In Utero Alcohol Exposure and Prediction of Alcohol Disorders in Early Adulthood

Alati, Rosa; Mamun, Abdullah Al; Williams, Gail M.; O’Callaghan, Michael; Najman, Jake M.; Bor, William

doi:10.1001/archpsyc.63.9.1009

Cited by 202 publications

(174 citation statements)

References 30 publications

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“…This statement is of potential significance to the field of ethanol research given that clinical and epidemiological studies provide strong data for a predictive relationship between prenatal ethanol exposure and the risk for ethanol abuse in adolescent and young adults (Alati et al, 2006;Baer, Bar, Bookstein, Sampson, & Streissguth, 1998;Streissguth, 1998;Yates, Cadoret, Troughton, Steward, & Giunta, 1998).…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 94%

Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.

Youngentob¹,

Kent²,

Sheehe³

et al. 2007

Behavioral Neuroscience

146

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Human fetal ethanol exposure is strongly associated with ethanol avidity during adolescence. Evidence that intrauterine olfactory experience influences chemosensory-guided postnatal behaviors suggests that an altered response to ethanol odor resulting from fetal exposure may contribute to later abuse risk. Using behavioral and neurophysiological methods, the authors tested whether ethanol exposure via the dam's diet resulted in an altered responsiveness to ethanol odor in infant and adult rats. Compared with controls, (a) fetal exposure tuned the neurophysiologic response of the olfactory epithelium to ethanol odor at some expense to its responsiveness to other odorants in infantile rats-this effect was absent in adults; (b) the neural effect in infantile rats was paralleled by an altered behavioral response to ethanol odor that was specific to this odorant-this effect was also absent in adults; and (c) a significant component of the infantile behavioral effect was attributable to ethanol's effect on the olfactory neural modality. These data provide evidence for an important relationship between prenatal ethanol experience and postnatal behavioral responsiveness to the drug that is modulated or determined by olfactory function. Keywords NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptThe chemical senses are among the earliest systems to develop (Gottlieb, 1971;Schaal & Orgeur, 1992;Smotherman & Robinson, 1990), and in the chemosensory world of the uterus, they may have a unique salience. This statement is of potential significance to the field of ethanol research given that clinical and epidemiological studies provide strong data for a predictive relationship between prenatal ethanol exposure and the risk for ethanol abuse in adolescent and young adults (Alati et al., 2006;Baer, Bar, Bookstein, Sampson, & Streissguth, 1998;Streissguth, 1998;Yates, Cadoret, Troughton, Steward, & Giunta, 1998).It is well documented that olfactory function is fundamental to regulating a variety of biological processes, such as reproduction, food intake, and different social behaviors. Even communication between conspecific and heterospecific animals relies heavily on the reception and processing of odors produced by body glands and even feces and urine. Given this profound level of functional importance, not surprisingly, experience-induced plasticity in response to odorants is a means by which the olfactory system can be tuned to emphasize the transduction of stimuli that are deemed relevant within the animal's environment (Hudson, 1993(Hudson, , 1999. A variety of data indicate that the olfactory system is plastic in response to the odorant environment and have been gathered using different experimental manipulations, such as selective odorant exposure in neonates (Coopersmith & Leon, 1984;Johnson, Woo, Duong, Nguyen, & Leon, 1995;McCollum, Woo, & Leon, 1997;McLean & Harley, 2004;Sullivan & Leon, 1986;Sullivan, McGaugh, & Leon, 1991;Sullivan, Wilson, & Leon, 1989;Woo, Coopersmith, & Leon, 1987;Wo...

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Section: Nih-pa Author Manuscriptmentioning

confidence: 94%

Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.

Youngentob¹,

Kent²,

Sheehe³

et al. 2007

Behavioral Neuroscience

146

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“…New evidence suggests that prenatal alcohol exposure may increase the risk of alcohol dependence in adolescence (Alati et al 2006) and at 21 years of age (Baer et al 2003). Follow-up of 2,555 youth (35 per cent) from a large Australian birth cohort study (n=7,223) suggests the risk of developing early-onset alcohol abuse disorder (at between 13 and 17 years of age) was higher in those exposed to three or more standard drinks in early pregnancy than in those exposed to less alcohol after adjusting for confounders and excluding those with a family history of alcohol problems (Alati et al 2006).…”

Section: Prenatal Alcohol Exposure and Alcohol Disorders In Adulthoodmentioning

confidence: 99%

Survey of alcohol-related presentations to Australasian emergency departments

et al. 2014

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Objective: To determine the proportion of alcohol‐related presentations to emergency departments (EDs) in Australia and New Zealand, at a single time point on a weekend night shift. Design, setting and participants: A point prevalence survey of ED patients either waiting to be seen or currently being seen conducted at 02:00 local time on 14 December 2013 in 106 EDs in Australia and New Zealand. Main outcome measures: The number of ED presentations that were alcohol‐related, defined using World Health Organization ICD‐10 codes. Results: At the 106 hospitals (92 Australia, 14 New Zealand) that provided data, 395 (14.3%; 95% CI, 13.0%–15.6%) of 2766 patients in EDs at the study time were presenting for alcohol‐related reasons; 13.8% (95% CI, 12.5%–15.2%) in Australia and 17.9% (95% CI, 13.9%–22.8%) in New Zealand. The distribution was skewed left, with proportions ranging from 0 to 50% and a median of 12.5%. Nine Australian hospitals and one New Zealand hospital reported that more than a third of their ED patients had alcohol‐related presentations; the Northern Territory (38.1%) and Western Australia (21.1%) reported the highest proportions of alcohol‐related presentations. Conclusions: One in seven ED presentations in Australian and New Zealand at this 02:00 snapshot were alcohol‐related, with some EDs seeing more than one in three alcohol‐related presentations. This confirms that alcohol‐related presentations to EDs are currently underreported and makes a strong case for public health initiatives.

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“…There were a number of limitations in our study; one is the small sample size of program participants and caregivers. Although there have been studies where larger sample sizes have been used (Alati et al, 2006;Barr et al, 2006;O'Connor, McCracken, & Best, 2006), small sample sizes continue to be a limitation within the FASD field. Recruiting and retaining participants in research studies who have PAE is challenging due to the inconsistency in caregivers and the instability of the adolescents' home environment.…”

Section: Limitations Of Studymentioning

confidence: 99%

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

Mariasine¹,

Pei²,

Poth³

et al. 2014

IJPS

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Three key areas of dysfunction reported as having a significant impact on how adolescents with Prenatal Alcohol Exposure (PAE) navigate their teen years and work towards independence are: mental health, social skills, and adaptive functioning. However, little is known about how adolescents with PAE perceive their own functioning relative to others, and what they and others see as potential strengths on which they may build. Participants included 32 adolescents (17 male, 15 female); 31% had confirmed prenatal exposure to alcohol (PAE) and the remaining 69% had a diagnosis of a Fetal Alcohol Spectrum Disorder (FASD). Adolescents and their caregivers completed the following measures: ABAS-2 (adaptive skills), SSIS (social skills), BASC-2 (mental health functioning), and BERS-2 (personal strengths). Overall, caregivers rated adolescents as having significantly more difficulties across all measures assessed when compared to the adolescents. The only area of agreement between caregiver and adolescents prenatally exposed to alcohol was on career strength. The knowledge gained from the results of this exploratory study can help adolescents with PAE better understand themselves and help researchers to better characterize this population.

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In Utero Alcohol Exposure and Prediction of Alcohol Disorders in Early Adulthood

Cited by 202 publications

References 30 publications

Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.

Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats.

Survey of alcohol-related presentations to Australasian emergency departments

Adaptive Functioning, Social Skills, Mental Health, and Personal Strengths among Adolescents with Prenatal Alcohol Exposure (PAE)

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