In Situ Self‐Folding Assembly of a Multi‐Walled Hydrogel Tube for Uniaxial Sustained Molecular Release

Abstract

This study presents a multi-walled poly(ethylene glycol) diacrylate hydrogel tube formed by the simple self-folding of a bi-layered hydrogel patch. The gel tube has the capability to release encapsulated molecules through designated pathways in a sustained manner. Therefore, the gel tube encapsulating the vascular endothelial growth factor significantly increases the vascular densities and vessel diameters at an implantation site.

Shape-Switching Microrobots for Medical Applications: The Influence of Shape in Drug Delivery and Locomotion

“…21 Additionally, a more significant effect could be achieved by applying ON−OFF cycles (2 min ON, 2 min OFF) that forced the samples to alternatively open and close. This motion resulted in an increase of ca.…”

Self‐Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds

“…Here, the internal part of the folded tube was formed by the soft or high molecular weight PEGDA, while the external part was represented by the low molecular weight PEGDA. Despite in the literature, the preferential arrangement was represented by the wrapping of the low molecular weight PEGDA in the internal part, [24][25][26] the addition of the sacrificial layer during fabrication influenced the rolling behavior of PEGDA bilayers. The internal stresses generated at the interface between gelatin and the first photo-crosslinked PEGDA, due to of interpenetration between the two polymers, promoted the bilayer rolling toward the freer side (as shown in Video S1, Supporting Information), promoting the above-mentioned spatial organization (see the Supporting Information for a detailed discussion).…”

“…Here, the formation of self‐folded tubular structures with encapsulated cells from poly(ethylene glycol) diacrylate (PEGDA) hydrogel bilayers is reported. PEGDA hydrogels have previously been used in developing self‐folding structures, microrobots, and tissue scaffolds upon swelling . In vitro 3D models have been proposed to encapsulate cells within hydrogels for mimicking in vivo structural cues.…”

Material-mediated proangiogenic factor release pattern modulates quality of regenerated blood vessels

“…It was assumed that hydrogel arrays were embedded in the top of the membrane. In this numerical analysis, diffusion coefficients of drug in media, tissue, and hydrogel were approximated to be 100 μm 2 /s, 1 μm 2 /s, and 0.02 μm 2 /s, respectively [24] . The units used for all simulations were meters, seconds, and kilograms.…”