Material-mediated proangiogenic factor release pattern modulates quality of regenerated blood vessels

Rich, Max H.; Lee, Min Kyung; Baek, Kwang-Hyun; Jeong, Jae Hyun; Kim, Dong Hyun; Millet, Larry J.; Bashir, Rashid; Kong, Hyunjoon

doi:10.1016/j.jconrel.2014.10.020

Cited by 13 publications

(9 citation statements)

References 41 publications

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“…The release of molecules from the scaffold can be controlled by modifying the properties and composition of the material, TABLE 1 | List of common bioactive molecules used in tissue engineering vascularization and mentioned in this review. Lee et al, 2001;Gerhardt et al, 2003;Chiu and Radisic, 2010;Chow et al, 2010;Yuen et al, 2010;Shah et al, 2011;Zheng et al, 2012;Brudno et al, 2013;Nguyen et al, 2013;Alsop et al, 2014;Lai et al, 2014;Rich et al, 2014;Stamati et al, 2014;Wu et al, 2016;LaValley et al, 2017;Turner et al, 2017;Kuttappan et al, 2018;Stejskalová et al, 2019;Wang et al, 2019FGF Chow et al, 2010Tengood et al, 2011;Lai et al, 2014;Stamati et al, 2014;Kuttappan et al, 2018;Dong et al, 2019IGF Holland et al, 2005EGF Lai et al, 2014PDGF Tengood et al, 2011Brudno et al, 2013;Lai et al, 2014;Stejskalová et al, 2019;Wang et al, 2019Glycosaminoglycans Chow et al, 2010Chow et al, 2014;Wu et al, 2016 Frontiers in Bioengineering and Biotechnology | www.frontiersin.org as well as changing the method of retaining the drug (King and Krebsbach, 2012). Boontheekul et a...…”

Section: Degradation Dependent Releasementioning

confidence: 99%

“…They reported greater cell infiltration into the scaffold and presence of immature vascular networks. Similarly, hydrogels have been designed that induce directional vessel growth via pre-defined release of VEGF (Rich et al, 2014).…”

Section: Patterning Of Bioactive Moleculesmentioning

confidence: 99%

“…Endothelial cells are the primary cell type driving angiogenesis, however, their use alone is often not sufficient to recapitulate physiological angiogenesis in TE applications (Costa-Almeida et al, 2014). Angiogenesis in vivo involves complex signaling pathways between ECs and other associated supportive cells, such as pericytes and macrophages (Ribatti and Crivellato, 2009;Cathery et al, 2018). In order to mimic this natural process, researchers have used combinations of proangiogenic cells to promote the vascularization of scaffolds.…”

Section: Interactions With Other Cellsmentioning

confidence: 99%

“…Macrophage phenotypes vary along a spectrum from a pro-inflammatory M1 state to a pro-healing M2 state (Moore and West, 2019), resulting in certain subsets of macrophages triggering inflammation, and others tissue healing, after injury. Pro-healing macrophages act by secreting proangiogenic factors that promote endothelial proliferation and migration, resulting in neovascularization (Ribatti and Crivellato, 2009). Moreover, macrophages play a key role in vascular anastomosis, which further highlights their potential for use in the vascularization of tissue engineered constructs (Fantin et al, 2010).…”

Section: Macrophagesmentioning

confidence: 99%

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Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo

Cathery

Velliou

et al. 2020

Front. Bioeng. Biotechnol.

128

109

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Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

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Section: Degradation Dependent Releasementioning

confidence: 99%

Section: Patterning Of Bioactive Moleculesmentioning

confidence: 99%

Section: Interactions With Other Cellsmentioning

confidence: 99%

Section: Macrophagesmentioning

confidence: 99%

See 2 more Smart Citations

Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo

Cathery

Velliou

et al. 2020

Front. Bioeng. Biotechnol.

128

109

View full text Add to dashboard Cite

show abstract

“…In DFUs, the synthesis and secretion of these biomolecules are altered due to impaired cell functions in response to the high-glucose microenvironment. To improve the commercially available bioartificial dermal template or scaffolds for DFU wound management, multiple growth factors can be incorporated into the products [ 139 , 140 , 141 , 142 ]. For example, the inclusion and delivery of VEGF in 3D-bioprinted scaffolds has been shown to increase the proliferation of endothelial cells and vascularization in vivo [ 141 , 142 ].…”

Section: Three-dimensional Bioprinting Approaches To Aid Wound Repmentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.

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From Arteries to Capillaries: Approaches to Engineering Human Vasculature

Fleischer

Tavakol

Vunjak-Novakovic

2020

Adv Funct Materials

111

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From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple scales and cell types. The convergence of bioengineering, materials science, and stem cell biology has enabled tissue engineers to recreate the structure and function of different hierarchical levels of the vascular tree. Engineering large‐scale vessels aims to replace damaged arteries, arterioles, and venules and their routine application in the clinic may become a reality in the near future. Strategies to engineer meso‐ and microvasculature are extensively explored to generate models for studying vascular biology, drug transport, and disease progression as well as for vascularizing engineered tissues for regenerative medicine. However, bioengineering tissues for transplantation has failed to result in clinical translation due to the lack of proper integrated vasculature for effective oxygen and nutrient delivery. The development of strategies to generate multiscale vascular networks and their direct anastomosis to host vasculature would greatly benefit this formidable goal. In this review, design considerations and technologies for engineering millimeter‐, meso‐, and microscale vessels are discussed. Examples of recent state‐of‐the‐art strategies to engineer multiscale vasculature are also provided. Finally, key challenges limiting the translation of vascularized tissues are identified and perspectives on future directions for exploration are presented.

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Material-mediated proangiogenic factor release pattern modulates quality of regenerated blood vessels

Cited by 13 publications

References 41 publications

Angiogenesis in Tissue Engineering: As Nature Intended?

Angiogenesis in Tissue Engineering: As Nature Intended?

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

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