In solution SERS sensing using mesoporous silica-coated gold nanorods

Gao, Zhe; Burrows, Nathan D.; Valley, Nicholas A.; Schatz, George C.; Murphy, Catherine J.; Haynes, Christy L.

doi:10.1039/c6an01159d

Cited by 52 publications

(54 citation statements)

References 50 publications

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“…Owing to the strong dependence of the SERS signals intensity on the distance to the gold surface, only the molecules smaller than the pores and able to penetrate within the silica core can chemisorb to the gold surface and will then provide a Raman signal. The absence of a Raman signal for the AuNR@SiO 2 exposed to the largest thiol of the series indicated that the molecule was unable to reach the bottom of the mesopores but rather adsorbed to their walls [ 127 ].…”

Section: Methods Of Characterizationmentioning

confidence: 99%

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Pellas

Mazouzi

et al. 2020

Biosensors

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Nanoparticles made of coinage metals are well known to display unique optical properties stemming from the localized surface plasmon resonance (LSPR) phenomenon, allowing their use as transducers in various biosensing configurations. While most of the reports initially dealt with spherical gold nanoparticles owing to their ease of synthesis, the interest in gold nanorods (AuNR) as plasmonic biosensors is rising steadily. These anisotropic nanoparticles exhibit, on top of the LSPR band in the blue range common with spherical nanoparticles, a longitudinal LSPR band, in all respects superior, and in particular in terms of sensitivity to the surrounding media and LSPR-biosensing. However, AuNRs synthesis and their further functionalization are less straightforward and require thorough processing. In this paper, we intend to give an up-to-date overview of gold nanorods in LSPR biosensing, starting from a critical review of the recent findings on AuNR synthesis and the main challenges related to it. We further highlight the various strategies set up to coat AuNR with a silica shell of controlled thickness and porosity compatible with LSPR-biosensing. Then, we provide a survey of the methods employed to attach various bioreceptors to AuNR. Finally, the most representative examples of AuNR-based LSPR biosensors are reviewed with a focus put on their analytical performances.

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Section: Methods Of Characterizationmentioning

confidence: 99%

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Pellas

Mazouzi

et al. 2020

Biosensors

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“…In this case, the SERS signal intensity was dependent on the Ag satellite size and nanogap distances. Similarly, SiO 2 coated Au NPs have been employed as SERS active platforms for the detection of organic compounds, such as organic dyes, thiol compounds and biomolecules . Certain analytes might also induce the aggregation of the NPs, thus creating SERS active sites that result in high enhancement factors.…”

Section: Sers and Water Quality Analysismentioning

confidence: 99%

Functionalized Inorganic Nanoparticles for Magnetic Separation and SERS Detection of Water Pollutants

et al. 2018

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Inorganic nanoparticles (NPs) have emerged in the last decades as key materials for a number of technologies. In particular, noble metal (Ag, Au) and iron oxide NPs have revealed important applications due to their plasmonic and magnetic properties, respectively. Among these applications, this review provides, on one hand, an overview on the use of colloidal metal NPs in surface enhanced Raman scattering (SERS) chemical analysis and, on the other hand, the application of iron oxides as a new class of nanosorbents for water pollutants. These distinct types of NPs are the main building blocks to produce [a] Raman spectroscopy is a powerful analytical tool for chemical characterization, providing information about molecular structure, surface processes, and interface reactions. [31,32] Raman spectroscopy is based on the inelastic scattering of photons by chemical species and materials (Raman scattering). Among the incident photons that hit the sample only a small portion is inelastically scattered, i.e. comes out at a different frequency from the incident light. The spectral information is based on the detection of these scattered photons that are recorded as energy shifts (Raman shifts) from the wavenumber of the elastic scattered photons (Rayleigh scattering). Each band in the Raman spectrum can be assigned to a vibrational mode (or Paula

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“…Gold nanorods (GNRs) display superior tunability in SPR absorbing through altering the length–breadth ratio and show pretty function in transforming light of NIR to heat energy; furthermore, light in NIR has maximum penetrating depth into human tissues. 17 - 21 …”

Section: Introductionmentioning

confidence: 99%

The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods

Xing

et al. 2018

Dose-Response

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Background:Polyacrylic acid (PAA)–coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected.Methods:It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell.Results:The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time–dose dependence.Conclusion:The results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma.

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In solution SERS sensing using mesoporous silica-coated gold nanorods

Abstract: Mesoporous silica-coated gold nanorods (AuNR@MS) act as a colloidally stable Raman sensing platform with a built-in analyte size cutoff.

Cited by 52 publications

References 50 publications

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Gold Nanorods for LSPR Biosensing: Synthesis, Coating by Silica, and Bioanalytical Applications

Functionalized Inorganic Nanoparticles for Magnetic Separation and SERS Detection of Water Pollutants

The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods

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