In Stored Human Blood, The Inhibitor Effect of Tannic Acid and Caffeic Acid on Lipid Peroxidation and Oxidative DNA Damage

Huyut, Zübeyir; Şekeroğlu, Mehmet Ramazan; Balahoroğlu, Ragıp; Hakan, Hamit; Çokluk, Erdem

doi:10.5505/ejm.2016.76476

Cited by 5 publications

(12 citation statements)

References 19 publications

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“…Because of a possible increase in 8-OHDG levels in stored blood can cause gene mutations and false protein coding after blood transfusion, it is important to prevent injury in the DNA bases. Increasing oxidative stress and decreasing antioxidant capacity due to storage time (3,9,15,17,26), especially OH . radicals, can lead to DNA oxidation by damaging nuclear proteins and DNA (9).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 60 µg/mL resveratrol and 60 µg/mL serotonin was added to the second and third group, respectively. For blood storage time and measurement intervals, time intervals specified by previous studies were selected (15,17,26). For this purpose, MDA and oxidized CoQ10 were measured in the samples taken at the beginning, 7, 14, 21 and 28 days in all groups.…”

Section: Establishment Of Groups and Measurement Intervalsmentioning

confidence: 99%

“…Also, he stated that serotonin exhibits more effective radical elimination and copper reduction activity than melatonin due to the -OH group present in the phenolic structure (24). We aimed to measure lipid peroxidation product MDA (25), mitochondrial damage indicator oxidized CoQ10 (26) and oxidative DNA damage indicator 8-OHdG/10 6 dG ratios in stored blood and determined the effects of serotonin and resveratrol addition on lipid peroxidation, mitochondria and DNA damage that have a negative effects on the shelf life of stored blood.…”

Section: Introductionmentioning

confidence: 99%

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Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Huyut¹,

Şekeroğlu²,

Hakan³

et al. 2018

Eastern J Med

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Section: Discussionmentioning

confidence: 99%

Section: Establishment Of Groups and Measurement Intervalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Huyut¹,

Şekeroğlu²,

Hakan³

et al. 2018

Eastern J Med

Self Cite

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“…Another marker of oxidative stress is ubiquinone 10 (CoQ10), which is a lipid structured compound of the mammalian mitochondrial electron chain that prevents damage caused by biomolecules and lipid peroxidation by playing a role in the production of active forms of ascorbic acid and tocopherol (9,16). CoQ10 is important for cardiac muscle function, and it plays a role as an antioxidant in cardiac disorders and heart failures.…”

mentioning

confidence: 99%

“…CoQ10 is important for cardiac muscle function, and it plays a role as an antioxidant in cardiac disorders and heart failures. CoQ10 is a strong antioxidant that protects cellular structure by eliminating free radicals (9,16,18). 8-hydroxy-2-deoxyguanosine (8-OHdG) is the most abundant marker of oxidative DNA damage.…”

mentioning

confidence: 99%

Serum malondialdehyde, coenzyme Q10 and 8-hydroxydeoxyguanosine levels in calves with foot-and-mouth disease

Özkan¹,

Huyut²,

Yıldırım³

et al. 2020

Medycyna Weterynaryjna

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Foot-and-mouth disease (FMD) is an acute, contagious viral disease in cattle that is associated with enormous economic losses in Turkey and worldwide. The purpose of this study was to determine changes in serum malondialdehyde (MDA), coenzyme Q10 (CoQ10), 8-hydroxydeoxyguanosine (8-OHdG) and deoxyguanosine (dG) and to perform histopathological examinations in calves with FMD. Thirty calves were studied, 20 of which were infected with FMD and 10 were free of the disease. Following a routine clinical examination, blood samples were obtained, and serum MDA, CoQ10, 8-OHdG and dG levels were determined. Necropsy and histopathological examinations were performed on dead calves with FMD. MDA and 8-OHdG/106dG levels were significantly higher in calves with FMD than in the control group. However, the increase in CoQ10 levels in calves with FMD, compared with the control group, was not statistically significant. Macroscopic examination of the heart tissue of calves with acute myocarditis revealed the presence of pale, yellowish gray-white necrotic muscle fibers in the ventricular wall of the heart. The muscle fibers in the myocardium were swollen and exhibited pyknotic nuclei and intense lymphocytic cell infiltration. In longitudinal sections, the muscle fibers were non-striated, swollen, and homogenously pink and contained pink nuclei. Between muscle fibers, intense mononuclear cell infiltration was observed. The findings of the present study indicate that oxidative stress is significantly increased in calves with FMD, and that oxidative DNA damage may play an important role in the etiopathogenesis of FMD. This is the first study to report CoQ10 and 8-OHdG levels in calves with FMD, and its findings may serve as the basis for future studies on this subject.

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Interactions of Free Radical Initiators and Antioxidants in Erythrocytes: An Ex Vivo Study

Anusha Berikai Ananthakrishna,

Hsieh,

Pallavi

et al. 2023

Cell Tiss. Biol.

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In Stored Human Blood, The Inhibitor Effect of Tannic Acid and Caffeic Acid on Lipid Peroxidation and Oxidative DNA Damage

Cited by 5 publications

References 19 publications

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Actions of resveratrol and serotonin added to stored bloods on lipid peroxidation and oxidative DNA damage

Serum malondialdehyde, coenzyme Q10 and 8-hydroxydeoxyguanosine levels in calves with foot-and-mouth disease

Interactions of Free Radical Initiators and Antioxidants in Erythrocytes: An Ex Vivo Study

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