Single‐crystal ordered macroporous metal‐organic framework as support for molecularly imprinted polymers and their integration in membrane formant for the specific recognition of zearalenone

Abstract

Zearalenone is a fungal contaminant that is widely present in grains. Here, a novel molecularly imprinted membrane based on SOM-ZIF-8 was developed for the rapid and highly selective identification of zearalenone in grain samples. The molecularly imprinted membrane was prepared using polyvinylidene fluoride, cyclododecyl 2,4-dihydroxybenzoate as a template and SOM-ZIF-8 as a carrier. The factors influencing the extraction of zearalenone using this membrane, including the solution pH, extraction time, elution solvent, elution time, and elution volume, were studied in detail. The optimized conditions were 5 mL of sample solution at pH 6, extraction time of 45 min, 4 mL of acetonitrile:methanol = 9:1 as elution solvent, and elution time of 20 min. This method displayed a good linear range of 12-120 ng/g (R 2 = 0.998) with the limits of detection and quantification of this method are 1.7 and 5.5 ng/g, respectively. In addition, the membrane was used to selectively identify zearalenone in grain samples with percent recoveries ranging from 87.9 to 101.0% and relative standard deviation of less than 6.6%. Overall, this study presents a simple and effective chromatographic pretreatment method for detecting zearalenone in food samples.

Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples

“…The analysis and control of toxic and harmful contaminants in foods have attracted significant attention in chemistry and food science [1]. It had been reported that the contaminants of zearalenone (ZEN) and its derivatives, such as zearalanone (ZAN), might tentatively cause many reproductive disorders, such as prostate, ovarian, cervical, and breast cancers [2,3]. ZEN and ZAN are produced by fusarium oxysporum and are commonly presented in spoiled corn, corn juice, and corn oil [4], which are almost insoluble in water, and readily soluble in organic solvents such as methanol and ACN [5].…”