In situ real-time investigation of cancer cell photothermolysis mediated by excited gold nanorod surface plasmons

Chen, Cheng-Lung; Kuo, Ling-Ru; Chang, C. L.; Hwu, Y.; Huang, Cheng-Kuang; Lee, Shin‐Yu; Chen, Kowa; Lin, Su‐Jien; Huang, Jing-Duan; Chen, Yang‐Yuan

doi:10.1016/j.biomaterials.2010.01.140

Cited by 95 publications

(71 citation statements)

References 24 publications

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“…This is probably due to the toxic effect of the CTAB present in the coating of gold nanorods, as previously described. 35,38 The mechanism by which CTAB induces cytotoxicity has also been described in depth. 39 CTAB is a cationic surfactant, and cations may induce mitochondria dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, more striking hyperthermic effects were obtained when gold nanorods were deposited on the surface of cells, and the cell membrane appears to be the most susceptible cellular component to thermal damage. 34 Although it has been reported that the energy threshold for cell therapy depends significantly on the number of nanorods taken up per cell, 35 other authors have shown that cancer cell death may occur in response to extracellular hyperthermia induced by gold nanorods. 36 Our results indicate that extracellular gold nanorods remaining in the culture medium without being internalized by 1321N1 cells could also lead to effective cell destruction within a relative short period of time and using a laser intensity that does not affect cell survival in the absence of gold nanorods.…”

Section: Discussionmentioning

confidence: 99%

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Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Fernández‐Cabada¹,

Pablo²,

Serrano³

et al. 2012

IJN

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Background: Metallic nanorods are promising agents for a wide range of biomedical applications. In this study, we developed an optical hyperthermia method capable of inducing in vitro death of glioblastoma cells. Methods: The procedure used was based on irradiation of gold nanorods with a continuous wave laser. This kind of nanoparticle converts absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. The effectiveness of the method was determined by measuring changes in cell viability after laser irradiation of glioblastoma cells in the presence of gold nanorods. Results: Laser irradiation in the presence of gold nanorods induced a significant decrease in cell viability, while no decrease in cell viability was observed with laser irradiation or incubation with gold nanorods alone. The mechanism of cell death mediated by gold nanorods during photothermal ablation was analyzed, indicating that treatment compromised the integrity of the cell membrane instead of initiating the process of programmed cell death. Conclusion:The use of gold nanorods in hyperthermal therapies is very effective in eliminating glioblastoma cells, and therefore represents an important area of research for therapeutic development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Fernández‐Cabada¹,

Pablo²,

Serrano³

et al. 2012

IJN

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“…35 Some groups also reported that GNRs could be used as promising agents for cancer cell photothermolysis. 10,31 In the case of in vivo plasmonic photothermal therapy, Dickerson et al 17 demonstrated the feasibility of photothermal therapy of deep-tissue malignancies using pegylated GNRs (PEG-NRs) and a small, portable, inexpensive cw NIR laser at 808 nm. PEG-NRs were intravenously injected into mice with HSC-3 tumor xenografts and were preferentially accumulated in tumor sites due to the enhanced permeability and retention (EPR) effect of tumor tissues.…”

Section: Gnrs As a Phototherapeutic Agentmentioning

confidence: 99%

Photothermal Cancer Therapy and Imaging Based on Gold Nanorods

et al. 2011

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Gold nanorods (GNRs), which strongly absorb near-infrared (NIR) light, have shown great potential in fields of biomedical application. These include photothermal therapy, molecular imaging, biosensing, and gene delivery, especially for the treatment of diseased tissues such as cancer. These biomedical applications of GNRs arise from their various useful properties; photothermal (nanoheater) properties, efficient large scale synthesis, easy functionalization, and colloidal stability. In addition, GNRs do not decompose and have an enhanced scattering signal and tunable longitudinal plasmon absorption which allow them to be used as a stable contrast agent. Therefore, GNRs are also promising theranostic agents, combining both tumor diagnosis and treatment. In this review, we discuss the recent progress of in vitro and in vivo explorations of the diagnostic and therapeutic applications of GNRs as a component of cancer therapy.

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“…Hyperthermia arises from a number of mechanisms, including cavitation effects caused by microbubble formation, disruption of cell membranes and denaturation of proteins [198][199][200]. This process is a highly localized phenomenon and confined to only those regions specifically targeted by bioconjugated metal NPs [201][202][203].…”

Section: Photothermal Ablation (Pta) Therapymentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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In situ real-time investigation of cancer cell photothermolysis mediated by excited gold nanorod surface plasmons

Cited by 95 publications

References 24 publications

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Induction of cell death in a glioblastoma line by hyperthermic therapy based on gold nanorods

Photothermal Cancer Therapy and Imaging Based on Gold Nanorods

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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