(In)stability of ligands at the surface of inorganic nanoparticles: A forgotten question in nanomedicine?

Goas, Marine Le; Saber, Justine; Bolívar, Sara González; Rabanel, Jean‐Michel; Awogni, Jean-Marc; Boffito, Daria C.; Banquy, Xavier

doi:10.1016/j.nantod.2022.101516

Cited by 14 publications

(10 citation statements)

References 247 publications

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“…When IONPs are inserted into living organisms and encounter biological fluids, their surface immediately interacts with proteins and other macromolecules, producing a “protein corona” that can radically affect the aggregation state, nanomaterial size, and interfacial characteristics, thus influencing the uncontrollable biological behavior of IONPs [ 100 ]. Thus, this protein corona is primarily responsible for IONP disposition and is involved in slowing the nanoparticle degradation process [ 101 ]. However, significant deviations in IONPs with a corona produced from human plasma were detected as a function of the lipid adsorption profile [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review

et al. 2023

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Background One-third of the world's population has anemia, contributing to higher morbidity and death and impaired neurological development. Conventional anemia treatment raises concerns about iron bioavailability and gastrointestinal (GI) adverse effects. This research aims to establish how iron oxide nanoparticles (IONPs) interact with probiotic cells and how they affect iron absorption, bioavailability, and microbiota variation. Methods Pointing to the study of the literature and developing a review and critical synthesis, a robust search methodology was utilized by the authors. The literature search was performed in the PubMed, Scopus, and Web of Science databases. Information was collected between January 2017 and June 2022 using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) protocols for systematic reviews and meta-analyses. We identified 122 compatible research articles. Results The research profile of the selected scientific articles revealed the efficacy of IONPs treatment carried by probiotics versus conventional treatment. Therefore, the authors employed content assessment on four topics to synthesize previous studies. The key subjects of the reviewed reports are the characteristics of the IONPs synthesis method, the evaluation of cell absorption and cytotoxicity of IONPs, and the transport of IONPs with probiotics in treating anemia. Conclusions To ensure a sufficient iron level in the enterocyte, probiotics with the capacity to attach to the gut wall transport IONPs into the enterocyte, where the maghemite nanoparticles are released. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review

et al. 2023

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“…Surface ligands, as interfacial mediators, can bind onto the surface of nanomaterials and form a functionalized interface to maintain the stability and dispersion of materials. 45,46 Furthermore, the functional groups of surface ligands can act as bridges to promote the assembly of different building units via various interactions including electrostatic interactions, coordination, and covalent conjugation. 31,47 2.1.1 Electrostatic interaction-driven assembly.…”

Section: Assembly Of Mof Nanocompositesmentioning

confidence: 99%

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

Wang

et al. 2023

Nanoscale

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“…These bioactive ligands [ 27 ] of saccharides, nucleases, porphyrins, peptides, or amino acids can be molecules or anions [ 28 ] that donate a pair of electrons to the central metal in the polyelectrolytes [ 29 ] during the polymerisation of a coordination complex [ 30 , 31 ]. Therefore, the central metal has been used as a cation nod, the chemical surface of which can be manipulated to attract most API anions [ 32 , 33 ]. As a result, a highly ordered crystalline nanochip could be engineered with tailored DDS features and yet be biocompatible without conventional toxicity.…”

Section: Introductionmentioning

confidence: 99%

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Miskon

Zaidi

2022

Materials

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This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

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(In)stability of ligands at the surface of inorganic nanoparticles: A forgotten question in nanomedicine?

Cited by 14 publications

References 247 publications

Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review

Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

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