In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility

Abstract

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.

Thermoplastic elastomers based on poly(l‐Lysine)‐Poly(ε‐Caprolactone) multi‐block copolymers

“…PCL ( M n,NMR = 1900 g/mol, DP n = 17) and a tri‐block copolymer PCL 9 ‐ b ‐PEG 14 ‐ b ‐PCL 9 (PCEC) ( M n,NMR = 2560 g/mol) precursors containing α,ω‐dihydroxyl end groups were prepared by ROP of CL initiated by 1,4‐butanediol and PEG ( M n = 600 g/mol), respectively, in the presence of Sn(Oct) 2 as catalyst which was well‐documented for a living ROP of CL . PEG introduces a hydrophilic segment in the polymer, which has good biocompatibility …”

“…23,24 PEG introduces a hydrophilic segment in the polymer, which has good biocompatibility. 25,26 The multi-block copolymers were synthesized by chain extension reactions of the two precursors as illustrated in Scheme 2. L-Lysine diisocyanate (LDI) was a diisocyanate derivative of L-lysine ethyl ester.…”

Polyglutamic acid-based crosslinked doxorubicin nanogels as an anti-metastatic treatment for triple negative breast cancer

“…For the development of PGA NGs, we synthesized a series of alkyne-and azide-derivatized PGAs as a first step (as previously described by us in Barz et al 25 ) using a PGA with a molecular weight (Mw) of 10,500 Da and polydispersity (PDI) of 1.1. 28 We employed propargylamine and oligoethylene glycol azide residues for alkyne and azide functionalization, respectively, to yield compounds with orthogonal functionalities (see Scheme 1, Scheme S1, and Table S1 in the ESI).…”

Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA

“…The functionalization of the peripheral azides in GATG with unprotected ligands (carbohydrates, anionic and cationic moieties, peptides, imaging agents) by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, "click" chemistry), [43][44][45] has been exploited in the preparation of a variety of functional dendritic nanostructures for various biomedical applications. 42,46 Version: Postprint (identical content as published paper) This is a self-archived document from i3S -Instituto de Investigação e Inovação em Saúde in the University of Porto Open Repository For Open Access to more of our publications, please visit http://repositorio-aberto.up.pt/…”