In situ preparation of non-viral gene vectors with folate/magnetism dual targeting by hyperbranched polymers

Shi, Yunfeng; Lei, Gaiying; Li, Yueyang; Zhang, Xiaoming; Peng, Rui; Hu, Jiaman; Yuan, Zibo; Liu, Yueli; Shen, Xueqi; Sun, Ning; Wang, Mengyue; He, Yaru; Wang, Jinhao; Du, Jimin; Zhou, Linzhu; Zhu, Xinyuan

doi:10.1016/j.eurpolymj.2020.109584

Cited by 1 publication

(1 citation statement)

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“…In most cases the formed hybrid nanostructures show efficient stabilization of MNPs in aqueous solutions [19,22,23]. Other biomedical applications of MNPs/polymer hybrid nanoparticles include magnetic hyperthermia [24][25][26] and drug delivery [27][28][29] for effective, active, and triggered release [30,31] of the entrapped drugs. Another interesting application of hybrid nanostructures, is that they could be used to remove polycyclic hydrocarbon pollutants from aqueous media [32].…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic P(OEGMA-co-DIPAEMA) Hyperbranched Copolymer/Magnetic Nanoparticle Hybrid Nanostructures by Co-Assembly

et al. 2022

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This work presents the utilization of amphiphilic poly(oligo(ethylene glycol) methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched (HB) copolymers, forming polymeric aggregates in aqueous media, as building nanocomponents and nanocarriers for the entrapment of magnetic cobalt ferrite nanoparticles (CoFe2O4, MNPs), and the hydrophobic drug curcumin (CUR) in their hydrophobic domains. Dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM) techniques were used to evaluate the multifunctional hybrid nanostructures formed in aqueous media by co-assembly of the components and their solution properties. Magnetic nanoparticles (MNPs) or MNPs/CUR were co-assembled effectively with pre-existing polymer aggregates, leading to well-defined hybrid nanostructures. Magnetophoresis experiments revealed that the hybrid nanostructures retain the magnetic properties of MNPs after their co-assembly with the hyperbranched copolymers. The hybrid nanostructures demonstrate a significant colloidal stability under physiological conditions. Furthermore, MNPs/CUR-loaded aggregates displayed considerable fluorescence as demonstrated by fluorescence spectroscopy. These hybrid nanostructures could be promising candidates for drug delivery and bio-imaging applications.

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