In situ polydopamine functionalized poly-L-lactic acid nanofibers with near-infrared-triggered antibacterial and reactive oxygen species scavenging capability

Xiong, Feng; Wei, Shuo; Sheng, Han; Han, Xiang; Jiang, Wei; Zhang, Zhuojun; Li, Biyun; Xuan, Hongyun; Xue, Ye; Yuan, Huihua

doi:10.1016/j.ijbiomac.2022.01.024

Cited by 20 publications

(19 citation statements)

References 57 publications

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Section: Discussionmentioning

confidence: 99%

“…Super-hydrophilic PDA coating was reported to reduce the nonspecific adsorption of proteins and inhibit thrombus formation, provide significant antibacterial effects against both Gram-positive and Gram-negative bacteria, achieve stronger mechanical strength and enhance the photothermal effect. 111,112 Recently, Weldrick et al 54,66 have explored diverse ways to bring a new life into old antibiotics that have become ineffective due to development of AMR. They also proposed to use a protease enzyme with high isoelectric point to coat the nanogel loaded with a cationic antibiotic where the protease is being immobilized on the surface of the nanogel particles.…”

Section: Nanotechnology Strategies For Biofilm Targeting and Eradicationmentioning

confidence: 99%

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Nanotechnologies for control of pathogenic microbial biofilms

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Nanotechnology Strategies For Biofilm Targeting and Eradicationmentioning

confidence: 99%

Nanotechnologies for control of pathogenic microbial biofilms

et al. 2022

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“…Additionally, PDA was coated onto the surface of nephrite to emphasize antibacterial activity because it is frequently employed as an antibacterial coating material for various implants [ 22 ]. PDA coating on the surface of a biomaterial or implant endowed bioactive surfaces for therapeutic purposes [ 24 , 25 , 26 ]. Furthermore, a PDA layer on the biofilm endowed a synergistic effect to kill bacteria and a self-cleaning process [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…PDA is known to have antioxidant activity, i.e., PDA-crosslinked hydrogels efficiently scavenge 78.8% of free radicals in the biological system while only 1.4% of free radicals can be scavenged by hydrogels without PDA [ 21 ]. Furthermore, PDA has an antibacterial and antifungal efficacy against several microorganisms on the surface of medical devices by providing hydrophilic/charged surfaces [ 22 , 23 , 24 ]. Wang et al reported that PDA-containing composites demonstrate excellent antibacterial and long-term antibacterial properties against Gram-negative E. coli and Gram-positive S. aureus [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al reported that PDA-containing composites demonstrate excellent antibacterial and long-term antibacterial properties against Gram-negative E. coli and Gram-positive S. aureus [ 23 ]. Xiong et al reported that PDA-functionalized nanofibers have superior antimicrobial/ROS scavenging activity and a beneficial effect on damaged tissue repair [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens

Kang

Moon²,

Lee

et al. 2022

Materials

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The aim of this study is to prepare ciprofloxacin (CIP) or levofloxacin (LEVO)-incorporated and polydopamine (PDA)-coated nephrite composites for application in drug-eluting contact lenses. PDA was coated onto the surface of nephrite to improve antibacterial activity and to payload antibiotics. CIP or LEVO was incorporated into the PDA layer on the surface of nephrite. Furthermore, CIP-incorporated/PDA-coated nephrite composites were embedded into the contact lenses. PDA-coated nephrite composites showed dull and smooth surfaces according to the dopamine concentration while nephrite itself has sharp surface morphology. CIP- or LEVO-loaded/PDA-coated nephrite composites also have dull and smooth surface properties. Nano and/or sub-micron clusters were observed in field emission-scanning electron microscopy (FE-SEM) observation, indicating that PDA nanoparticles were accumulated and coated onto the surface of nephrite. Furthermore, CIP- or LEVO-incorporated/PDA-coated nephrite composites showed the sustained release of CIP or LEVO in vitro and these properties contributed to the enhanced antibacterial activity of composites compared to nephrite or PDA-coated nephrite composites. CIP-incorporated/PDA-coated nephrite composites were embedded in the contact lenses and then, in an antibacterial study, they showed higher bactericidal effect against Staphylococcus aureus (S. aureus) compared to nephrite itself or PDA-coated nephrite composites. We suggest that CIP- or LEVO-loaded/PDA-coated nephrite composite-embedded contact lenses are a promising candidate for therapeutic application.

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Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells

Liu,

Luo,

Liao

et al. 2024

J Biomed Mater Res

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Strontium (Sr) has important functions in bone remodeling. Incorporating strontium‐doped α‐calcium sulfate hemihydrate (SrCSH) into poly(lactic‐co‐glycolic acid) (PLGA) fibrous scaffolds were expected to increase its bio‐activity and provide a potential material for bone tissue engineering. In the present study, Sr‐containing aligned PLGA/SrCSH fibrous scaffolds similar to the architecture of natural bone were prepared via wet spinning. CCK‐8 assay revealed that Sr‐containing scaffolds possessed better bioactivity and supported favorable cell growth effectively. The aligned PLGA/SrCSH fibers exerted a contact effect on cell attachment, inducing regular cell alignment and influencing a series of cell behaviors. Releasing of high concentration Sr from a‐PLGA/SrCSH scaffolds could induce high expression levels of BMP‐2, increase ALP activity and upregulate RUNX‐2 expression, and further promote the expressions of COL‐I and OCN and the maximum mineralization. This study demonstrated that Sr and ordered structure in a‐PLGA/SrCSH fibrous scaffolds could synergistically enhance the osteogenic differentiation of umbilical cord mesenchymal stem cells (UCMSCs) by regulating cell arrangement and expressions of osteogenic genes.

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In situ polydopamine functionalized poly-L-lactic acid nanofibers with near-infrared-triggered antibacterial and reactive oxygen species scavenging capability

Cited by 20 publications

References 57 publications

Nanotechnologies for control of pathogenic microbial biofilms

Nanotechnologies for control of pathogenic microbial biofilms

Antibacterial Activity of Antibiotic-Releasing Polydopamine-Coated Nephrite Composites for Application in Drug-Eluting Contact Lens

Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells

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