In Situ One‐Pot Synthesis of MOF–Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy

Wang, Dongdong; Wu, Huihui; Zhang, Jiajia; Xu, Pengping; Wang, Changlai; Shi, Ruohong; Wang, Haibao; Wang, Hui; Guo, Zhen; Chen, Qianwang

doi:10.1002/advs.201800287

Cited by 118 publications

(59 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure a illustrates the stepwise synthesis and surface modification of MCOPP NE for the O 2 generation and enhanced 1 O 2 production. First, the Mn 3 [Co(CN) 6 ] 2 MOFs were fabricated using a co‐precipitation method . Transmission electron microscopy (TEM) images reveal that the as‐prepared MOF nanoparticles had a cubic morphology and were uniformly dispersed with an average diameter of 75 nm (Figure S1, Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT), a wellknown clinical modality that involves photosensitizer, molecular oxygen (O 2 ), and excitation light to generate cytotoxic reactive oxygen species such as singlet oxygen ( 1 O 2 ), has been proven to be a selective method for treating a wide spectrum of localized and superficial cancers or other diseases. [1][2][3][4][5][6][7][8][9] In addition to destroying cancer cells through direct photodamage, PDT can also induce vascular damage in the tumor, and activate the response of immune system. [10][11][12][13] Possessing spatial and temporal control over the localization of the light irradiation, the O 2 -involved PDT can remarkably improve the selectivity and reduce the side effects when compared to other conventional modalities such as chemotherapy, surgery, and radiotherapy. [14][15][16] On the other hand, tumor hypoxia compromises therapeutic effect of PDT, as O 2 is an indispensable element during the process. Uncontrollable growth of tumor cells as well as dysregulated formation of tumor blood vessels inevitably result in the cancer hypoxia. [17,18] In addition, microvascular collapse caused by PDT would further compromise the O 2 supply and aggravate the hypoxia condition, thus preventing effective PDT of cancer. Consequently, a vicious circle occurs, as PDT not only consumes localized O 2 , but also cuts off the O 2 supply. [19][20][21] To date, three main strategies have been employed to overcome the pre-existing hypoxia and improve the therapeutic effect of PDT. The most popular approach relies on the integration of PDT with other therapeutic modalities for a synergistic therapy. [17,22,23] However, such complex structures are often costly, which limit their scalable production and reproducibility. Another strategy is the utilization of intelligent nanomaterials that can act as O 2 carriers for direct transportation of mole cular oxygen to tumor sites. For example, Hu and coworkers reported photosensitizer-loaded perfluorocarbon nanodroplets as an O 2 self-enriched PDT nanoplatform. [24] The last approach is to construct smart nanoplatforms for in situ generation of O 2 within solid tumors based on the characteristics Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen ( 1 O 2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for in situ generation of endogenous O 2 to enhancethe PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O 2 generation through the...

show abstract

Section: Methodsmentioning

confidence: 99%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…It was also reported that noble metal nanoparticles such as Ru, Pt and Au nanoparticles have catalase-like nanozyme activities [40][41][42] . In addition, the polarizable π-electron cloud of [Co(CN) 6 ] may have a certain affinity to cargos with conjugated structures 43 . Thus, during organic linker-metal coordination process, various bioactive molecules could be conveniently encapsulated, indicating that the metal-organic coordination might be an efficient approach for incorporating single-atom catalytic active sites and therapeutic agents in the assembled materials.…”

mentioning

confidence: 99%

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

et al. 2020

Self Cite

View full text Add to dashboard Cite

Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O 2 molecules to produce highly cytotoxic singlet oxygen (1 O 2) species. Herein, we present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn 3 [Co(CN) 6 ] 2 with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O 2 generation through the reaction between endogenous H 2 O 2 and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.

show abstract

“…Moreover, a zinc (Zn)-based MOF could be concocted in a modified dimensional structure for the ramification of better adsorption-reduction capacity. It is noteworthy that the integration of improved ligand-to-metal synergy achieves better photothermal resilience; this aspect not only increases the recyclability of ordinary MOFs' photocatalysts but also critical determinant characteristics for PS design [190]. To elucidate this aspect, in 2018, Ye et al studied ultrathin two-dimensional Zn-MOF [Zn porphyrin], based on TCPP ligand, nanosheet with BET surface area of 445 m 2 •g −1 and CO 2 adsorption potential of 103.8 cm 3 •g −1 .…”

Section: Zn-based Mofsmentioning

confidence: 99%

Recent Innovation of Metal-Organic Frameworks for Carbon Dioxide Photocatalytic Reduction

2019

View full text Add to dashboard Cite

The accumulation of carbon dioxide (CO2) pollutants in the atmosphere begets global warming, forcing us to face tangible catastrophes worldwide. Environmental affability, affordability, and efficient CO2 metamorphotic capacity are critical factors for photocatalysts; metal-organic frameworks (MOFs) are one of the best candidates. MOFs, as hybrid organic ligand and inorganic nodal metal with tailorable morphological texture and adaptable electronic structure, are contemporary artificial photocatalysts. The semiconducting nature and porous topology of MOFs, respectively, assists with photogenerated multi-exciton injection and adsorption of substrate proximate to void cavities, thereby converting CO2. The vitality of the employment of MOFs in CO2 photolytic reaction has emerged from the fact that they are not only an inherently eco-friendly weapon for pollutant extermination, but also a potential tool for alleviating foreseeable fuel crises. The excellent synergistic interaction between the central metal and organic linker allows decisive implementation for the design, integration, and application of the catalytic bundle. In this review, we presented recent MOF headway focusing on reports of the last three years, exhaustively categorized based on central metal-type, and novel discussion, from material preparation to photocatalytic, simulated performance recordings of respective as-synthesized materials. The selective CO2 reduction capacities into syngas or formate of standalone or composite MOFs with definite photocatalytic reaction conditions was considered and compared.

show abstract

In Situ One‐Pot Synthesis of MOF–Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy

Cited by 118 publications

References 56 publications

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Recent Innovation of Metal-Organic Frameworks for Carbon Dioxide Photocatalytic Reduction

Contact Info

Product

Resources

About