in preterm newborns with respiratory distress

2016

View full text Add to dashboard Cite

Introduction: Respiratory distress syndrome (RDS) due to surfactant deficiency requires surfactant therapy for which InSurE method (Intubate, Surfactant, Extubate) has been widely used. However this method requires intubation and positive pressure ventilation, even for a short time which is enough to initiate significant lung injury. Recently, surfactant administration by Minimally Invasive Surfactant Therapy (MIST) using a fine catheter under direct laryngoscopy in spontaneously breathing preterms while on nCPAP has reported good outcomes. We prospectively assessed the outcome of a modified MIST method of surfactant administration using an orogastric tube in preterms with RDS. Materials & Methods: A single centre, prospective observational study was conducted where all consecutive eligible inborn preterm neonates with gestation age more than 24 weeks but less than 34 weeks and suffering from RDS were enrolled to receive surfactant using MIST. Results were compared with a historical cohort of preterm who received surfactant with INSURE techniques. Results: Sixty four cases in the modified MIST group were compared with a historic cohort of 68 cases in INSURE group. There were no differences in the requirement of intubation and mechanical ventilation in the first 72 hours but the duration of MV and CPAP were significantly less in modified MIST group. Other neonatal morbidities and mortality rates were similar in either of the groups. Conclusion: The modified MIST technique is an effective method for the treatment of RDS in preterms with better clinical efficacy and comparable outcomes than the more invasive INSURE procedure and deserves further evaluation.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of surfactant therapy using an orogastric tube for tracheal catheterization in preterm newborns with respiratory distress

2016

View full text Add to dashboard Cite

show abstract

“…Then the surfactant was injected into the mouths of the preterm fetuses through a catheter placed through the biopsy channel of the fiberscope. The worth of intrapartum endoscopy in the prophylactic administration of surfactant directly to the fetus, before the first breath, requires further clinical investigation [90]. …”

Section: Delivery Methods Of Pulmonary Surfactant Therapymentioning

confidence: 99%

Delivery and performance of surfactant replacement therapies to treat pulmonary disorders

El-Gendy

Kaviratna

Berkland

et al. 2013

Therapeutic Delivery

View full text Add to dashboard Cite

Lung surfactant is crucial for optimal pulmonary function throughout life. An absence or deficiency of surfactant can affect the surfactant pool leading to respiratory distress. Even if the coupling between surfactant dysfunction and the underlying disease is not always well understood, using exogenous surfactants as replacement is usually a standard therapeutic option in respiratory distress. Exogenous surfactants have been extensively studied in animal models and clinical trials. The present article provides an update on the evolution of surfactant therapy, types of surfactant treatment, and development of newer-generation surfactants. The differences in the performance between various surfactants are highlighted and advanced research that has been conducted so far in developing the optimal delivery of surfactant is discussed.

show abstract

“…Using this technique, Petrikovsky et al [7] introduced a gas-sterilized intraoperative fiberscope through the cervical canal into the amniotic cavity after spontaneous rupture of membranes during preterm labor. Using this approach the investigators injected surfactant into the mouths of 3 preterm fetuses through a catheter placed through the biopsy channel of the fiberscope.…”

Section: Intra-amniotic Instillation Of Surfactantmentioning

confidence: 99%

Novel Approaches to Surfactant Administration

Gupta

Donn

2012

Critical Care Research and Practice

View full text Add to dashboard Cite

Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical evidence.

show abstract

In utero Surfactant Administration to Preterm Human Fetuses using Endoscopy

Cited by 29 publications

References 0 publications

Effect of surfactant therapy using an orogastric tube for tracheal catheterization in preterm newborns with respiratory distress

Effect of surfactant therapy using an orogastric tube for tracheal catheterization in preterm newborns with respiratory distress

Delivery and performance of surfactant replacement therapies to treat pulmonary disorders

Novel Approaches to Surfactant Administration

Contact Info

Product

Resources

About