Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review

Abstract

Background One-third of the world's population has anemia, contributing to higher morbidity and death and impaired neurological development. Conventional anemia treatment raises concerns about iron bioavailability and gastrointestinal (GI) adverse effects. This research aims to establish how iron oxide nanoparticles (IONPs) interact with probiotic cells and how they affect iron absorption, bioavailability, and microbiota variation. Methods Pointing to the study of the literature and developing a review and critical synthesis, a robust search methodology was utilized by the authors. The literature search was performed in the PubMed, Scopus, and Web of Science databases. Information was collected between January 2017 and June 2022 using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) protocols for systematic reviews and meta-analyses. We identified 122 compatible research articles. Results The research profile of the selected scientific articles revealed the efficacy of IONPs treatment carried by probiotics versus conventional treatment. Therefore, the authors employed content assessment on four topics to synthesize previous studies. The key subjects of the reviewed reports are the characteristics of the IONPs synthesis method, the evaluation of cell absorption and cytotoxicity of IONPs, and the transport of IONPs with probiotics in treating anemia. Conclusions To ensure a sufficient iron level in the enterocyte, probiotics with the capacity to attach to the gut wall transport IONPs into the enterocyte, where the maghemite nanoparticles are released. Graphical Abstract

Neuroinflammation and Schizophrenia: New Therapeutic Strategies through Psychobiotics, Nanotechnology, and Artificial Intelligence (AI)

“…Nanotechnology has revolutionized the encapsulation and delivery of probiotics, using a variety of nanostructured materials to improve the viability and effectiveness of probiotics [115]. Among these materials are nanocellulose, with its crystals and nanofibers offering biocompatibility and low toxicity; magnesium oxide nanoparticles, noted for their high surface area and mechanical strength; chitosan nanoparticles, with cationic properties and biocompatibility; Eudragit S100 nanoparticles, which vary their solubility with pH; and starch nanoparticles, used in biomedical applications for their abundance in nature [16,116].…”