The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods

S, Pan; Xing, Hongcun; Fu, Xuqi; Yu, Hongmei; Yang, Zhaogang; Yang, Yudan; Sun, Weibo

doi:10.1177/1559325818789841

Cited by 20 publications

(15 citation statements)

References 37 publications

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“…Over the past few decades, many nanoparticles‐based delivery systems have been developed and employed in clinical diagnosis and therapy (Z. Chen et al, ; Z. Chen et al, ; Ma et al, ; Pan et al, ; Z. Yang et al, ; C. Zhou, Yang, & Teng, ). For cancer immunotherapy, nanoparticle‐based platforms can be divided into two types according to the substrate component: naturally derived nanoparticles and synthetic nanoparticles.…”

Section: Nanoparticle‐based Platforms For Cancer Immunotherapymentioning

confidence: 99%

Nanotechnology platforms for cancer immunotherapy

Yang

Zhao

et al. 2019

WIREs Nanomed Nanobiotechnol

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100

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Various cancer therapies have advanced remarkably over the past decade. Unlike the direct therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the host's immune system to detect specific cancer cells for efficient elimination. Nanoparticles incorporating immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance antitumor immunity. Such nanoparticle‐based cancer immunotherapies have received considerable attention and have been extensively studied in recent years. This review thus focuses on nanoparticle‐based platforms (especially naturally derived nanoparticles and synthetic nanoparticles) utilized in recent advances; summarizes delivery systems that incorporate various immune‐modulating agents, including peptides and nucleic acids, immune checkpoint inhibitors, and other small immunostimulating agents; and introduces combinational cancer immunotherapy with nanoparticles, especially nanoparticle‐based photo‐immunotherapy and nanoparticle‐based chemo‐immunotherapy. Undoubtedly, the recent studies introduced in this review prove that nanoparticle‐incorporated cancer immunotherapy is a highly promising treatment modality for patients with cancer. Nonetheless further research is needed to solve safety concerns and improve efficacy of nanoplatform‐based cancer immunotherapy for future clinical application. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Nanoparticle‐based Platforms For Cancer Immunotherapymentioning

confidence: 99%

Nanotechnology platforms for cancer immunotherapy

Yang

Zhao

et al. 2019

WIREs Nanomed Nanobiotechnol

Self Cite

100

View full text Add to dashboard Cite

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“… 6 - 8 In particular, it can reduce the side effects of chemotherapy on patients, reduce the adverse events caused by chemotherapy, improve the quality of life of patients, and prolong the survival time. 9 - 13 Several recent studies have shown that nanomaterials can penetrate biofilms and enter cells, tissues, and organs that larger size particles usually cannot penetrate, delivering drugs to locations that are difficult to reach with conventional chemotherapy drugs. 14 - 18 There are currently several formulations based on NPs delivery on the market, and others are at different stages of development.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology

et al. 2020

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Chemotherapy is widely used to treat cancer. The toxic effect of conventional chemotherapeutic drugs on healthy cells leads to serious toxic and side effects of conventional chemotherapy. The application of nanotechnology in tumor chemotherapy can increase the specificity of anticancer agents, increase the killing effect of tumors, and reduce toxic and side effects. Currently, a variety of formulations based on nanoparticles (NPs) for delivering chemotherapeutic drugs have been put into clinical use, and several others are in the stage of development or clinical trials. In this review, after briefly introducing current cancer chemotherapeutic methods and their limitations, we describe the clinical applications and advantages and disadvantages of several different types of NPs-based chemotherapeutic agents. We have summarized a lot of information in tables and figures related to the delivery of chemotherapeutic drugs based on NPs and the design of NPs with active targeting capabilities.

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“…The samples are incubated for different periods (12 hours, 1 day, and 3 days) at 37 C under the humidified atmosphere (5% CO 2 ) and in dark. Established Cell Counting Kit 8 (CCK-8) assays, recognized as one typical method for measuring cell viability, 16 are performed to assess the metabolic activity of cells exposed to the SiNWs. With different incubation time, 10 mL of stock CCK-8 reagents are added to each well, and cells are then incubated for 4 hours at 37 C. Absorbance is measured at 450 nm using microplate reader (Bio-Rad 680; Bio-Rad, Hercules, CA).…”

Section: Cell Counting Kit 8 Assay and Cell Morphology Observationmentioning

confidence: 99%

Cellular Toxicity Study of Silicon Nanowires

Song

Zheng

et al. 2020

Dose-Response

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The objective of this study was to achieve the practical bioapplications of silicon nanowires (SiNWs). In this study, the tumor and normal cell lines were used as models to systematically investigate the cytotoxicity of SiNWs synthesized by HF-assisted etching methods. Morphology observation, Cell Counting Kit 8, real-time polymerase chain reaction, and flow cytometry analysis were used to elucidate the cytotoxicity of SiNWs. The results showed that the cytotoxicity of SiNWs is greatly dependent on cell lines, SiNWs concentration, and incubation time. Particularly, SiNWs show better biocompatibility with tumor cell lines (eg, human epithelial cervical cancer [Hela] cells and human hepatocellular liver carcinoma [HepG2] cells) than normal cell lines (eg, human normal liver [HL-7702] cells and human embryonic kidney [HEK293T] cells). The reasons may be that SiNWs could tightly attach to the cell membrane in the cell medium, which obviously affects cell adhesion and inhibits their cell viability, especially for normal cell lines. From systematical analysis and comparison, we obtain the concentration limits of SiNWs, which may advance SiNWs applications and its toxicological study in vitro.

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The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods

Cited by 20 publications

References 37 publications

Nanotechnology platforms for cancer immunotherapy

Nanotechnology platforms for cancer immunotherapy

Nanoparticle-Based Drug Delivery System: A Patient-Friendly Chemotherapy for Oncology

Cellular Toxicity Study of Silicon Nanowires

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