In situ preparation of fine particles and characterization of molecularly imprinted polymer for creatinine prepared from polymer anion and Al3+

Cho, Min Gi; Hyeong, Seonghoon; Park, Kyung Kgi; Chough, Sung Hyo

doi:10.1016/j.polymer.2021.123587

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Scatchard model was further applied to study the effect of zwitterionic functional groups on the binding affinity of MIPs as follows where Q max and K S are the Scatchard constants related to theoretical maximum adsorption capacity and binding affinity, respectively.…”

Section: Resultsmentioning

confidence: 99%

Constructing High-Recognition Protein-Imprinted Materials Using “Specially Designed” Block Macromolecular Chains as Functional Monomers and Crosslinkers

Song

Qian

Yang

et al. 2021

ACS Appl. Mater. Interfaces

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The use of a macromolecularly functional monomer and crosslinker (MFM) to stabilize and imprint a template protein is a new method to construct high-recognition protein-imprinted materials. In this study, for the first time, a “specially designed” block MFM with both “functional capability” and “crosslinking capability” segments was synthesized via reversible addition–fragmentation chain-transfer polymerization and used to fabricate bovine serum albumin (BSA)-imprinted microspheres (SiO2@MPS@MIPs-MFM) by the surface imprinting strategy. Results from circular dichroic spectrum experiments reflected that the block MFM could maintain the natural form of BSA, whereas its corresponding and equivalent micromolecularly functional monomer (MIM) seriously destroyed the secondary structure of proteins. Batch rebinding experiments showed that the maximum adsorption capacity and imprinting factor of SiO2@MPS@MIPs-MFM reached 314.9 mg g–1 and 4.02, which were significantly superior to that of MIM-based imprinted materials. In addition, since the crosslinking capability segments in block MFM involved zwitterionic functional groups with a protein-repelling effect, SiO2@MPS@MIPs-MFM showed better specific rebinding ability than the imprinted material prepared by MFM without this component. Besides, scanning electron microscopy and transmission electron microscopy images showed that the shell thickness of SiO2@MPS@MIPs-MFM was approximately 15 nm, and such a thin imprinted layer ensured its rapid adsorption equilibrium (120 min). As a result, SiO2@MPS@MIPs-MFM revealed fantastic selectivity and recognition ability in a mixed protein solution and could efficiently extract BSA from biological samples of bovine calf serum. The proposal of block MFM enriched the options and designability of monomers in protein imprinting technology, thereby laying a foundation for developing high-performance protein-imprinted materials.

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Section: Resultsmentioning

confidence: 99%

Constructing High-Recognition Protein-Imprinted Materials Using “Specially Designed” Block Macromolecular Chains as Functional Monomers and Crosslinkers

Song

Qian

Yang

et al. 2021

ACS Appl. Mater. Interfaces

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show abstract

“…To avoid the drawbacks and to increase the uptake and sorption selectivity could have been studied through the surface imprinting methods, [15,16] metal ion/polymer complex, [17] and direct mixing template and functional polymer without cross-linker in a cosolvent but to be insoluble in aqueous state. [18] When MIP particles were finer and more porous, the sorption could be increased.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective Molecularly Imprinted Polymer for Tyrosine, Tryptophan, and Phenylalanine, and the Possibility of the Crop‐Circle‐Like Imprinting

Cho,

Hyeong,

Park

et al. 2023

Macromol. Rapid Commun.

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Molecularly imprinted polymer (L‐MIP) for L‐tyrosine (L‐Tyr) is prepared by the complexation between quaternized poly(4‐vinylpyridine/divinylbenzene) (QVP) and poly(acrylamide‐co‐acrylic acid) (PAmA) in alkaline solution. The L‐MIP shows higher enantioselectivity for L‐isomers of tyrosine, together with tryptophan (Trp) and phenylalanine (Phe) compared to the D‐isomers of them. The sorption isotherms of the three D‐enantiomers are converged to one isotherm. It can reflect that the sorption of D‐enantiomers can be relied mainly on the common segment, ‐CH2‐CH(NH2)‐COOH, neglecting any effect of bulkier aromatic groups. The imprinted common segment can be opened on the surface of MIP from the D‐enantiomers. For the L‐enantiomers, the sorption discrepancies are depended on the size of the aromatic group implying that the phenolic moiety of L‐Tyr can be also opened. Thus, the imprinted sites are proposed to be opened on the surface of L‐MIP similar to the crop‐circle‐like. The enantioselectivity factors, αef = QL/QD, for Tyr, Trp, and Phe are 1.52, 1.30, and 1.52 for L‐ to D‐isomers, respectively. And the uptake differences between D‐ and L‐enantiomers of Tyr, Trp, and Phe are 31.8, 20.7, and 29 mg per 1 g MIP, respectively.

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“…Molecularly imprinted polymers (MIPs) are intelligent polymers that coassemble target molecules and functional monomers through covalent or noncovalent interactions [15,16]. The imprinted cavities distributed in the threedimensional network of MIPs can specifically recognize the target molecule [17]. Due to their mechanical and thermal stability, and high selectivity, MIPs have been widely used for adsorbent [18,19] and sensor [20].…”

Section: Introductionmentioning

confidence: 99%

Single‐crystal ordered macroporous metal‐organic framework as support for molecularly imprinted polymers and their integration in membrane formant for the specific recognition of zearalenone

Wang

Qiu

Wang

et al. 2021

J of Separation Science

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Zearalenone is a fungal contaminant that is widely present in grains. Here, a novel molecularly imprinted membrane based on SOM-ZIF-8 was developed for the rapid and highly selective identification of zearalenone in grain samples. The molecularly imprinted membrane was prepared using polyvinylidene fluoride, cyclododecyl 2,4-dihydroxybenzoate as a template and SOM-ZIF-8 as a carrier. The factors influencing the extraction of zearalenone using this membrane, including the solution pH, extraction time, elution solvent, elution time, and elution volume, were studied in detail. The optimized conditions were 5 mL of sample solution at pH 6, extraction time of 45 min, 4 mL of acetonitrile:methanol = 9:1 as elution solvent, and elution time of 20 min. This method displayed a good linear range of 12-120 ng/g (R 2 = 0.998) with the limits of detection and quantification of this method are 1.7 and 5.5 ng/g, respectively. In addition, the membrane was used to selectively identify zearalenone in grain samples with percent recoveries ranging from 87.9 to 101.0% and relative standard deviation of less than 6.6%. Overall, this study presents a simple and effective chromatographic pretreatment method for detecting zearalenone in food samples.

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In situ preparation of fine particles and characterization of molecularly imprinted polymer for creatinine prepared from polymer anion and Al3+

Cited by 5 publications

References 24 publications

Constructing High-Recognition Protein-Imprinted Materials Using “Specially Designed” Block Macromolecular Chains as Functional Monomers and Crosslinkers

Constructing High-Recognition Protein-Imprinted Materials Using “Specially Designed” Block Macromolecular Chains as Functional Monomers and Crosslinkers

Enantioselective Molecularly Imprinted Polymer for Tyrosine, Tryptophan, and Phenylalanine, and the Possibility of the Crop‐Circle‐Like Imprinting

Single‐crystal ordered macroporous metal‐organic framework as support for molecularly imprinted polymers and their integration in membrane formant for the specific recognition of zearalenone

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