In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat

Łaźniewska, Joanna; Darby, Jack R. T.; Holman, Stacey L.; Sorvina, Alexandra; Plush, Sally E.; Massi, Massimiliano; Brooks, Doug A.; Morrison, Janna L.

doi:10.1002/jbio.202000322

Cited by 4 publications

(1 citation statement)

References 109 publications

(133 reference statements)

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“…Of note, maternal undernutrition of species where placental transport of fatty acids is low (e.g., sheep and rats) results in a decrease in BAT deposition. This effect can be enhanced by a reduction in placental size or its ability to transport glucose during maternal undernutrition [ 108 ].…”

Section: Intrinsic Factors Involved In the Generation Of Heat Through...mentioning

confidence: 99%

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

Bienboire-Frosini

Wang

Marcet-Rius

et al. 2023

Animals

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Hypothermia is one of the most common causes of mortality in neonates, and it could be developed after birth because the uterus temperature is more elevated than the extrauterine temperature. Neonates use diverse mechanisms to thermoregulate, such as shivering and non-shivering thermogenesis. These strategies can be more efficient in some species, but not in others, i.e., altricials, which have the greatest difficulty with achieving thermoneutrality. In addition, there are anatomical and neurological differences in mammals, which may present different distributions and amounts of brown fat. This article aims to discuss the neuromodulation mechanisms of thermoregulation and the importance of brown fat in the thermogenesis of newborn mammals, emphasizing the analysis of the biochemical, physiological, and genetic factors that determine the distribution, amount, and efficiency of this energy resource in newborns of different species. It has been concluded that is vital to understand and minimize hypothermia causes in newborns, which is one of the main causes of mortality in neonates. This would be beneficial for both animals and producers.

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Section: Intrinsic Factors Involved In the Generation Of Heat Through...mentioning

confidence: 99%

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

Bienboire-Frosini

Wang

Marcet-Rius

et al. 2023

Animals

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Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output

Dimasi

Łaźniewska

Plush

et al. 2021

Journal of Biophotonics

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Intrauterine growth restriction (IUGR) is a result of limited substrate supply to the developing fetus in utero, and can be caused by either placental, genetic or environmental factors. Babies born IUGR can have poor long-term health outcomes, including being at higher risk of developing cardiovascular disease. Limited substrate supply in the IUGR fetus not only changes the structure of the heart but may also affect metabolism and function of the developing heart. We have utilised two imaging modalities, two-photon microscopy and phase-contrast MRI (PC-MRI), to assess alterations in cardiac metabolism and function using a sheep model of IUGR. Two-photon imaging revealed that the left ventricle of IUGR fetuses (at 140-141 d GA) had a reduced optical redox ratio, suggesting a reliance on glycolysis for ATP production. Concurrently, the use of PC-MRI to measure foetal left ventricular cardiac output (LVCO) revealed a positive correlation between LVCO and redox ratio in IUGR, but not control fetuses. These data suggest that altered heart metabolism in IUGR fetuses is indicative of reduced cardiac output, which may contribute to poor cardiac outcomes in adulthood.

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Development of an optical fiber‐based redox monitoring system for tissue metabolism

Zhang

Sorvina

Morrison

et al. 2022

Journal of Biophotonics

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An optical redox ratio can potentially be used to report on the dynamics of cell and tissue metabolism and define altered metabolic conditions for different pathologies. While there are methods to measure the optical redox ratio, they are not particularly suited to real‐time in situ or in vivo analysis. Here, we have developed a fiber‐optic system to measure redox ratios in cells and tissues and two mathematical models to enable real‐time, in vivo redox measurements. The optical redox ratios in tissue explants are correlated directly with endogenous NADH/FAD fluorescence emissions. We apply the mathematical models to the two‐photon microscopy data and show consistent results. We also used our fiber‐optic system to measure redox in different tissues and show consistent results between the two models, hence demonstrating proof‐of‐principle. This innovative redox monitoring system will have practical applications for defining different metabolic disease states.

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In utero substrate restriction by placental insufficiency or maternal undernutrition decreases optical redox ratio in foetal perirenal fat

Cited by 4 publications

References 109 publications

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period

Redox ratio in the left ventricle of the growth restricted fetus is positively correlated with cardiac output

Development of an optical fiber‐based redox monitoring system for tissue metabolism

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